Randomized Clinical Trial on the Effect of Intermittent Vibrational Force Application During Orthodontic Treatment With Aligners on RANKL and OPG Concentrations in Crevicular Fluid
Sponsor study identifier
interventional
45
1 country
1
Study Start
March 2016
Actual (reported)Primary Completion
March 1, 2022
Actual (reported)Study Completion
March 1, 2022
Actual (reported)This three-arm cross-over randomized clinical trial (allocation ratio of 1:1:1) will aim to explore whether the application of intermittent vibratory forces modify RANKL and OPG concentrations in patients undergoing orthodontic treatment with clear aligners. The specific objective will be to compare gingival crevicular fluid concentrations of RANKL and OPG among groups according to the application or not of Acceledent® treatment at different time points and frequencies of aligner changes.
Registry-reported information. Elapsed time and enrollment totals alone do not measure study progress or recruitment pace.
March 1, 2022
Actual (reported)Click on a node to explore related trials.
Some registry-reported names shown below are not yet linked in this graph.
Dates and qualifiers reported by the registry. Estimated dates do not confirm that a milestone has occurred.
March 2016
Actual (reported)March 1, 2022
Actual (reported)March 1, 2022
Actual (reported)March 21, 2022
Actual (reported)April 7, 2022
Actual (reported)RANKL concentration Baseline
Gingival crevicular fluid concentrations of RANKL at baseline
Baseline
RANKL concentration at 6 weeks
Gingival crevicular fluid concentrations of RANKL at 6 weeks
6 weeks
RANKL concentration at 12 weeks
Gingival crevicular fluid concentrations of RANKL at 12 weeks
12 weeks
RANKL concentration at 18 weeks
Gingival crevicular fluid concentrations of RANKL at 18 weeks
18 weeks
Plaque index
Baseline and 18 weeks
Gingival index
Baseline and 18 weeks
Bleeding on probing index
Baseline and 18 weeks
Orthodontic tooth movement achieved
Baseline and 18 weeks
Vibrational forces from onset of treatment, from weeks 0-6; then, no vibrational forces during the rest of the treatment
From weeks 0-6, no vibrational forces. Vibrational forces starting at 6 weeks after treatment onset and applied for 6 weeks until week 12
Faculty of Odontology, University Complutense Madrid
Madrid, 28040, Spain
Teti L, Perez-Idarraga A, Salcedo-Miranda M, Cacho A, Yeste-Ojeda F, Martin C. Randomised Clinical Trial on the Effect of Intermittent Vibrational Force Application During Orthodontic Treatment With Aligners on Root Resorption. Orthod Craniofac Res. 2025 Dec;28(6):1015-1026. doi: 10.1111/ocr.70028. Epub 2025 Sep 10.
Conchita Martin, Prof
Faculty of Odontology, University Complutense Madrid
45 participants (actual enrollment reported by the registry).
First Submitted
March 21, 2022
First Posted
April 7, 2022
Study Start
March 2016
Actual (reported)The Effect of Whole-body Vibration Training
Changes in Biomarkers Associated With Use of Electronic Cigarettes
OPG concentration Baseline
Gingival crevicular fluid concentrations of OPG at baseline
Baseline
OPG concentration at 6 weeks
Gingival crevicular fluid concentrations of OPG at 6 weeks
6 weeks
OPG concentration at 12 weeks
Gingival crevicular fluid concentrations of OPG at 12 weeks
12 weeks
OPG concentration at 18 weeks
Gingival crevicular fluid concentrations of OPG at 18 weeks
18 weeks
Control, no vibrational forces
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Primary Completion
March 1, 2022
Actual (reported)Study Completion
March 1, 2022
Actual (reported)Last Updated
April 7, 2022
Record last verified: 2022-03
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Source: ClinicalTrials.gov.
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