NCT05336799

Brief Summary

The high prevalence of myopia has become a global public health problem. The study amied to investigate the prevalence and progression of myopia associated with social environmental factors in Tianjin, a Chinese megacity in north China.

Trial Health

43
At Risk

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Trial has exceeded expected completion date
Enrollment
500,000

participants targeted

Target at P75+ for all trials

Timeline
Completed

Started Mar 2021

Longer than P75 for all trials

Geographic Reach
1 country

1 active site

Status
unknown

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Start

First participant enrolled

March 1, 2021

Completed
1.1 years until next milestone

First Submitted

Initial submission to the registry

April 8, 2022

Completed
12 days until next milestone

First Posted

Study publicly available on registry

April 20, 2022

Completed
8 months until next milestone

Primary Completion

Last participant's last visit for primary outcome

December 1, 2022

Completed
3.1 years until next milestone

Study Completion

Last participant's last visit for all outcomes

December 31, 2025

Completed
Last Updated

November 29, 2022

Status Verified

November 1, 2022

Enrollment Period

1.8 years

First QC Date

April 8, 2022

Last Update Submit

November 26, 2022

Conditions

Keywords

MyopiaSocioeconomics

Outcome Measures

Primary Outcomes (1)

  • Prevalence of myopia

    Myopia is defined as any eye's SER (sphere + 1/2 cylinder) of at least -0.5 diopters (D).

    up to 3years

Secondary Outcomes (2)

  • Changes in prevalence of myopia

    up to 3years

  • Changes of Spherical equivalent

    changes from baseline at 36months

Eligibility Criteria

Age6 Years - 18 Years
Sexall
Healthy VolunteersYes
Age GroupsChild (0-17), Adult (18-64)
Sampling MethodNon-Probability Sample
Study Population

All school-aged children and adolescents completed the vision screening in the included school.

You may qualify if:

  • aged 6 to 18 years
  • no ocular diseases and systemic diseases
  • consent to undergo an eye examination

You may not qualify if:

  • schoolchildren unwilling to participate

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

Tianjin Eye Hospital

Tianjin, Tianjin Municipality, China

RECRUITING

Related Publications (3)

  • Morgan IG, French AN, Ashby RS, Guo X, Ding X, He M, Rose KA. The epidemics of myopia: Aetiology and prevention. Prog Retin Eye Res. 2018 Jan;62:134-149. doi: 10.1016/j.preteyeres.2017.09.004. Epub 2017 Sep 23.

    PMID: 28951126BACKGROUND
  • Guo Y, Liu LJ, Xu L, Lv YY, Tang P, Feng Y, Meng M, Jonas JB. Outdoor activity and myopia among primary students in rural and urban regions of Beijing. Ophthalmology. 2013 Feb;120(2):277-83. doi: 10.1016/j.ophtha.2012.07.086. Epub 2012 Oct 23.

    PMID: 23098368BACKGROUND
  • Tenovuo J, Mielityinen H, Paunio K. The effect of dental plaque grown in the presence of xylitol or sucrose on bone resorption in vitro. Pharmacol Ther Dent. 1981;6(1-2):35-43.

    PMID: 6941318BACKGROUND

MeSH Terms

Conditions

MyopiaRefractive Errors

Condition Hierarchy (Ancestors)

Eye Diseases

Study Officials

  • yan wang

    Tianjin Eye Hospital

    STUDY CHAIR

Central Study Contacts

xiaoyan yang, director

CONTACT

yan wang, director

CONTACT

Study Design

Study Type
observational
Observational Model
COHORT
Time Perspective
PROSPECTIVE
Sponsor Type
OTHER
Responsible Party
SPONSOR

Study Record Dates

First Submitted

April 8, 2022

First Posted

April 20, 2022

Study Start

March 1, 2021

Primary Completion

December 1, 2022

Study Completion

December 31, 2025

Last Updated

November 29, 2022

Record last verified: 2022-11

Data Sharing

IPD Sharing
Will not share

Locations