Diaphragm Thickness by Ultrasonography in Neurological Disorders

NCT05324176 | Completed

• 1 other identifier: MD.19.06.186.R1.R2
• Study Type: interventional
• Target: 60
• Locations: 1 country
• Sites: 1

Brief Summary

participants will be allocated into three groups, acute neuropathy (Guillain Barre Syndrome) group, neuromuscular junction disorder(myasthenia gravis ) group, and control group(people with neurological disorders not affecting the respiratory system.Ultrasonography is done on the diaphragm. The index test (ultrasound imaging of the diaphragm) is used. A high-resolution portable ultrasound machine is used, with a 7- to 13-MHz linear array transducer. Patients will be examined in the supine position. diaphragmatic thickness will is measured on both sides during a deep breath in inspiration and during expiration. objectives: primary outcome: to compare diaphragm thickness between the three examined groups. Secondary outcome: correlation between clinical scores and reference US values of diaphragm

Conditions

Guillain-Barre Syndrome; Myasthenia Gravis

Keywords

diaphragm thickness

Outcome Measures

Primary Outcomes (1)

• diaphragm thickness

  will be reported in (mm)

  within 24 hours from hospital admission

Secondary Outcomes (1)

• Hughes clinical score

  within 24 hours from hospital admission

Study Arms (3)

Gillian-Barre

ACTIVE COMPARATOR

Patients will be examined in the supine position. diaphragmatic thickness will is measured on both sides during a deep breath in inspiration and during expiration.

Radiation: diaphragmatic ultrasound

Myasthenia Gravis

ACTIVE COMPARATOR

Patients will be examined in the supine position. diaphragmatic thickness will is measured on both sides during a deep breath in inspiration and during expiration.

Radiation: diaphragmatic ultrasound

control

ACTIVE COMPARATOR

Patients hospitalized with neurological disorders without affection of the respiratory system.

Radiation: diaphragmatic ultrasound

Interventions

diaphragmatic ultrasound RADIATION

diaphragmatic thickness will be measured on both sides during a deep breath in inspiration and during expiration.

Gillian-Barre; Myasthenia Gravis; control

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• all adult patients admitted to the neurology department

You may not qualify if:

• cardiopulmonary diseases
• chest trauma
• diaphragmatic diseases
• Body Mass Index (BMI) \> 30

Sponsors & Collaborators

• Mansoura University: lead

Study Sites (1)

Mansoura University Hospitals

Al Mansurah, Not in US Or Canada, 35516, Egypt

Location

MeSH Terms

Conditions

Guillain-Barre Syndrome; Myasthenia Gravis

Condition Hierarchy (Ancestors)

Polyradiculoneuropathy; Autoimmune Diseases of the Nervous System; Nervous System Diseases; Demyelinating Diseases; Polyneuropathies; Peripheral Nervous System Diseases; Neuromuscular Diseases; Autoimmune Diseases; Immune System Diseases; Post-Infectious Disorders; Chronic Disease; Disease Attributes; Pathologic Processes; Pathological Conditions, Signs and Symptoms; Paraneoplastic Syndromes, Nervous System; Nervous System Neoplasms; Neoplasms by Site; Neoplasms; Paraneoplastic Syndromes; Neurodegenerative Diseases; Neuromuscular Junction Diseases

Study Officials

• Aya M Zhran

  Mansoura University Faculty of Medicine

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NON RANDOMIZED
• Masking: NONE
• Purpose: SCREENING
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Model Details: Patients will be examined in the supine position. diaphragmatic thickness will is measured on both sides during a deep breath in inspiration and during expiration in the 3 groups: (1) Gillian-Barre syndrome; (2) Myasthenia Gravis; (3) control

Study Record Dates

• First Submitted: April 4, 2022
• First Posted: April 12, 2022
• Study Start: April 13, 2022
• Primary Completion: May 9, 2022
• Study Completion: May 13, 2022
• Last Updated: May 16, 2022

Record last verified: 2022-05

Data Sharing

• IPD Sharing: Will share
• Time Frame: will be reported
• Access Criteria: will be reported

Locations

EG (1)