The Prevalence and Risk Factors of Irritable Bowel Syndrome Among Adults

NCT05340400 | Completed

• 1 other identifier: PRIBS Study
• Study Type: observational
• Target: 5,500
• Locations: 1 country
• Sites: 2

Brief Summary

This is a multicenter cross-sectional study on the prevalence of Irritable Bowel Syndrome and the risk factors associated with it. The Rome IV criteria is used for diagnosing IBS. A questionnaire-guided interview will be applied to all subjects.

Conditions

Irritable Bowel Syndrome; Colonic Diseases, Functional

Keywords

Rome IV criteria; Colonic Diseases; Digestive System Diseases; Irritable Bowel Syndrome

Outcome Measures

Primary Outcomes (1)

• The Prevalence of Irritable Bowel Syndrome

  Collaborators will make an interview questions using ROME IV to diagnose IBS among adults.

  30 days

Secondary Outcomes (5)

• Physical activity as risk factor for IBS

  30 days

• Perceived Stress Scale as risk factor for IBS

  30 days

• Fatigue as risk factor for IBS

  30 days

• Diet and weight questions as risk factor for IBS

  30 days

• Habits as risk factor for IBS

  30 days

Study Arms (2)

Patients diagnosed with IBS

Collaborators will use Rome IV criteria for diagnosing IBS, and then divide participants into those with and without the disease.

Other: ROME IV Criteria

Patients not diagnosed with IBS

Collaborators will use Rome IV criteria for diagnosing IBS, and then divide participants into those with and without the disease.

Other: ROME IV Criteria

Interventions

ROME IV Criteria OTHER

Collaborators will use Rome IV criteria for diagnosing IBS by the presence of the abdominal pain at least once a week in the last 3 months, in addition to at least two of the following: abdominal pain related to defecation, change in stool frequency, or shape.

Patients diagnosed with IBS; Patients not diagnosed with IBS

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Community sample.

You may qualify if:

• Volunteer to participate in the study

You may not qualify if:

• Poorly-controlled hyperthyroidism
• Poorly-controlled hypothyroidism
• Poorly-controlled hyperparathyroidism
• Liver disease
• Paralysis
• Parasitic diseases (worms ...)
• Celiac disease
• Inflammatory bowel disease (Crohn's disease or Ulcerative colitis)
• Lactose intolerance
• Cancer or tumor in the digestive tract

Sponsors & Collaborators

• University of Aleppo: lead

Study Sites (2)

Ahmad Yamen Arnaout

Aleppo, Syria

Location

University of Aleppo

Aleppo, Syria

Location

Related Publications (7)

• Mearin F, Lacy BE, Chang L, Chey WD, Lembo AJ, Simren M, Spiller R. Bowel Disorders. Gastroenterology. 2016 Feb 18:S0016-5085(16)00222-5. doi: 10.1053/j.gastro.2016.02.031. Online ahead of print.

  PMID: 27144627 BACKGROUND

• Longstreth GF, Thompson WG, Chey WD, Houghton LA, Mearin F, Spiller RC. Functional bowel disorders. Gastroenterology. 2006 Apr;130(5):1480-91. doi: 10.1053/j.gastro.2005.11.061.

  PMID: 16678561 BACKGROUND

• Drossman DA, Morris CB, Hu Y, Toner BB, Diamant N, Leserman J, Shetzline M, Dalton C, Bangdiwala SI. A prospective assessment of bowel habit in irritable bowel syndrome in women: defining an alternator. Gastroenterology. 2005 Mar;128(3):580-9. doi: 10.1053/j.gastro.2004.12.006.

  PMID: 15765393 BACKGROUND

• Palsson OS, Baggish JS, Turner MJ, Whitehead WE. IBS patients show frequent fluctuations between loose/watery and hard/lumpy stools: implications for treatment. Am J Gastroenterol. 2012 Feb;107(2):286-95. doi: 10.1038/ajg.2011.358. Epub 2011 Nov 8.

  PMID: 22068664 BACKGROUND

• Zamani M, Alizadeh-Tabari S, Zamani V. Systematic review with meta-analysis: the prevalence of anxiety and depression in patients with irritable bowel syndrome. Aliment Pharmacol Ther. 2019 Jul;50(2):132-143. doi: 10.1111/apt.15325. Epub 2019 Jun 3.

  PMID: 31157418 BACKGROUND

• Gralnek IM, Hays RD, Kilbourne A, Naliboff B, Mayer EA. The impact of irritable bowel syndrome on health-related quality of life. Gastroenterology. 2000 Sep;119(3):654-60. doi: 10.1053/gast.2000.16484.

  PMID: 10982758 BACKGROUND

• Arnaout AY, Nerabani Y, Douba Z, Kassem LH, Arnaout K, Shabouk MB, Zayat H, Mayo W, Bezo Y, Arnaout I, Yousef A, Zeina MB, Aljarad Z; PRIBS Study Team. The prevalence and risk factors of irritable bowel syndrome (PRIBS study) among adults in low- and middle-income countries: A multicenter cross-sectional study. Health Sci Rep. 2023 Oct 4;6(10):e1592. doi: 10.1002/hsr2.1592. eCollection 2023 Oct.

  PMID: 37808932 DERIVED

MeSH Terms

Conditions

Irritable Bowel Syndrome; Colonic Diseases, Functional; Colonic Diseases; Digestive System Diseases

Condition Hierarchy (Ancestors)

Intestinal Diseases; Gastrointestinal Diseases

Study Design

• Study Type: observational
• Observational Model: OTHER
• Time Perspective: CROSS SECTIONAL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Principal Investigator

Study Record Dates

• First Submitted: April 15, 2022
• First Posted: April 22, 2022
• Study Start: April 25, 2022
• Primary Completion: May 25, 2022
• Study Completion: June 10, 2022
• Last Updated: June 14, 2022

Record last verified: 2022-06

Data Sharing

• IPD Sharing: Will not share

Locations

SY (2)