The Incidence of Postoperative Pulmonary Complications in Patients With a Positive and Negative AIR-Test During General Anesthesia

NCT05345743 | Completed

• 1 other identifier: W22_079
• Study Type: observational
• Target: 632
• Locations: 1 country
• Sites: 1

Brief Summary

The overall objective of this study is to describe the incidence of postoperative pulmonary complications in patients with a positive and negative AIR-test result. Second, the investigators wish to describe the incidence of a positive AIR-test and its association with the development of PPC. In addition, the investigators aim to describe whether mechanical ventilation strategy differs between patients with a positive and negative AIR-test.

Conditions

Surgery--Complications; Atelectasis; Anesthesia

Keywords

Anesthesia; AIR-test; Postoperative Pulmonary Complications

Outcome Measures

Primary Outcomes (1)

• The incidence of postoperative pulmonary complications

  Respiratory failure; Bronchospasm; Acute Respiratory Distress Syndrome (ARDS); Suspected pulmonary infection; Aspiration pneumonitis; Atelectasis; Pleural effusion; Pulmonary infiltrate; Cardiopulmonary effusion; Pneumothorax

  The first 5 postoperative days

Secondary Outcomes (11)

• AIR-test result

  Intraoperative period

• Tidal volume during general anesthesia for surgery

  Intraoperative period

• Positive End-Expiratory Pressure during general anesthesia for surgery

  Intraoperative period

• Peak Pressure during general anesthesia for surgery

  Intraoperative period

• Driving Pressure during general anesthesia for surgery

  Intraoperative period

Study Arms (2)

Positive AIR-test

Patients with a positive intraoperative AIR-test result

Procedure: Surgery

Negative AIR-test

Patients with a negative intraoperative AIR-test result

Procedure: Surgery

Interventions

Surgery PROCEDURE

All types of surgery requiring general anesthesia

Negative AIR-test; Positive AIR-test

Eligibility Criteria

• Age: 18 Years - 110 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

Adult patients undergoing surgery under general anesthesia in whom an AIR test is performed

You may qualify if:

• Patients undergoing surgery under general anesthesia in the Amsterdam University Medical Centers, location Meibergdreef with an Endotracheal Tube;
• Patients \> 18 years;
• Preoperative SpO2 of ≥97%;
• AIR-test performed after induction of anesthesia, in a hemodynamic and respiratory steady state.

You may not qualify if:

• Age \< 18 years;
• No consent/objection;
• Patient participated in another conflicting interventional study on mechanical ventilation during general anesthesia

Sponsors & Collaborators

• Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA): lead

Study Sites (1)

Amsterdam University Medical Centers

Amsterdam, North Holland, 1105 AZ, Netherlands

Location

Related Publications (1)

• Hol L, Vermeulen TD, de Kruijk RS, Tjikhoeri A, Koning GRM, Breel JS, van Meenen DMP, Hollmann MW, Schultz MJ. Associations of a positive intra-operative air-test with postoperative pulmonary complications in general surgery patients: A single-centre prospective observational study. Eur J Anaesthesiol. 2025 Oct 23. doi: 10.1097/EJA.0000000000002304. Online ahead of print.

  PMID: 41222052 DERIVED

MeSH Terms

Conditions

Pulmonary Atelectasis

Interventions

Surgical Procedures, Operative

Condition Hierarchy (Ancestors)

Lung Diseases; Respiratory Tract Diseases

Study Officials

• Markus W Hollmann, Professor

  Anesthesiology and Pain Medicine, AUMC location AMC

  PRINCIPAL INVESTIGATOR

• Marcus J Schultz, Professor

  Intensive Care, AUMC location AMC

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Prof. Dr.

Study Record Dates

• First Submitted: April 11, 2022
• First Posted: April 26, 2022
• Study Start: April 21, 2022
• Primary Completion: June 1, 2024
• Study Completion: June 1, 2024
• Last Updated: July 3, 2024

Record last verified: 2024-07

Locations

NL (1)