NCT05311436

Brief Summary

The objective of the research project is to establish an evidence-based sustainable nutrition service delivery platform for optimizing pregnancy weight gain, increasing dietary diversity of adolescent girls, and ensuring proper physical growth of under 2 children. Hypothesis

  1. 1.Pregnant Women: Intensive nutrition and WASH counseling, iron-folate, calcium supplementation during pregnancy, can improve gestational weight gain and improve hemoglobin status in pregnant women in a slum of Dhaka city
  2. 2.Adolescent girl: Iron and zinc supplementation and nutrition counseling on dietary diversity could improve nutritional status and dietary diversity score in adolescent girls of slums in Dhaka
  3. 3.Children \<2 years: Counselling on IYCF, growth monitoring, and promotion, ensuring six-monthly vitamin A supplementation, counseling on WASH, treatment of acute malnutrition, and daily 1 egg supplementation for 3 months for severely stunted children can improve the nutritional status of children
  4. 4.Counselling to improve Water, Sanitation and Hygiene (WASH) practice: WASH intervention can improve EED biomarkers

Trial Health

57
Monitor

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Trial has exceeded expected completion date
Enrollment
3,278

participants targeted

Target at P75+ for not_applicable

Timeline
Completed

Started Apr 2022

Typical duration for not_applicable

Geographic Reach
1 country

1 active site

Status
recruiting

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

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Study Timeline

Key milestones and dates

First Submitted

Initial submission to the registry

March 27, 2022

Completed
5 days until next milestone

Study Start

First participant enrolled

April 1, 2022

Completed
4 days until next milestone

First Posted

Study publicly available on registry

April 5, 2022

Completed
2.7 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

December 31, 2024

Completed
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

December 31, 2024

Completed
Last Updated

October 30, 2024

Status Verified

October 1, 2024

Enrollment Period

2.8 years

First QC Date

March 27, 2022

Last Update Submit

October 27, 2024

Conditions

Outcome Measures

Primary Outcomes (4)

  • Gestational weight gain

    Change in gestational weight gain and rate of weight gain in the pregnant woman

    From the 16th week of gestation to child birth

  • Dietary Diversity

    Change in Dietary Diversity of Adolescent Girl

    6 months

  • Improve linear growth

    Change in length for age z-score of children less than 2 years

    1 year

  • Improved maternal WASH practices

    Improvement in maternal WASH practics will be assessed through use of safe water, handwashing practice during critical times, use of hygienic/ improved toilet using a structured questionnaire

    6 months

Secondary Outcomes (2)

  • Hemoglobin level of adolescent girl

    6 months

  • IYCF indicators

    1 year

Other Outcomes (1)

  • Hemoglobin level of Pregnant woman

    16 week of pregnancy to child birth

Study Arms (2)

Experimental

EXPERIMENTAL

1. Pregnant women will receive monthly intensive dietary counseling, daily iron-folate, calcium supplementation, and at least four antenatal visits to local ANC service providers from enrollment before 16 weeks of gestation to delivery of the baby will be ensured. 2. Adolescent girls will receive twice-monthly nutrition education sessions to improve dietary diversity scores from enrolment to 6 months of enrollment. 3. Under 2y children will receive monthly growth monitoring and promotion, IYCF counseling 4. Under 2y children for WASH counseling group will receive twice-monthly nutrition education sessions for 6months to improve maternal WASH practices 5. Severely stunted children: Daily 1 egg for 3 consecutive months and 1 sachet of multiple micronutrient powder supplementation for 2 months.

Behavioral: Experimental - Intensive nutrition counselling for pregnant, adolescent and under2 children

Control

NO INTERVENTION

Participants will receive the standard of care in the area

Interventions

Pregnant women: Intensive dietary counseling using diet chart for locally available food, and to attend antenatal care services from local ANC providers, daily Iron, folic acid, and calcium supplementation. Adolescent girls: Group sessions in the nutrition centers with the adolescent girls will be conducted twice monthly for 6 months. Iron and folic acid (200 mg ferrous fumarate and 400 μg folic acid); once weekly for 3 months; zinc 10 mg daily for 1 month. Children \<2 years: Behavioral counseling sessions through monthly home visits on Infant and Young Child feeding, Growth monitoring and promotion, and water sanitation and hygiene, and food safety. Intensive WASH counselling: Intensive WASH counseling will be provided to separate group of child participants twice a month for 6 months. Severely stunted children: 1 egg supplementation for 3 months and 1 sachet of multiple micronutrient powder (1 RDA of vitamin A and C, iron-folic acid, and zinc) daily for 2 months.

