The Predictive and Diagnostic Value of Cystatin C and High Sensitive Troponin
1 other identifier
observational
172
1 country
1
Brief Summary
Our study is planning to evaluate patients with chronic kidney disease who come to the emergency department with chest pain. Estimated GFR (cisGFR) with cystatin and estimated GFR (creaGFR) with creatinine will be calculated. Symptoms, ECG and troponin values of patients will be evaluated for diagnosis of acute coronary syndrome
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P50-P75 for all trials
Started Mar 2022
Shorter than P25 for all trials
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
Study Start
First participant enrolled
March 7, 2022
CompletedFirst Submitted
Initial submission to the registry
March 9, 2022
CompletedFirst Posted
Study publicly available on registry
March 31, 2022
CompletedPrimary Completion
Last participant's last visit for primary outcome
January 7, 2023
CompletedStudy Completion
Last participant's last visit for all outcomes
February 1, 2023
CompletedMarch 31, 2022
March 1, 2022
10 months
March 9, 2022
March 29, 2022
Conditions
Outcome Measures
Primary Outcomes (2)
anticipated ACS
The role of cystatin C in diagnosis acute coronary syndrome when used with troponin in patients with chronic renal failure.
time passed until PCI (percutaneous coronary intervention) (pre-intervention) or admission to hospital
exclusion of acs
exclusion of ACS according to current guidelines
time passed during emergency department visit until discharge avarage of 3-6 hours
Study Arms (2)
patients with acute coronary syndrome
patients with chronic kidney disease having chest pain with ecg, symptom or cardiac troponin levels compatible with ACS
patients without acute coronary syndrome
patients with chronic kidney disease having chest pain with ecg, symptom or cardiac troponin levels NONcompatible with ACS
Interventions
conventional coronary angiography
Eligibility Criteria
patients with chronic kidney disease having chest pain and administered to emergency department for differential diagnosis of chest pain or equivalent of chest pain (dyspnea, diaphoresis, syncope, nausea, vomiting)
You may qualify if:
- Age over 18,
- chronic kidney diease having chest pain or equivalent of chest pain (dyspnea, diaphoresis, syncope, nausea, vomiting) -
You may not qualify if:
- STEMI,
- age less than 18,
- missing data,
- patients referred to or accepted from another medical facility
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (1)
Diskapi Research and Training Hospital
Ankara, 06110, Turkey (Türkiye)
Related Publications (1)
Hamzacebioglu E, Sonmez BM, Akcay G, Tulmac M, Kayisoglu S, Hatil SI, Gungor EB. Valency of cystatin C and creatinine on troponin values in chronic kidney disease patients with chest pain in emergency department. Am J Emerg Med. 2025 Mar;89:95-102. doi: 10.1016/j.ajem.2024.12.020. Epub 2024 Dec 13.
PMID: 39705855DERIVED
MeSH Terms
Conditions
Interventions
Condition Hierarchy (Ancestors)
Intervention Hierarchy (Ancestors)
Study Officials
- STUDY DIRECTOR
bedriye müge sönmez, assoc. prof.
research
Central Study Contacts
Study Design
- Study Type
- observational
- Observational Model
- OTHER
- Time Perspective
- PROSPECTIVE
- Sponsor Type
- OTHER
- Responsible Party
- PRINCIPAL INVESTIGATOR
- PI Title
- associate professor
Study Record Dates
First Submitted
March 9, 2022
First Posted
March 31, 2022
Study Start
March 7, 2022
Primary Completion
January 7, 2023
Study Completion
February 1, 2023
Last Updated
March 31, 2022
Record last verified: 2022-03