Efficacy Testing of Crassocephalum Rabens Extract Capsules

NCT05309161 | Completed

• 1 other identifier: 21-129-A
• Study Type: interventional
• Target: 40
• Locations: 1 country
• Sites: 1

Brief Summary

This study is to investigate the improveing effects of the Crassocephalum rebens extract on skin conditions in normal people.

Conditions

Aging

Outcome Measures

Primary Outcomes (18)

• Measurement of skin hydration

  Corneometer CM825 is used to measure the moisture of upper cheek (unit: Corneometer® unit)

  Week 0

• Measurement of skin hydration

  Corneometer CM825 is used to measure the moisture of upper cheek (unit: Corneometer® unit)

  Week 4

• Measurement of skin brightness

  Chroma Meter MM500 is employed to measure the brightness of upper cheek (unit: L\* value (L\* range: 0-100)).

  Week 0

• Measurement of skin brightness

  Chroma Meter MM500 is employed to measure the brightness of upper cheek (unit: L\* value (L\* range: 0-100)).

  Week 4

• Measurement of skin texture

  Visia® skin analysis system is used to measure the skin texture of full face (unit: number of fine lines)

  Week 0

• Measurement of skin texture

  Visia® skin analysis system is used to measure the skin texture of full face (unit: number of fine lines)

  Week 4

• Measurement of skin spots

  Visia® skin analysis system is used to measure the skin spots of full face (unit: number of spots)

  Week 0

• Measurement of skin spots

  Visia® skin analysis system is used to measure the skin spots of full face (unit: number of spots)

  Week 4

• Measurement of collagen content

  DermaLab® Series SkinLab Combo (Cortex) is employed to measure skin collagen content of upper cheek (unit: collagen density)

  Week 0

• Measurement of collagen content

  DermaLab® Series SkinLab Combo (Cortex) is employed to measure skin collagen content of upper cheek (unit: collagen density)

  Week 4

• Measurement of Crow's feet

  Visia® skin analysis system is used to measure the skin spots of full face (unit: number of Visia® skin analysis system is used to measure the skin spots of full face (unit: number of fine lines around eyes)

  Week 0

• Measurement of Crow's feet

  Visia® skin analysis system is used to measure the skin spots of full face (unit: number of Visia® skin analysis system is used to measure the skin spots of full face (unit: number of fine lines around eyes)

  Week 4

• Measurement of skin elasticity

  Cutometer® is used to measure the skin elasticity of upper cheek (unit: mm)

  Week 0

• Measurement of skin elasticity

  Cutometer® is used to measure the skin elasticity of upper cheek (unit: mm)

  Week 4

• Measurement of skin wrinkles

  Visia® skin analysis system is used to measure the skin wrinkles of full face (unit: number of wrinkles)

  Week 0

• Measurement of skin wrinkles

  Visia® skin analysis system is used to measure the skin wrinkles of full face (unit: number of wrinkles)

  Weeks 4

• Measurement of skin pores

  Visia® skin analysis system is used to measure the skin spots of full face (unit: number of pores)

  Week 0

• Measurement of skin pores

  Visia® skin analysis system is used to measure the skin spots of full face (unit: number of pores)

  Week 4

Study Arms (2)

A group (placebo)

PLACEBO COMPARATOR

Placebo

Dietary Supplement: Crassocephalum rabens extract

B group (experimental)

ACTIVE COMPARATOR

Crassocephalum rabens extract

Dietary Supplement: Crassocephalum rabens extract

Interventions

Crassocephalum rabens extract DIETARY_SUPPLEMENT

dosage: a capsule (180 mg)/day; duration: 1 month

A group (placebo); B group (experimental)

Eligibility Criteria

• Age: 20 Years+
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Age over 20 years
• Healthy people

You may not qualify if:

• Non-volunteer
• Pregnant and lactating women
• Hypersensitivity to the assigned product
• Diagnosed with skin diseases, liver diseases, kinedy disease, and other severe diseases
• Cosmetic, drug, or food allergies
• Concurrent aesthetic treatments (e.g., intense pulse light, medical peelings, or laser therapy)
• Aceepted aesthetic treatments one month ago before the study
• Chronic sun exposure (over 3 hours/day)
• The members of the research team

Sponsors & Collaborators

• Greenyn Biotechnology Co., Ltd.: lead
• Chia Nan University of Pharmacy ＆ Science: collaborator

Study Sites (1)

Chia Nan University of Pharmacy ＆ Science

Tainan, 71710, Taiwan

Location

Study Officials

• Chia-Hua Liang

  Department of Cosmetic Science, Chia Nan University of Pharmacy ＆ Science

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: DOUBLE
• Who Masked: PARTICIPANT, INVESTIGATOR
• Purpose: OTHER
• Intervention Model: PARALLEL
• Sponsor Type: INDUSTRY
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: March 16, 2022
• First Posted: April 4, 2022
• Study Start: March 14, 2022
• Primary Completion: June 30, 2022
• Study Completion: June 30, 2022
• Last Updated: August 3, 2022

Record last verified: 2022-03

Data Sharing

• IPD Sharing: Will not share

Locations

TW (1)