Relevance of Sensitization to Fenugreek in Children
1 other identifier
observational
50
1 country
1
Brief Summary
The prevalence of allergy to legumes is inscreasing, especially in children and for some of these legumes, little is known and there are not included in the list of priority allergen. The overall goal of this study is to improve knowledge about fenugreek allergy. The principal aim is to evaluate the prevalence of allergy to fenugreek confirmed by a positive oral food challenge in children sensitized to fenugreek. The secondary objectives are to describe the case of allergy to fenugreek (co-allergies, severity, age..), to evaluate diagnostic values of skin prick-tests and specific IgE and to compare the molecular profile of specific IgE to peanut between sensitization to fenugreek without allergy and sensitization with a confirmed allergy
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P25-P50 for all trials
Started Apr 2022
Shorter than P25 for all trials
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
Study Start
First participant enrolled
April 1, 2022
CompletedFirst Submitted
Initial submission to the registry
April 8, 2022
CompletedFirst Posted
Study publicly available on registry
April 22, 2022
CompletedPrimary Completion
Last participant's last visit for primary outcome
May 1, 2022
CompletedStudy Completion
Last participant's last visit for all outcomes
June 1, 2022
CompletedApril 22, 2022
April 1, 2022
1 month
April 8, 2022
April 15, 2022
Conditions
Keywords
Outcome Measures
Primary Outcomes (3)
Oral food challenge to fenugreek
Astier's score 0 to 4 (0=negative, 1 and 2=mild to moderate reaction, 3 and 4 = severe reaction)
2017-2022
skin prick-test to fenugreek
skin prick test positive if wheal size superior to 3mm
2017-2022
specific IgE to fenugreek
specific IgE positive if value superior to 0.35kU/L
2017-2022
Secondary Outcomes (2)
severity of allergy
2017-2022
molecular profile for peanut allergy
2017-2022
Interventions
diagnostic values of skin prick test and specific IgE for allergy confirmed by oral food challenge (routine, not an intervention)
Eligibility Criteria
children aged from 1 to 17 years old, sensitized to fenugreek with an evaluation of their tolerance to fenugreek by an oral food challenge
You may qualify if:
- Children for whom an oral food challenge to fenugreek has been performed between the 1st January 2017 and the 15th April 2022 and for whom skin prick test and/or specific IgE to fenugreek are avalaible
You may not qualify if:
- patient over 18 years old
- undeterminate oral food challenge
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (1)
Centre Hospitalo-Universitaire de Nancy
Vandœuvre-lès-Nancy, 54511, France
MeSH Terms
Conditions
Condition Hierarchy (Ancestors)
Study Officials
- PRINCIPAL INVESTIGATOR
Amandine Divaret-Chauveau, MD
centre hospitalo-universitaire de Nancy
Central Study Contacts
Study Design
- Study Type
- observational
- Observational Model
- COHORT
- Time Perspective
- RETROSPECTIVE
- Sponsor Type
- OTHER
- Responsible Party
- PRINCIPAL INVESTIGATOR
- PI Title
- Head of pediatric allergy department
Study Record Dates
First Submitted
April 8, 2022
First Posted
April 22, 2022
Study Start
April 1, 2022
Primary Completion
May 1, 2022
Study Completion
June 1, 2022
Last Updated
April 22, 2022
Record last verified: 2022-04
Data Sharing
- IPD Sharing
- Will not share