Diuretics for Postpartum High Blood Pressure in Preeclampsia
DIUPRE
Effectiveness of Postpartum Furosemide on Recovery Blood Pressure in Puerperal Women with Severe Preeclampsia: a Randomized Clinical Trial
1 other identifier
interventional
120
1 country
1
Brief Summary
The purpose of this study is to determine if furosemide administered after the first 24 hours of delivery, in women with severe peeclampsia and eclampsia accelerates high blood pressure control and diminishes hospital stay.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P50-P75 for phase_4
Started Jun 2014
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
First Submitted
Initial submission to the registry
June 9, 2014
CompletedFirst Posted
Study publicly available on registry
June 13, 2014
CompletedStudy Start
First participant enrolled
June 20, 2014
CompletedPrimary Completion
Last participant's last visit for primary outcome
November 30, 2014
CompletedStudy Completion
Last participant's last visit for all outcomes
August 1, 2015
CompletedOctober 2, 2024
July 1, 2021
5 months
June 9, 2014
September 30, 2024
Conditions
Keywords
Outcome Measures
Primary Outcomes (1)
Mean blood pressure
from 24 hours after delivery to first 15 days of delivery
Secondary Outcomes (4)
postpartum hospital stay
from 24 hours after delivery to 15 days
Maintenance of antihypertensive therapy
From 24 hours up to 15 days of delivery
frequency of adverse effects
From 24 hours to 15 days after delivery
frequency of maternal complications
From 24 hours up to 15 days after delivery
Other Outcomes (2)
Frequency of very high blood pressure episode
from 24 hours after delivery until 15 days after delivery
Blood pressure control
From 24 hours after delivery to 15 days
Study Arms (2)
PLACEBO
PLACEBO COMPARATORPLACEBO: placebo, oral, every 24 hours for maximum 5 days
FUROSEMIDE
EXPERIMENTALFUROSEMIDE: 20mg furosemide, oral, every 24 hours for maximum 5 days
Interventions
Furosemide, 20mg pills, will be administered every 24 houras, for a maximum of five days
Placebo pills, identical to the intervention (furosemide pills), will be administered every 24 hour for a maximum of five days
Eligibility Criteria
You may qualify if:
- Preeclampsia
- Urine output \> 50ml/h
- End of postpartum magnesium sulphate
You may not qualify if:
- Cronic hypertension
- Bloor pressure \< 140mmHg and \< 90mmHg
- Diuretic use
- Renal impairment
- Diabetes, sickle cell disease ou rheumatologic disease
- Hemodinamic instability
- Potassium \< 3mEq/L
- Contraindications for fusoremide use
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (1)
IMIP
Recife, Pernambuco, 52020-070, Brazil
Related Publications (1)
Cursino T, Katz L, Coutinho I, Amorim M. Diuretics vs. placebo for postpartum blood pressure control in preeclampsia (DIUPRE): a randomized clinical trial. Reprod Health. 2015 Aug 5;12:66. doi: 10.1186/s12978-015-0057-0.
PMID: 26242730DERIVED
MeSH Terms
Conditions
Interventions
Condition Hierarchy (Ancestors)
Intervention Hierarchy (Ancestors)
Study Officials
- STUDY DIRECTOR
Leila Katz, MD PhD
IMIP
Study Design
- Study Type
- interventional
- Phase
- phase 4
- Allocation
- RANDOMIZED
- Masking
- QUADRUPLE
- Who Masked
- PARTICIPANT, CARE PROVIDER, INVESTIGATOR, OUTCOMES ASSESSOR
- Purpose
- TREATMENT
- Intervention Model
- PARALLEL
- Sponsor Type
- OTHER
- Responsible Party
- PRINCIPAL INVESTIGATOR
- PI Title
- PhD
Study Record Dates
First Submitted
June 9, 2014
First Posted
June 13, 2014
Study Start
June 20, 2014
Primary Completion
November 30, 2014
Study Completion
August 1, 2015
Last Updated
October 2, 2024
Record last verified: 2021-07