Computer Cognitive Training for Post-acute COVID-19 Syndrome

NCT05338749 | Completed

• 1 other identifier: 20211020
• Study Type: interventional
• Target: 16
• Locations: 1 country
• Sites: 1

Brief Summary

This study will assess the acceptability, feasibility, and impact of game-based computer-delivered cognitive training on cognitive function in persons with cognitive symptoms that persist after recovery from acute coronavirus-19 (COVID) infection.

Conditions

Corona Virus Infection; Cognitive Dysfunction

Outcome Measures

Primary Outcomes (1)

• Technology Acceptance Model Questionnaire, Usefulness subscale

  User self-report of their perception that an application serves a function that may be helpful The score is the average of several items rated by the user from 0 to 6, so that the final score itself can range from 0 to 6. Higher scores indicate that the user found the intervention more useful. Higher scores are better.

  Three weeks

Secondary Outcomes (2)

• Cognitive Failures Questionnaire

  Three weeks

• Trail Making Test, Part B

  Three weeks

Study Arms (1)

Cognitive Training

EXPERIMENTAL

Participants in this condition will received game-based cognitive training.

Behavioral: Cognitive Training

Interventions

Cognitive Training BEHAVIORAL

Gamified cognitive training intervention to improve mental speed and attention.

Cognitive Training

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Persons with a history of COVID-19 infection confirmed through screening of symptom pattern or testing and report of mental symptoms (difficulties in attention, memory, or executive functions such as coordinating two activities at once) more than 30 days after resolution of the initial acute infection.

You may not qualify if:

• Cognitive or psychiatric conditions of a severity that precludes the person's ability to give informed consent for their participation or to attend and cooperate with assessment and training, as judged by the investigators.

Sponsors & Collaborators

• Nova Southeastern University: lead

Study Sites (1)

Center for Collaborative Research, Nova Southeastern University

Fort Lauderdale, Florida, 33314, United States

Location

Related Publications (1)

• Ownby RL, Kim J. Computer-Delivered Cognitive Training and Transcranial Direct Current Stimulation in Patients With HIV-Associated Neurocognitive Disorder: A Randomized Trial. Front Aging Neurosci. 2021 Nov 15;13:766311. doi: 10.3389/fnagi.2021.766311. eCollection 2021.

  PMID: 34867291 BACKGROUND

MeSH Terms

Conditions

Coronavirus Infections; Cognitive Dysfunction

Interventions

Cognitive Training

Condition Hierarchy (Ancestors)

Coronaviridae Infections; Nidovirales Infections; RNA Virus Infections; Virus Diseases; Infections; Cognition Disorders; Neurocognitive Disorders; Mental Disorders

Intervention Hierarchy (Ancestors)

Neurological Rehabilitation; Rehabilitation; Aftercare; Continuity of Patient Care; Patient Care; Therapeutics; Health Services; Health Care Facilities Workforce and Services

Study Officials

• Raymond L Ownby, MD, PhD

  Nova Southeastern University

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NA
• Masking: NONE
• Purpose: TREATMENT
• Intervention Model: SINGLE GROUP
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Model Details: Open label

Study Record Dates

• First Submitted: April 14, 2022
• First Posted: April 21, 2022
• Study Start: April 26, 2022
• Primary Completion: November 30, 2023
• Study Completion: November 30, 2023
• Last Updated: March 29, 2024

Record last verified: 2024-03

Data Sharing

• IPD Sharing: Will share
• Shared Documents: STUDY PROTOCOL, SAP
• Time Frame: After completion of study
• Access Criteria: On request from any qualified investigator.

Locations

US (1)