Cognitive Function and Brain Connectivity in CAS Patients:a Rs-fMRI Study
1 other identifier
observational
30
1 country
1
Brief Summary
This is a prospective study aimed to explore the changes of cognitive function after surgery for CAS and the correlation with brain connectivity, in order to look for the clinical biomarkers to predict the carotid stent implantation for patients which can effect the cognition
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at below P25 for all trials
Started Dec 2021
Shorter than P25 for all trials
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
Study Start
First participant enrolled
December 1, 2021
CompletedFirst Submitted
Initial submission to the registry
December 27, 2021
CompletedFirst Posted
Study publicly available on registry
March 23, 2022
CompletedPrimary Completion
Last participant's last visit for primary outcome
June 30, 2022
CompletedStudy Completion
Last participant's last visit for all outcomes
July 1, 2022
CompletedMarch 23, 2022
December 1, 2021
7 months
December 27, 2021
March 14, 2022
Conditions
Keywords
Outcome Measures
Primary Outcomes (4)
Montreal Cognitive Assessment, MOCA
use MOCA to assess the cognition before CAS
before CAS(within 1 week)
Mini-mental State Examination，MMSE
use MMSE to assess the cognition before CAS
before CAS(within 1 week)
Montreal Cognitive Assessment, MOCA
use MOCA to assess the cognition after CAS
3 months after CAS
Mini-mental State Examination，MMSE
use MMSE to assess the cognition after CAS
3 months after CAS
Secondary Outcomes (6)
Digit Symbol Test
before CAS(within 1 week)
Digit Symbol Test
3 months after CAS
Trail Making Test A/B
before CAS(within 1 week)
Trail Making Test A/B
3 months after CAS
digital span test
before CAS(within 1 week)
- +1 more secondary outcomes
Eligibility Criteria
consecutive enrolled patients with carotid artery stenosis who undergoing carotid artery stenting
You may qualify if:
- age between 55 years and 80 years
- unilateral internal carotid artery stenotic degree ≥ 70%
- right-hand-dominant
- free of stroke, TIA, dementia, and depression
- modified Rankin Scale: 0 or 1
- education ≥6 years
- obtained written informed consent.
You may not qualify if:
- contralateral internal carotid artery stenosis ≥ 50%
- posterior circulation diseases
- MMSE \< 26, which is a cut-off value for mild cognitive impairment
- severe systemic diseases and neuropsychiatric diseases (such as congestive heart failure and history of stroke)
- any contraindications for MRI scan (e.g., metal implants)
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (1)
the first affiliated hospital of Zhejiang university
Hangzhou, Zhejiang, 310016, China
Related Publications (1)
Ji R, Zhang S, Chen H, Deng C, Xu Z, Zhang J, Luo B. Impact of Endovascular Revascularization on Functional Connectivity and Cognition in Symptomatic Chronic Internal Carotid Artery Occlusion Patients: A Preliminary Exploratory Study. J Integr Neurosci. 2025 Apr 24;24(4):36330. doi: 10.31083/JIN36330.
PMID: 40302264DERIVED
MeSH Terms
Conditions
Condition Hierarchy (Ancestors)
Study Officials
- PRINCIPAL INVESTIGATOR
Benyan Luo, PhD
Zhejiang University
Central Study Contacts
Study Design
- Study Type
- observational
- Observational Model
- COHORT
- Time Perspective
- PROSPECTIVE
- Sponsor Type
- OTHER
- Responsible Party
- SPONSOR
Study Record Dates
First Submitted
December 27, 2021
First Posted
March 23, 2022
Study Start
December 1, 2021
Primary Completion
June 30, 2022
Study Completion
July 1, 2022
Last Updated
March 23, 2022
Record last verified: 2021-12
Data Sharing
- IPD Sharing
- Will not share