Water Intervention for Thinking in Kids (WITiKids ) Study
WITiKids
The Effects of Hydration on Brain, Cognition, Memory & Achievement in Childhood
1 other identifier
interventional
30
1 country
1
Brief Summary
The aim of this study is to determine the influence of changes in water intake on changes in cognitive function among preadolescent children. Further, the proposed work will determine the relationship between urinary markers of hydration process and cognitive function. We hypothesize that an increase in water intake will result in greater cognitive performance. In addition, improvements in hydration demonstrated by lower urine concentration will be correlated with greater cognitive performance.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at below P25 for not_applicable
Started Jun 2014
Longer than P75 for not_applicable
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
Study Start
First participant enrolled
June 1, 2014
CompletedPrimary Completion
Last participant's last visit for primary outcome
October 1, 2015
CompletedFirst Submitted
Initial submission to the registry
June 17, 2016
CompletedFirst Posted
Study publicly available on registry
June 28, 2016
CompletedStudy Completion
Last participant's last visit for all outcomes
June 1, 2018
CompletedJuly 31, 2018
July 1, 2018
1.3 years
June 17, 2016
July 28, 2018
Conditions
Keywords
Outcome Measures
Primary Outcomes (1)
Flanker Task Accuracy
2 Hours on the morning of Day 5
Secondary Outcomes (1)
Urine Osmolality
24 hours during final day of fluid intake modulation (Day 4)
Study Arms (2)
HIGH
EXPERIMENTALIncrease water intake to 2.5 liters per day for 4 days
LOW
EXPERIMENTALDecrease water intake to 0.5 liter per day for 4 days
Interventions
Eligibility Criteria
You may qualify if:
- Parental/guardian consent
- Normal or corrected-to-normal vision based on the minimal 20/20 standard in order to complete the cognitive task (below 20/20 vision).
You may not qualify if:
- Participants younger than 9 years and older than 10 years at the time of testing age.
- Prior diagnosis of cognitive or physical disability, including ADHD (severe asthma, epilepsy, chronic kidney disease, and dependence upon a wheelchair/walking aid).
- Use of anti-psychotic, anti-depressant, anti-anxiety medication, as well as those medications used for ADD/ADHD (use of any anti-psychotic, anti-depressant, anti-anxiety, and ADD/ADHD medications).
- Participants must have not yet reached, or be in the earliest stages, of puberty, as measured by a modified test of the Tanner Staging System
- IQ below 85
- Use of medications that alter urinary excretion and water metabolism
- Use of internal electronic device, such as a pacemaker
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (1)
Department of Kinesiology and Community Health
Urbana, Illinois, 61801, United States
Related Publications (1)
Khan NA, Westfall DR, Jones AR, Sinn MA, Bottin JH, Perrier ET, Hillman CH. A 4-d Water Intake Intervention Increases Hydration and Cognitive Flexibility among Preadolescent Children. J Nutr. 2019 Dec 1;149(12):2255-2264. doi: 10.1093/jn/nxz206.
PMID: 31504690DERIVED
MeSH Terms
Conditions
Interventions
Condition Hierarchy (Ancestors)
Intervention Hierarchy (Ancestors)
Study Design
- Study Type
- interventional
- Phase
- not applicable
- Allocation
- RANDOMIZED
- Masking
- NONE
- Purpose
- OTHER
- Intervention Model
- CROSSOVER
- Sponsor Type
- OTHER
- Responsible Party
- PRINCIPAL INVESTIGATOR
- PI Title
- Assistant Professor
Study Record Dates
First Submitted
June 17, 2016
First Posted
June 28, 2016
Study Start
June 1, 2014
Primary Completion
October 1, 2015
Study Completion
June 1, 2018
Last Updated
July 31, 2018
Record last verified: 2018-07