NCT05327634

Brief Summary

The aim of this study is to highlight action guidelines to encourage acceptance of deprescribing in people over 75 years of age: training, therapeutic education, post-prescription follow-up, specific patient pathways, specific consultations or even the integration of an advanced practice nurse in this process.

Trial Health

87
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
120

participants targeted

Target at P50-P75 for all trials

Timeline
Completed

Started Apr 2022

Shorter than P25 for all trials

Geographic Reach
1 country

4 active sites

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Start

First participant enrolled

April 1, 2022

Completed
6 days until next milestone

First Submitted

Initial submission to the registry

April 7, 2022

Completed
7 days until next milestone

First Posted

Study publicly available on registry

April 14, 2022

Completed
10 months until next milestone

Primary Completion

Last participant's last visit for primary outcome

January 25, 2023

Completed
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

January 25, 2023

Completed
Last Updated

September 19, 2024

Status Verified

February 1, 2023

Enrollment Period

10 months

First QC Date

April 7, 2022

Last Update Submit

September 3, 2024

Conditions

Medication Abuse

Keywords

Elderly patientInappropriate drugsDeprescribingObstaclesFrench

Outcome Measures

Primary Outcomes (1)

  • Description of the obstacles to the withdrawal of medication in patients over 75 years of age in the geriatric sector

    The main evaluation criterion will be measured using the self-questionnaire: a revised form of the 5-point Likert-type "Revised Patients' Attitude Toward Deprescribing" (rPATD), validated in French. Discouragement will be assessed on the basis of the overall score of questions 1 to 20 of the self-questionnaire, with regard to questions 21 and 22.

    Baseline

Secondary Outcomes (5)

  • Assessment of the relationship between patient burden and acceptance (or refusal) of deprescribing.

    Baseline

  • Assessment of the relationship between the benefit of the treatment experienced by the patient and the acceptance (or refusal) of the deprescribing

    Baseline

  • Assessment of the relationship between concern about possible negative effects of discontinuing treatment and acceptance (or refusal) of deprescribing

    Baseline

  • Assessment of the relationship between the patient's good knowledge of their treatments and acceptance (or refusal) of the deprescribing.

    Baseline

  • Assessment of the relationship between certain families of treatments and acceptance (or refusal) of deprescribing

    Baseline

Study Arms (1)

Deprescribing

Prospective study on patients aged 75 and over, hospitalised in geriatric short stay or geriatric rehabilitation units

Other: self-questionnaire

Interventions

self-questionnaireOTHER

Prospective study on patients aged 75 and over, hospitalised in geriatric short stay or geriatric rehabilitation units

Deprescribing

Eligibility Criteria

Age75 Years+
Sexall
Healthy VolunteersNo
Age GroupsOlder Adult (65+)
Sampling MethodNon-Probability Sample
Study Population

Patients aged 75 and over hospitalised in geriatric short stay or geriatric rehabilitation units

You may qualify if:

  • Patients aged 75 years and over
  • Hospitalized in geriatric short-stay or geriatric rehabilitation units
  • Patients who did not object to participation in the study

You may not qualify if:

  • Patient refusal
  • Patients not able to understand and fill in the questionnaire: Cognitive disorders, Confusion, Unstable clinical state, Sensory disorders, not speaking French.
  • Patient under protective supervision (guardianship or curatorship)

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (4)

Short stay Geriatric department - Hospital Simone Veil

Beauvais, 60021, France

Location

SSR Geriatric department - Hospital Simone Veil

Beauvais, 60021, France

Location

Short stay Geriatric department - Hospital René Dubos

Pontoise, 95300, France

Location

SSR Geriatric department - Hospital René Dubos

Pontoise, 95300, France

Location

Related Publications (2)

  • Roux B, Sirois C, Niquille A, Spinewine A, Ouellet N, Petein C, Sibille FX, Csajka C, Reeve E, Villeneuve C, Laroche ML. Cross-cultural adaptation and psychometric validation of the revised Patients' Attitudes Towards Deprescribing (rPATD) questionnaire in French. Res Social Adm Pharm. 2021 Aug;17(8):1453-1462. doi: 10.1016/j.sapharm.2020.11.004. Epub 2020 Nov 10.

    PMID: 33317980BACKGROUND

  • Antoniazzi C, Cnockaert X, Michel P. Description of barriers to the deprescription of inappropriate drugs in French hospitalized geriatric services. Sci Rep. 2025 May 15;15(1):16837. doi: 10.1038/s41598-025-99752-9.

    PMID: 40374894DERIVED

MeSH Terms

Conditions

Substance-Related Disorders

Condition Hierarchy (Ancestors)

Chemically-Induced DisordersMental Disorders

Study Officials

  • Christophe Antoniazzi

    Hospital René Dubos

    PRINCIPAL INVESTIGATOR

Study Design

Study Type
observational
Observational Model
COHORT
Time Perspective
PROSPECTIVE
Sponsor Type
OTHER
Responsible Party
SPONSOR

Study Record Dates

First Submitted

April 7, 2022

First Posted

April 14, 2022

Study Start

April 1, 2022

Primary Completion

January 25, 2023

Study Completion

January 25, 2023

Last Updated

September 19, 2024

Record last verified: 2023-02

Data Sharing

IPD Sharing
Will not share

Locations

FR(4)