Neural Basis of Sensory and Motor Learning: Functional Connections

NCT05124301 | Completed Results

• 2 other identifiers: 13138R01NS112367-01A1
• Study Type: interventional
• Target: 76
• Locations: 1 country
• Sites: 1

Brief Summary

The purpose of this study is to understand how the sensory and motor areas of the brain work together to keep a person's hand movements accurate (sensorimotor learning). The investigators hope this information may be useful one day to improve rehabilitation techniques in patients with brain lesions.

Conditions

Basic Science

Outcome Measures

Primary Outcomes (2)

• Resting-state PMv-M1 Functional Connectivity (Fisher Z-transformed Correlation)

  Brain activity was measured during a 12-minute resting-state functional magnetic resonance imaging (fMRI) scan. Resting-state functional connectivity between the ventral premotor cortex (PMv) and primary motor cortex (M1) was quantified as the Pearson correlation coefficient between the mean blood-oxygen-level-dependent (BOLD) time series extracted from anatomically defined PMv and M1 regions of interest. Correlation coefficients were Fisher z-transformed to improve normality. For each participant, connectivity values were averaged across all scans acquired during the main session. The outcome measure is the mean Fisher z-transformed correlation value (unitless). Numbers range from -1 (opposite activity in the two regions) to 1 (similar activity in the two regions), with 0 implying no relationship between the two regions.

  3 scans during the main session (2 hours)

• Weighting of Vision vs. Proprioception

  Measured by comparing where subjects point on the touchscreen when they are estimating visual vs. proprioceptive targets. A person who relies only on vision would have a weighting value of 100%. A person who relies only on proprioception would have a weighting of 0%. A value of 50% would imply equal reliance on vision and proprioception.

  Measured during the main session (2 hours)

Study Arms (1)

Perceptual learning

EXPERIMENTAL

Reaching task in which visual information about target finger position is offset to induce a change in perception of the finger.

Behavioral: Perceptual learning

Interventions

Perceptual learning BEHAVIORAL

Reaching task with visual feedback offset from target finger position.

Perceptual learning

Eligibility Criteria

• Age: 18 Years - 45 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• Ages of 18-45 years old
• Right-handed.
• Free of Covid symptoms in week preceding testing.

You may not qualify if:

• metallic, mechanical, or magnetic implants;
• are claustrophobic, or are unable to remain still for long periods of time;
• use an intra-uterine device (IUD) whos MR compatibility has not been established.
• Women who are pregnant or think they might be pregnant will also be excluded, as effects of fMRI on the unborn are not known.
• People who have a BMI over 30 will be excluded as it may be uncomfortable or impossible to lay in the MRI scanner and reach the button box.
• Potential subjects will be excluded if they have any neurological disorders, or orthopedic or pain conditions in the upper limbs.
• Investigators will also exclude subjects who do not have normal vision, or corrected-to-normal vision with contacts, or the imaging center does not have a pair of MRI compatible glasses that fits their prescription.
• investigators will invite subjects to reschedule if they have any of the common Covid symptoms within the last week and if they haven't been fully vaccinated or obtained a negative Covid test within the past 4 days. If they don't believe they can meet these criteria on another date, they will be excluded.
• After giving their consent, participants may be excluded during the study if they are unable to perform the tasks or follow instructions.

Sponsors & Collaborators

• Indiana University: lead
• National Institute of Neurological Disorders and Stroke (NINDS): collaborator

Study Sites (1)

Indiana University Bloomington

Bloomington, Indiana, 47405, United States

Location

Results Point of Contact

• Title: Dr. Hannah Block
• Organization: Indiana University Bloomington

hjblock@iu.edu

8128555390

Study Officials

• Hannah Block

  Indiana University, Bloomington

  PRINCIPAL INVESTIGATOR

Publication Agreements

• PI is Sponsor Employee: No
• Restrictive Agreement: No

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NA
• Masking: NONE
• Purpose: BASIC SCIENCE
• Intervention Model: SINGLE GROUP
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Associate Professor

Study Record Dates

• First Submitted: November 4, 2021
• First Posted: November 17, 2021
• Study Start: April 13, 2022
• Primary Completion: June 13, 2024
• Study Completion: June 13, 2024
• Last Updated: January 28, 2026
• Results First Posted: January 28, 2026

Record last verified: 2025-12

Data Sharing

• IPD Sharing: Will share
• Shared Documents: ANALYTIC CODE
• Time Frame: The data will become available when group results are published in peer-reviewed journals
• Access Criteria: Data will be available on www.osf.io for anyone who wishes to download it. The relevant osf registry will be cited in the peer-reviewed publication so that interested readers can find it.

Locations

US (1)