Perioperative Cardiac Arrest and Outcome

NCT05316779 | Completed

• 1 other identifier: 2021-02330
• Study Type: observational
• Target: 240
• Locations: 1 country
• Sites: 1

Brief Summary

With ethical approvement, the investigators want to assess the incidence, circumstances and outcomes of patients with perioperative cardiac arrests over a period of 8 years. Currently, there is little data and information about a cardiovascular arrests during anesthesia. Little is also known about the health-related quality of life afterwards. In the investigators research project, the investigators want to find out if there are, for example, specific factors that cause cardiovascular arrests and factors that can improve the chances of survival after a cardiovascular arrest. The investigators are also looking for possible factors and measurements that can minimize or even prevent future events during anesthesia.

Conditions

Heart Arrest; Anesthesia

Keywords

Cardiac arrest; Perioperative cardiac arrest; Neurological outcome; Quality of Life; In-hospital cardiac arrest

Outcome Measures

Primary Outcomes (1)

• Return of spontaneous circulation (ROSC)

  Number of patients with a Return of spontaneous circulation (ROSC) during resuscitation

  60 minutes

Secondary Outcomes (7)

• Sustained ROSC

  60 minutes

• Survival post-anaesthesia care unit or intensive care unit

  24 hours

• Survival to hospital discharge

  4 weeks

• SF-12 after hospital discharge

  1 month

• CPC after hospital discharge

  1 month

Eligibility Criteria

• Sex: all
• Healthy Volunteers: No
• Age Groups: Child (0-17), Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

The investigators will include all patients of all ages with a perioperative cardiac arrest at Bern University Hospital from 1st January 2015 until 31st December 2021.

You may qualify if:

• A perioperative cardiac arrest is defined as:
• ≥5 chest compressions (direct, mechanical or extracorporeal Cardiopulmonary Resuscitation (CPR))
• and/or defibrillation (unsynchronised direct current (DC) shock for ventricular fibrillation (VF) or pulseless ventricular tachycardia (pVT) either - external or internal defibrillation with manual or Automated External Defibrillation (AED), shocks by implanted cardioverter defibrillators (ICDs) for VF/pVT, precordial thump)
• In a patient having a procedure under the care of an anaesthesia team (nurse or anaesthesiologist) at the Bern University Hospital: General anaesthesia, regional anaesthesia/ analgesia, sedation, local anaesthesia or monitored anaesthesia care
• Regional block performed by anaesthesiologist outside of operating room
• Obstetric analgesia including remifentanil patient-controlled analgesia (PCA).

You may not qualify if:

• A perioperative cardiac arrest before 1st January 2015 or after 31st December 2021
• \<5 chest compressions (direct, mechanical or extracorporeal Cardiopulmonary Resuscitation (CPR))
• All in-hospital cardiac arrests, that occur without being under anaesthesia care
• Patients already admitted to a hospital with a cardiac arrest (out-of hospital cardiac arrests)

Sponsors & Collaborators

• Insel Gruppe AG, University Hospital Bern: lead

Study Sites (1)

University Hospital Bern

Bern, 3010, Switzerland

Location

MeSH Terms

Conditions

Heart Arrest

Condition Hierarchy (Ancestors)

Heart Diseases; Cardiovascular Diseases

Study Officials

• Robert Greif, MD, Prof

  University of Bern

  STUDY DIRECTOR

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: March 21, 2022
• First Posted: April 7, 2022
• Study Start: April 14, 2022
• Primary Completion: September 26, 2023
• Study Completion: October 25, 2023
• Last Updated: October 27, 2023

Record last verified: 2023-10

Data Sharing

• IPD Sharing: Will not share

Locations

CH (1)