Pattern of Disease and Determinants of Clinical Outcomes Among ICU Patients

NCT05303831 | Completed DMC

• 1 other identifier: duirb/001/21-08
• Study Type: observational
• Target: 630
• Locations: 1 country
• Sites: 1

Brief Summary

The global mortality rate of patients on MV is very high which is varied with the income level of the country, duration of a mechanical ventilator, the pattern of disease, ICU staff profile, availability of medical supplies. All Studies conducted so far in Sub-Saharan Africa including Ethiopia among ICU patients primarily focused on the pattern of admission, the incidence of mortality, and its determinants. However, the body of evidence on the pattern of disease, the incidence of MV, and determinants of mortality among patients on MV is still uncertain and a topic of debate nationally as well as locally. Therefore, A multicenter prospective cohort study is planned to be carried out in Southern Ethiopia Teaching and referral hospital ICUs.

Conditions

Clinical Outcomes

Outcome Measures

Primary Outcomes (2)

• Incidence of mortality

  The incidence of mortality of patients in the ICU who are on Mechanical ventilator during 28-days follow up

  28-days

• time to death

  The time with which patients die during follow up

  28-days

Secondary Outcomes (3)

• time to wean from the MV

  28-days

• time to develop adverse events

  28-days

• Incidence of prolonged ventilation

  28-days

Interventions

Mechanical ventilator OTHER

patients on a mechanical ventilators in ICU will be followed for 28-days for clinical outcomes

Eligibility Criteria

• Age: 12 Years+
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Child (0-17), Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

All Adult patients who are on Mechanical ventilator in Dilla University referral hospital, Wolaita Sodo University Hospital, and Hawassa University specialized Hospital ICUs during the study period

You may not qualify if:

• Patients admitted to ICU on re-admission and patients with no attendants will be excluded.

Sponsors & Collaborators

• Dilla University: lead

Study Sites (1)

Dilla University

Addis Ababa, 914, Ethiopia

Location

Related Publications (1)

• Abate SM, Basu B, Jemal B, Ahmed S, Mantefardo B, Taye T. Pattern of disease and determinants of mortality among ICU patients on mechanical ventilator in Sub-Saharan Africa: a multilevel analysis. Crit Care. 2023 Jan 24;27(1):37. doi: 10.1186/s13054-023-04316-w.

  PMID: 36694238 DERIVED

MeSH Terms

Interventions

Ventilators, Mechanical

Intervention Hierarchy (Ancestors)

Equipment and Supplies

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Target Duration: 2 Years
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Assistant professor, thematic research leader

Study Record Dates

• First Submitted: March 21, 2022
• First Posted: March 31, 2022
• Study Start: April 4, 2022
• Primary Completion: August 29, 2022
• Study Completion: September 20, 2022
• Last Updated: December 6, 2022

Record last verified: 2022-12

Locations

ET (1)