Dorsolateral Prefrontal Cortex Transcranial Direct Current and Muscle Fatigue Stimulation on Muscle Fatigue

NCT06389162 | Enrolling By Invitation

• 1 other identifier: UNLV-2024-115
• Study Type: interventional
• Target: 20
• Locations: 1 country
• Sites: 1

Brief Summary

The goal of this clinical trial is to learn if transcranial direct current stimulation (tDCS) of the dorsolateral prefrontal cortex (DLPFC) can impact muscle fatigue. The main questions it aims to answer are:

1. 1.Does tDCS of the left DLPFC increase the time that a fatiguing contraction can be maintained?
2. 2.Does tDCS of the left DLPFC decrease the rate of increase of muscle activity, force error, and standard deviation of force during a fatiguing contraction.

Conditions

Fatigue

Outcome Measures

Primary Outcomes (2)

• Time to Task Failure

  The time in seconds that a fatiguing contraction can be held

  5 months

• Fatigue Index

  The percent decline in force between the maximum voluntary contractions performed before and after the fatiguing contraction

  5 months

Secondary Outcomes (4)

• Average EMG activity

  5 months

• Force error

  5 months

• Standard deviation of force

  5 months

• 9 Hole Pegboard Test

  5 months

Study Arms (2)

tDCS

EXPERIMENTAL

Transcranial direct current stimulation applied to the left dorsolateral prefrontal cortex

Device: transcranial direct current stimulation

SHAM

SHAM COMPARATOR

SHAM transcranial direct current stimulation applied to the left dorsolateral prefrontal cortex

Device: transcranial direct current stimulation

Interventions

transcranial direct current stimulation DEVICE

Transcranial direct current stimulation is a type of non-invasive brain stimulation that involves passing a weak current between two electrodes placed on the scalp.

SHAM; tDCS

Eligibility Criteria

• Age: 18 Years - 50 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• Able to provide informed consent
• Free from any neurological or psychiatric condition
• Age between 18-50 years old
• Right-handed (as determined by the Edinburgh Handedness Inventory)

You may not qualify if:

• An uncontrolled medical condition (i.e. hypertension, diabetes, etc)
• Metal in the skull or the eye, such as a cardiac pacemaker, brain stimulator, shrapnel, surgical metal, clips in the brain, cochlear implants, and metal fragments in the eye.
• Hearing loss diagnosed by a doctor and requiring a hearing aid. Have had a brain tumor, a stroke, head trauma, epilepsy or a history of seizures, have a neurological disorder, a movement disorder, or have a head injury that involved being passed out for more than a few seconds.
• History of migraines
• implanted defibrillator or implanted neurostimulator
• Not done a similar fatigue study in the laboratory in the last 7 days.

Sponsors & Collaborators

• University of Nevada, Las Vegas: lead

Study Sites (1)

University of Nevada Las Vegas

Las Vegas, Nevada, 89154, United States

Location

MeSH Terms

Conditions

Fatigue

Interventions

Transcranial Direct Current Stimulation

Condition Hierarchy (Ancestors)

Signs and Symptoms; Pathological Conditions, Signs and Symptoms

Intervention Hierarchy (Ancestors)

Electric Stimulation Therapy; Therapeutics; Convulsive Therapy; Psychiatric Somatic Therapies; Behavioral Disciplines and Activities; Electroshock; Psychological Techniques

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: TRIPLE
• Who Masked: PARTICIPANT, INVESTIGATOR, OUTCOMES ASSESSOR
• Masking Details: Double-blind
• Purpose: TREATMENT
• Intervention Model: CROSSOVER
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Associate Professor

Study Record Dates

• First Submitted: April 24, 2024
• First Posted: April 29, 2024
• Study Start: April 4, 2024
• Primary Completion: August 31, 2024
• Study Completion: September 30, 2024
• Last Updated: April 29, 2024

Record last verified: 2024-04

Locations

US (1)