Also known as: Iron, folic acid and calcium supplementation for pregnant women, Zinc and iron-folate supplementation to adolescent gilrs, Egg supplementation to severely stunted children daily for 3 months to
Experimental

Eligibility Criteria

Age1 Day - 39 Years
Sexall
Healthy VolunteersYes
Age GroupsChild (0-17), Adult (18-64)

You may qualify if:

  • Pregnant women:
  • Age 18-39 years
  • Before 16 weeks of gestation
  • BMI 15-24.99 kg/m2 measured on enrolment
  • Have the plan to stay in the study area till delivery
  • Willing to participate in the study
  • Not enrolled in any nutrition project/programme currently
  • Adolescent girls:
  • Aged 11-19 years
  • Willing to participate in the study
  • Not involved in any nutrition project/programme
  • Will stay in the study area for the next 2 years
  • Children:
  • Aged 0-24 months
  • Youngest child of the household
  • +2 more criteria

You may not qualify if:

  • Pregnant women:
  • Subject not willing to provide consent
  • Subject has the plan to migrate outside of the study area during the study period
  • Subject has a plan to go elsewhere ( village/ parents' house) for delivery
  • Any reported/diagnosed chronic diseases (such as hypertension, heart disease, chronic obstructive pulmonary disease, chronic kidney disease, chronic liver disease, pancreatic diseases, diabetes mellitus, thyroid dysfunction, immunological diseases, malignancy, or any other diseases which could impede compliance with the study protocol)
  • Extremely obese
  • Subject involved in any nutrition programme/ intervention currently
  • Adolescent girls:
  • Subject not willing to give assent/consent
  • Subject has the plan to migrate outside the study area during the study period
  • Subject involved in any nutrition programme/intervention currently
  • Children:
  • Caregiver/guardian not willing to provide consent
  • Have the plan to migrate outside of the study area during the study period
  • Child with any congenital anomaly
  • +1 more criteria

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

International Centre for Diarrhoeal Diseases Research, Bangladesh (icddr,b)

Dhaka, Dhaka Division, 1212, Bangladesh

RECRUITING

MeSH Terms

Conditions

Gestational Weight GainMalnutritionHealth Behavior

Interventions

GravidityIronFolic AcidZinc

Condition Hierarchy (Ancestors)

Weight GainBody Weight ChangesBody WeightSigns and SymptomsPathological Conditions, Signs and SymptomsNutrition DisordersNutritional and Metabolic DiseasesBehavior

Intervention Hierarchy (Ancestors)

Reproductive Physiological PhenomenaReproductive and Urinary Physiological PhenomenaPregnancyReproductionReproductive HistoryEpidemiologic FactorsPublic HealthEnvironment and Public HealthMetals, HeavyElementsInorganic ChemicalsTransition ElementsMetalsPterinsPteridinesHeterocyclic Compounds, 2-RingHeterocyclic Compounds, Fused-RingHeterocyclic Compounds

Study Officials

  • Mustafa Mahfuz, MBBS, MPH, PhD

    International Centre for Diarrhoeal Disease Research, Bangladesh

    PRINCIPAL INVESTIGATOR

Central Study Contacts

Mustafa Mahfuz, MBBS, MPH, PhD

CONTACT

Fahmida Farzana, MSc, MPH

CONTACT

Study Design

Study Type
interventional
Phase
not applicable
Allocation
NON RANDOMIZED
Masking
NONE
Purpose
PREVENTION
Intervention Model
PARALLEL
Sponsor Type
OTHER
Responsible Party
SPONSOR

Study Record Dates

First Submitted

March 27, 2022

First Posted

April 5, 2022

Study Start

April 1, 2022

Primary Completion

December 31, 2024

Study Completion

December 31, 2024

Last Updated

October 30, 2024

Record last verified: 2024-10

Locations