Effects of Acute Glycerol Ingestion on Performance, Metabolic and Biochemical Markers in International Athletes

NCT05295836 | Completed

• 1 other identifier: CE102102
• Study Type: interventional
• Target: 4
• Locations: 1 country
• Sites: 1

Brief Summary

This clinical study evaluates the acute effect of glycerol ingestion on performance (power output), weight, urine specific gravity, biochemical (antioxidants and lactate) and metabolic (indirect calorimetry) markers in international athletes in hot conditions. The investigators hypothesized that acute glycerol ingestion can prevent performance loss (power generated at submaximal intensity) in hot conditions. To justify this hypothesis, the investigators will measure the aforementioned markers, which could establish a cause-effect relationship between acute glycerol intake and decreased performance loss in hot conditions.

Conditions

Performance Enhancing Product Use; Change, Body Weight; Change, Body Temperature; Antioxidative Stress; Lactate Blood Increase; Thermal Sensation Disorders

Keywords

Power; Performance; Thermography; Metabolism; Endurance Sport; Ergogenic Aids; Oxygen uptake; Hydration; Hyperhydration

Outcome Measures

Primary Outcomes (4)

• Body weight

  Record body weight before and after the rectangular test

  Throughout study completion, an average of 3 weeks

• Urine specific gravity

  Record urine specific gravity by means a digital refractometer (Atago) before and after the rectangular test

  Throughout study completion, an average of 3 weeks

• Power output

  Record the power produced by means the stryd sensor (shoe) in the 1st, 5th, 10th and 15th series of the rectangular test

  Throughout study completion, an average of 3 weeks

• Body temperature

  Record body temperature by thermography of the head, trunk, and lower limbs, anterior and posterior in rest, after 5th and 10th series, and after completion of the rectangular test

  Throughout study completion, an average of 3 weeks

Secondary Outcomes (21)

• Lactate

  Throughout study completion, an average of 3 weeks

• Measurement of fast- and slow-acting antioxidants (Q1 and Q2) and total antioxidant capacity by a portable analyzer eBQC0101

  Throughout study completion, an average of 3 weeks

• Heart rate

  Throughout study completion, an average of 3 weeks

• VO2

  Throughout study completion, an average of 3 weeks

• CO2

  Throughout study completion, an average of 3 weeks

Study Arms (3)

CONTROL

NO INTERVENTION

In this phase of the study, the rectangular test will be performed in conditions of 16°C and 25-30% humidity, intaking 26 mL/kg/body weight of water one and a half hours before the test.

PLACEBO (PLA)

PLACEBO COMPARATOR

In this intervention, subjects will perform the rectangular test at 28°C and 25-30% humidity, ingesting 26 mL/kg/body weight of water and placebo one and a half hours before the test.

Other: PLACEBO

GLYCEROL (GLY)

EXPERIMENTAL

In this intervention, subjects will perform the rectangular test at 28°C and 25-30% humidity, ingesting 1.2 g + 26 mL/kg/body weight of water one and a half hours before the test.

Dietary Supplement: GLYCEROL

Interventions

PLACEBO OTHER

Athletes will perform the rectangular test at a temperature of 28°C and ingested 26 mL/kg body weight + placebo one and half hours before the test.

PLACEBO (PLA)

GLYCEROL DIETARY_SUPPLEMENT

Athletes will perform the rectangular test at a temperature of 28°C and ingested 26 mL/kg body weight + 1.2 g of glycerol one and half hours before the test.

GLYCEROL (GLY)

Eligibility Criteria

• Age: 25 Years - 35 Years
• Sex: male
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• Be an international athlete with the Spanish national athletics team.

You may not qualify if:

• Are smokers or regular alcohol drinkers,
• Have a metabolic, cardiorespiratory or digestive pathology or anomaly,
• Have an injury in the prior 6 months
• Are supplementing or medicating in the prior 2 weeks
• Have non-normal values in the blood analysis parameters.

Sponsors & Collaborators

• Francisco Javier Martínez Noguera: lead

Study Sites (1)

Research Center for High Performance Sport. Catholic University of Murcia

La Ñora, Murcia, 30830, Spain

Location

Related Links

• Research Center for High Performance Sport. Catholic University of Murcia

MeSH Terms

Conditions

Body Weight Changes; Body Temperature Changes; Hyperlactatemia; Somatosensory Disorders; Water Intoxication

Interventions

Glycerol

Condition Hierarchy (Ancestors)

Body Weight; Signs and Symptoms; Pathological Conditions, Signs and Symptoms; Metabolic Diseases; Nutritional and Metabolic Diseases; Sensation Disorders; Neurologic Manifestations; Nervous System Diseases; Water-Electrolyte Imbalance; Poisoning; Chemically-Induced Disorders

Intervention Hierarchy (Ancestors)

Triose Sugar Alcohols; Sugar Alcohols; Alcohols; Organic Chemicals; Carbohydrates

Study Officials

• Francisco Javier Martínez Noguera, PhD

  Research Center for High Performance Sport. Catholic University of Murcia

  STUDY CHAIR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: SINGLE
• Who Masked: PARTICIPANT
• Purpose: TREATMENT
• Intervention Model: CROSSOVER
• Sponsor Type: OTHER
• Responsible Party: SPONSOR INVESTIGATOR
• PI Title: Study coordinator (Investigator)

Model Details: A randomized crossover study will be conducted, in which 4 international walkers will perform 3 different conditions: CON) water intake of 26 mL/kg/weight at 16°C; PLA) 26 mL/kg/weight + placebo at 28°C and GLY) intake of 1.2 g glycerol + 26 mL/kg/weight at 28°C.

Study Record Dates

• First Submitted: February 24, 2022
• First Posted: March 25, 2022
• Study Start: February 10, 2022
• Primary Completion: February 25, 2022
• Study Completion: February 25, 2022
• Last Updated: March 25, 2022

Record last verified: 2022-03

Locations

ES (1)