NCT05285670

Brief Summary

Use of a mobile health (mHealth) intervention to provide reproductive life counseling to women living with HIV may improve delivery of integrated reproductive health/HIV services and prevent adverse reproductive health outcomes. The proposed study will evaluate SMS platform and reproductive health counseling intervention in a cluster randomized controlled trial among women receiving routine HIV care, and plan for future implementation with qualitative and health economic analyses.

Trial Health

75
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
3,310

participants targeted

Target at P75+ for not_applicable hiv

Timeline
2mo left

Started Dec 2022

Typical duration for not_applicable hiv

Geographic Reach
1 country

10 active sites

Status
active not recruiting

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Progress96%
Dec 2022Jun 2026

First Submitted

Initial submission to the registry

February 18, 2022

Completed
27 days until next milestone

First Posted

Study publicly available on registry

March 17, 2022

Completed
9 months until next milestone

Study Start

First participant enrolled

December 1, 2022

Completed
3.6 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

June 30, 2026

Expected
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

June 30, 2026

Last Updated

February 5, 2026

Status Verified

February 1, 2026

Enrollment Period

3.6 years

First QC Date

February 18, 2022

Last Update Submit

February 3, 2026

Conditions

Keywords

mHealthHIVconceptioncounselingfertilityfamily planningSMSKenya

Outcome Measures

Primary Outcomes (1)

  • Contraceptive discontinuation

    Proportion not using contraception among women who initiated or continued contraception to prevent pregnancy

    2 years

Secondary Outcomes (2)

  • Uptake of dual methods of contraception

    2 years

  • Unmet need for contraception

    2 years

Other Outcomes (2)

  • Viral load suppression at conception

    Up to 2 years

  • Unintended pregnancy

    2 years

Study Arms (2)

Digital counseling plus interactive two-way SMS dialogue

EXPERIMENTAL

Participants will receive initial counseling on a tablet followed by automated SMS messages with prompts to reply. They will have the ability to both respond to and initiate SMS dialogue. Trained Study Nurses will monitor and respond to participant messages.

Behavioral: Digital counseling plus interactive two-way SMS dialogue

Control

NO INTERVENTION

Control receiving standard of care.

Interventions

We will utilize a digital counseling tool on a tablet to provide initial reproductive life planning counseling while waiting for an HIV care provider. We will then use Mobile WACh, a human-computer hybrid system that enables seamless two-way SMS communication and patient tracking, to provide consistent support to women following enrollment and for up to 2 years. Women will receive automated theoretically grounded SMS messages targeting the appropriate reproductive health needs and will have the capability to respond and spontaneously message a nurse based at the clinic. . Automated SMS will be delivered at times and in languages based on patient preferences, weekly the first 3 months, every other week in months 4-12, and monthly during the last year of the trial. If there is a change in the reproductive health needs, more frequent messaging will be re-initiated at the same frequency as enrollment.

Digital counseling plus interactive two-way SMS dialogue

Eligibility Criteria

Age14 Years - 45 Years
Sexfemale
Healthy VolunteersYes
Age GroupsChild (0-17), Adult (18-64)

You may qualify if:

  • HIV-infected
  • Receiving HIV care at study site
  • Reproductive age (18-45; 14-17 if emancipated minors)
  • Daily access to mobile phone (own phone or shared)
  • Plan to receive HIV care at enrollment facility for 2 years
  • Speak English, Kiswahili, or Luo
  • Literate or comfortable with someone reading study SMS

You may not qualify if:

  • Currently pregnant

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (10)

Bondo sub-County Hospital

Bondo, Kenya

Location

Kisumu District General Hospital

Kisumu, Kenya

Location

Lumumba sub-County Hospital

Kisumu, Kenya

Location

Dandora 2 Health Center

Nairobi, Kenya

Location

Kangemi Health Centre

Nairobi, Kenya

Location

Kenyatta National Hospital

Nairobi, Kenya

Location

Mathare North Health Center

Nairobi, Kenya

Location

Riruta Health Center

Nairobi, Kenya

Location

Rachuonyo District

Oyugis, Kenya

Location

Siaya District Hospital

Siaya, Kenya

Location

Related Publications (1)

  • Ngumbau N, Unger JA, Wandika B, Atieno C, Beima-Sofie K, Dettinger J, Nzove E, Harrington EK, Karume AK, Osborn L, Sharma M, Richardson BA, Seth A, Udren J, Zanial N, Kinuthia J, Drake AL. Mobile solutions to Empower reproductive life planning for women living with HIV in Kenya (MWACh EMPOWER): Protocol for a cluster randomized controlled trial. PLoS One. 2024 Apr 1;19(4):e0300642. doi: 10.1371/journal.pone.0300642. eCollection 2024.

    PMID: 38557692BACKGROUND

MeSH Terms

Conditions

Acquired Immunodeficiency SyndromeInfertility

Condition Hierarchy (Ancestors)

HIV InfectionsBlood-Borne InfectionsCommunicable DiseasesInfectionsSexually Transmitted Diseases, ViralSexually Transmitted DiseasesLentivirus InfectionsRetroviridae InfectionsRNA Virus InfectionsVirus DiseasesSlow Virus DiseasesGenital DiseasesUrogenital DiseasesImmunologic Deficiency SyndromesImmune System Diseases

Study Officials

  • Alison Drake, PHD

    University of Washington

    PRINCIPAL INVESTIGATOR

Study Design

Study Type
interventional
Phase
not applicable
Allocation
RANDOMIZED
Masking
NONE
Purpose
PREVENTION
Intervention Model
PARALLEL
Model Details: Participants will be randomized to 1) A digital counseling tool plus interactive two-way SMS dialogue or 2) Control (no SMS) at the clinic level, using 1:1 allocation at the clinic level.
Sponsor Type
OTHER
Responsible Party
PRINCIPAL INVESTIGATOR
PI Title
Associate Professor, SPH: Global Health

Study Record Dates

First Submitted

February 18, 2022

First Posted

March 17, 2022

Study Start

December 1, 2022

Primary Completion (Estimated)

June 30, 2026

Study Completion (Estimated)

June 30, 2026

Last Updated

February 5, 2026

Record last verified: 2026-02

Data Sharing

IPD Sharing
Will share

Data from Mobile WACh Empower will be available at end of the project by contacting the study team at the University of Washington. De-identified data and variables requested.

Shared Documents
STUDY PROTOCOL, SAP, ICF, ANALYTIC CODE
Time Frame
At the end of the study, available for 5 years

Locations