A Cohort Study of Environmental Endocrine Disrupting Chemicals and Female Reproductive Health
PKU-ERC
Adverse Effects and Mechanism of Environmental Endocrine Disrupting Chemicals on Female Reproductive health--the Peking University and Environment Reproductive Health Cohort
1 other identifier
observational
2,000
1 country
1
Brief Summary
Infertility is a disease that seriously affects the physical and mental health of women of childbearing age. The incidence of infertility has been increasing in recent years. Studies have shown that the occurrence of infertility may be related to environmental endocrine disrupting substances. This project was designed to establish a cohort study on environmental endocrine disrupting substances and in vitro fertilization (IVF) treatment, collect blood, urine, semen, follicular fluid, granulosa cells, chorionic decidua biological specimens, and then follow up on the pregnancy outcomes. The concentration of disrupting substances was detected and then found the associations between environmental endocrine disrupting substances and female reproductive health.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P75+ for all trials
Started Jan 2018
Longer than P75 for all trials
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
Study Start
First participant enrolled
January 1, 2018
CompletedFirst Submitted
Initial submission to the registry
April 19, 2022
CompletedFirst Posted
Study publicly available on registry
May 13, 2022
CompletedPrimary Completion
Last participant's last visit for primary outcome
December 1, 2022
CompletedStudy Completion
Last participant's last visit for all outcomes
December 1, 2022
CompletedMay 13, 2022
May 1, 2022
4.9 years
April 19, 2022
May 12, 2022
Conditions
Outcome Measures
Primary Outcomes (5)
Number of eggs retrieved
the number of eggs retrieved in the process of in vitro fertilization (IVF)
immediately after the eggs retrieved
the number of available embryos
the number of available embryos in the process of IVF
1 week after the eggs retrieved
the clinical pregnancy rate
the clinical pregnancy rate in the process of IVF
4 weeks after the embryos transfer
the miscarriage rate
the miscarriage rate in the process of IVF
7 months after embryos transfer
the live birth rate
the live birth rate in the process of IVF
40 weeks after embryos transfer
Interventions
there is no intervention in the study
Eligibility Criteria
All the couples intended to receive the treatment of IVF can be included in the study.
You may qualify if:
- Clinical diagnosis of infertile patients undergoing IVF treatment
You may not qualify if:
- Donor egg transplants excluded
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (1)
Peking University People's Hospital
Beijing, Beijing Municipality, China
Related Publications (1)
Wang H, Liang Y, Dong X, Fu M, Wang Y, Wang Y, Han H, Wang M, Zuo Y, Zhang S, Shen H, Han F, Gao F. Association between snoring and in vitro fertilization outcomes among infertile women. Sleep Med. 2025 Apr;128:74-81. doi: 10.1016/j.sleep.2025.01.013. Epub 2025 Jan 21.
PMID: 39892082DERIVED
Biospecimen
the urine, blood, follicular fluid，semen，villous tissue and placenta
Central Study Contacts
Study Design
- Study Type
- observational
- Observational Model
- COHORT
- Time Perspective
- PROSPECTIVE
- Sponsor Type
- OTHER
- Responsible Party
- PRINCIPAL INVESTIGATOR
- PI Title
- Director of Reproductive Medicine Center
Study Record Dates
First Submitted
April 19, 2022
First Posted
May 13, 2022
Study Start
January 1, 2018
Primary Completion
December 1, 2022
Study Completion
December 1, 2022
Last Updated
May 13, 2022
Record last verified: 2022-05
Data Sharing
- IPD Sharing
- Will not share