The Effects of Hydration on Gut Health and Thinking

NCT05315531 | Completed

• 1 other identifier: WatUP
• Study Type: interventional
• Target: 23
• Locations: 1 country
• Sites: 1

Brief Summary

The central hypothesis is that improving hydration through increased water consumption will change the relative abundance of mucolytic bacteria found in the stool. Therefore the specific aims are 1) to quantify intervention effects on fecal microbiota relative abundance and plasma lipopolysaccharide binding protein, 2) observe the effects of the intervention on bowel frequency and signs/symptoms of gastrointestinal stress, and 3) to investigate relations between executive function and hydration status.

Conditions

Dehydration; Cognitive Change; Gastrointestinal Microbiota

Outcome Measures

Primary Outcomes (2)

• Fecal microbiota relative abundance

  changes in the relative abundance of fecal microbiota

  3 weeks (baseline vs. follow-up)

• Plasma lipopolysaccharide (LPS)

  changes in circulating LPS

  3 weeks (baseline vs. follow-up)

Secondary Outcomes (6)

• Copeptin

  3 weeks (baseline vs. follow-up)

• 24hr Urine Osmolality

  3 weeks (baseline vs. follow-up)

• Attentional accuracy

  3 weeks (baseline vs. follow-up)

• Attentional Reaction Time

  3 weeks (baseline vs. follow-up)

• Attentional processing speed

  3 weeks (baseline vs. follow-up)

Study Arms (1)

Water Intake

EXPERIMENTAL

3-week intervention period during which articipants will be asked to increase their daily plain water consumption to at least 2.5 L/d of water for males and 2L/d for females.

Dietary Supplement: Water Intake

Interventions

Water Intake DIETARY_SUPPLEMENT

Participants will increase plain water consumption to at least 70% of the daily adequate intake for Americans depending on their sex.

Water Intake

Eligibility Criteria

• Age: 19 Years - 50 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• years of age
• kg/m2
• hour UOsm above 500 mOsm/kg
• No antibiotic use over the past 3 months
• Absence of metabolic diseases and use of diuretics
• Agree to maintain typical diet intake (e.g., dietary fiber) patterns during intervention
• Avoid consuming prebiotic and probiotic supplements during study participation
• Not pregnant
• Agree to follow the study protocol

You may not qualify if:

• \<19 or \>50 years of age
• \<18.5 or \>34.49 kg/m2
• hour UOsm \<500 mOsm/kg
• Antibiotic use over the past 3 months
• Metabolic diseases and use of diuretics
• Not agree to maintain typical diet intake (e.g., dietary fiber) patterns for the duration of the
• intervention
• Not agree with avoiding consuming prebiotic and probiotic supplements during study participation
• Pregnant
• Not agree to follow study protocol

Sponsors & Collaborators

• University of Illinois at Urbana-Champaign: lead
• Division of Nutritional Sciences, University of Illinois at Urbana-Champaign: collaborator

Study Sites (1)

University of Illinois at Urbana-Champaign

Urbana, Illinois, 61801, United States

Location

MeSH Terms

Conditions

Dehydration

Interventions

Drinking

Condition Hierarchy (Ancestors)

Water-Electrolyte Imbalance; Metabolic Diseases; Nutritional and Metabolic Diseases; Pathologic Processes; Pathological Conditions, Signs and Symptoms

Intervention Hierarchy (Ancestors)

Eating; Nutritional Physiological Phenomena; Diet, Food, and Nutrition; Physiological Phenomena; Digestive System Physiological Phenomena; Digestive System and Oral Physiological Phenomena

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NA
• Masking: NONE
• Purpose: PREVENTION
• Intervention Model: SINGLE GROUP
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Associate Professor

Model Details: Single arm hydration water intake intervention with a baseline urine concentration threshold for eligibility

Study Record Dates

• First Submitted: October 1, 2021
• First Posted: April 7, 2022
• Study Start: August 23, 2021
• Primary Completion: July 29, 2022
• Study Completion: July 29, 2022
• Last Updated: January 11, 2024

Record last verified: 2024-01

Data Sharing

• IPD Sharing: Will not share

Locations

US (1)