NCT05317962

Brief Summary

Investigation of the cardiac manifestations of COVID-19 in patients admitted to hospital

Trial Health

87
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
251

participants targeted

Target at P75+ for all trials

Timeline
Completed

Started May 2020

Geographic Reach
1 country

1 active site

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Start

First participant enrolled

May 12, 2020

Completed
4 months until next milestone

First Submitted

Initial submission to the registry

September 9, 2020

Completed
1.1 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

October 31, 2021

Completed
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

October 31, 2021

Completed
5 months until next milestone

First Posted

Study publicly available on registry

April 8, 2022

Completed
Last Updated

April 8, 2022

Status Verified

April 1, 2020

Enrollment Period

1.5 years

First QC Date

September 9, 2020

Last Update Submit

April 7, 2022

Conditions

Covid-19Cardiac Disease

Keywords

Echocardiography

Outcome Measures

Primary Outcomes (1)

  • Prevalence of cardiac abnormalities and relationship to admission to ICU

    6 weeks from start of admission

Secondary Outcomes (2)

  • Prevalence of cardiac abnormalities and relationship to need for mechanical ventilation

    6 weeks from start of admission

  • Prevalence of cardiac abnormalities and relationship to death or discharge

    6 weeks from start of admission

Study Arms (1)

COVID-19 positive patients admitted to hospital

Diagnostic Test: Transthoracic echocardiogram

Interventions

Transthoracic echocardiogramDIAGNOSTIC_TEST

Abbreviated transthoracic echocardiogram

COVID-19 positive patients admitted to hospital

Eligibility Criteria

Age18 Years+
Sexall
Healthy VolunteersNo
Age GroupsAdult (18-64), Older Adult (65+)
Sampling MethodNon-Probability Sample
Study Population

Patients referred to the cardiology department at Northwick Park Hospital to have a transthoracic echocardiogram who have also tested positive for COVID-19,

You may qualify if:

  • Age \> 18 years old
  • Positive swab or serology for COVID-19
  • Referred for echocardiographic evaluation for clinical reasons
  • Willing and able to give assent

You may not qualify if:

  • \. Known hypersensitivity to perflutren or known excipients in LUMINITY

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

London North West University Healthcare NHS Trust

Harrow, HA1 3UJ, United Kingdom

Location

MeSH Terms

Conditions

COVID-19Heart Diseases

Interventions

Echocardiography

Condition Hierarchy (Ancestors)

Pneumonia, ViralPneumoniaRespiratory Tract InfectionsInfectionsVirus DiseasesCoronavirus InfectionsCoronaviridae InfectionsNidovirales InfectionsRNA Virus InfectionsLung DiseasesRespiratory Tract DiseasesCardiovascular Diseases

Intervention Hierarchy (Ancestors)

Cardiac Imaging TechniquesDiagnostic ImagingDiagnostic Techniques and ProceduresDiagnosisUltrasonographyHeart Function TestsDiagnostic Techniques, Cardiovascular

Study Officials

  • Prof Roxy Senior, MD

    North West London University Healthcare NHS Trust

    PRINCIPAL INVESTIGATOR

Study Design

Study Type
observational
Observational Model
COHORT
Time Perspective
CROSS SECTIONAL
Sponsor Type
OTHER
Responsible Party
SPONSOR

Study Record Dates

First Submitted

September 9, 2020

First Posted

April 8, 2022

Study Start

May 12, 2020

Primary Completion

October 31, 2021

Study Completion

October 31, 2021

Last Updated

April 8, 2022

Record last verified: 2020-04

Data Sharing

IPD Sharing
Will not share

Locations

GB(1)