Dynamic Hyperinflation In Mechanically Ventilated Chronic Obstructive Pulmonary Disease Patients

NCT03230617 | Unknown

• 1 other identifier: EDHMVCP
• Study Type: observational
• Target: 100
• Locations: 1 country
• Sites: 1

Brief Summary

Chronic obstructive pulmonary disease is a common respiratory condition that is characterized by inflammation of the large and small peripheral airways , the alveoli and adjacent capillary networks. Severe airflow obstruction that imposes a significant load on the respiratory system is a major manifestation of Chronic obstructive pulmonary disease. The reduced expiratory airflow also causes air trapping at the end of expiration , producing alveolar pressure that are higher than atmospheric pressure before the next breath. This condition is intrinsic positive end-expiratory pressure .

Conditions

Pulmonary Disease, Chronic Obstructive

Outcome Measures

Primary Outcomes (1)

• The duration of mechanical ventilation

  1 month

Study Arms (2)

Intrinsic positive end expiratory pressure > 5

chronic obstructive pulmonary disease patient with intrinsic positive end expiratory pressure more than5

Device: Mechanical ventilator

Auto positive end expiratory pressure < 5

chronic obstructive pulmonary disease patient with intrinsic positive end expiratory pressure less than5

Device: Mechanical ventilator

Interventions

Mechanical ventilator DEVICE

Mechanical ventilation, in the healthcare setting or home, helps patients breathe by assisting the inhalation of oxygen into the lungs and the exhalation of carbon dioxide. Depending on the patient's condition, mechanical ventilation can help support or completely control breathing.

Auto positive end expiratory pressure < 5; Intrinsic positive end expiratory pressure > 5

Eligibility Criteria

• Sex: all
• Healthy Volunteers: No
• Age Groups: Child (0-17), Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

All patient who diagnosed as chronic obstructive pulmonary disease admitted to the respiratory intensive care unit, chest department, Assiut university hospital, who are mechanically ventilated.

You may qualify if:

• patient with acute exacerbation of Chronic obstructive pulmonary disease and respiratory failure who are intubated and mechanically ventilated.

You may not qualify if:

• patient with neuromuscular diseases.
• patient with pulmonary vascular diseases e.g pulmonary embolism.

Sponsors & Collaborators

• Assiut University: lead

Study Sites (1)

Assiut University

Asyut, Egypt

Location

Related Publications (1)

• Reddy VG. Auto-PEEP: how to detect and how to prevent--a review. Middle East J Anaesthesiol. 2005 Jun;18(2):293-312.

  PMID: 16438005 BACKGROUND

MeSH Terms

Conditions

Pulmonary Disease, Chronic Obstructive

Interventions

Ventilators, Mechanical

Condition Hierarchy (Ancestors)

Lung Diseases, Obstructive; Lung Diseases; Respiratory Tract Diseases; Chronic Disease; Disease Attributes; Pathologic Processes; Pathological Conditions, Signs and Symptoms

Intervention Hierarchy (Ancestors)

Equipment and Supplies

Central Study Contacts

Suzan Salama, MSc

CONTACT

0101423616; Suzansalama61@yahoo.com

Aliae Abd Rabou, MD

CONTACT

01222302352; aliaehussein@Gmail.com

Study Design

• Study Type: observational
• Observational Model: OTHER
• Time Perspective: CROSS SECTIONAL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: principal investigator

Study Record Dates

• First Submitted: July 24, 2017
• First Posted: July 26, 2017
• Study Start: September 1, 2017
• Primary Completion: September 1, 2018
• Study Completion: December 31, 2018
• Last Updated: July 27, 2017

Record last verified: 2017-07

Locations

EG (1)