NCT05268588

Brief Summary

The goal of this study is to assess the effectiveness of a culturally-tailored mobile interactive education and support group intervention to supplement standard postpartum care activities in comparison to standard care alone on health-related behaviors and health outcomes in a randomized controlled trial among 2100 postpartum Indian women living in 3 geographically diverse Indian states to estimate the impact on maternal and neonatal health-related knowledge, health-related behaviors, and health outcomes. The investigators also seek to characterize mechanisms of impact including knowledge, social support, self-efficacy, and behavior change, and determine the cost-effectiveness.

Trial Health

77
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
2,100

participants targeted

Target at P75+ for not_applicable

Timeline
13mo left

Started Jan 2025

Typical duration for not_applicable

Geographic Reach
1 country

3 active sites

Status
recruiting

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Progress55%
Jan 2025May 2027

First Submitted

Initial submission to the registry

February 24, 2022

Completed
11 days until next milestone

First Posted

Study publicly available on registry

March 7, 2022

Completed
2.9 years until next milestone

Study Start

First participant enrolled

January 20, 2025

Completed
2.4 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

May 31, 2027

Expected
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

May 31, 2027

Last Updated

April 1, 2026

Status Verified

March 1, 2026

Enrollment Period

2.4 years

First QC Date

February 24, 2022

Last Update Submit

March 31, 2026

Conditions

Keywords

mHealthgroup care

Outcome Measures

Primary Outcomes (3)

  • Exclusive breastfeeding

    Proportion of participants reporting exclusive breastfeeding at 3 and 6 months

    6 months

  • Postpartum depression

    Proportion of participants reporting postpartum depression symptoms at 3 and 6 months

    6 months

  • Postpartum family planning adoption

    Proportion of participants not wanting to become pregnant immediately having started a modern contraceptive method within 6 months postpartum

    6 months

Secondary Outcomes (4)

  • Maternal and neonatal danger sign knowledge

    6 months

  • Maternal and neonatal health care use

    6 months

  • Neonatal preventive health care use

    6 months

  • Infant vaccination

    6 months

Study Arms (2)

Intervention Arm

EXPERIMENTAL

The mHealth education and social support intervention includes tailored weekly educational content via interactive voice recognition and an android application, a phone-based provider-moderated group discussion, a provider-moderated group text chat, and referral to care as needed. Individuals are enrolled into groups of 20, have two intervention sessions prenatally and then have weekly meetings through six months postpartum for a total of 26 sessions.

Behavioral: MESSSSAGE intervention

Control Arm

NO INTERVENTION

Standard postnatal care.

Interventions

group mHealth education and social support intervention

Intervention Arm

Eligibility Criteria

Age18 Years - 49 Years
Sexfemale
Healthy VolunteersNo
Age GroupsAdult (18-64)

You may qualify if:

  • Pregnant (28-32 weeks gestational age)
  • Speak local language
  • Personal mobile phone or willing to accept study phone
  • Able to provide informed consent

You may not qualify if:

  • Do not speak local language
  • No personal phone or unwilling to accept study phone
  • Unable to provide informed consent

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (3)

Post-Graduate Institute for Medical Education and Research

Chandīgarh, Haryana, India

RECRUITING

Sangath

Bhopal, Madhya Pradesh, India

RECRUITING

Indraprastha Institute for Information Technology

New Delhi, National Capital Territory of Delhi, India

NOT YET RECRUITING

Related Publications (1)

  • El Ayadi AM, Duggal M, Gopalakrishnan L, Bagga R, Singh P, Lin T, Bhan A, Saunik S, Verma GS, Ahuja A, Kaur J, Tugnawat D, Gujarathi S, Singh A, Khan A, Chandke D, Dhir SK, Dhakne-Palwe S, Kumar P, Patil M, Kumar S, Vasaikar N, Weil L, Diamond-Smith N. Effectiveness of Kushal Maa, a group-based mhealth interactive education and social support intervention for maternal and neonatal health outcomes: study protocol for a multisite randomised controlled trial in India. BMJ Open. 2025 Jun 27;15(6):e104213. doi: 10.1136/bmjopen-2025-104213.

MeSH Terms

Conditions

BehaviorDepression, PostpartumBreast Feeding

Condition Hierarchy (Ancestors)

Puerperal DisordersPregnancy ComplicationsFemale Urogenital Diseases and Pregnancy ComplicationsUrogenital DiseasesDepressive DisorderMood DisordersMental DisordersFeeding Behavior

Study Officials

  • Alison M El Ayadi, ScD

    University of California, San Francisco

    PRINCIPAL INVESTIGATOR
  • Nadia G Diamond-Smith, PhD

    University of California, San Francisco

    PRINCIPAL INVESTIGATOR

Central Study Contacts

Alison M El Ayadi, ScD

CONTACT

Nadia G Diamond-Smith, PhD

CONTACT

Study Design

Study Type
interventional
Phase
not applicable
Allocation
RANDOMIZED
Masking
NONE
Purpose
PREVENTION
Intervention Model
PARALLEL
Model Details: The mHealth education and social support intervention includes tailored weekly educational content via interactive voice recognition and an android application, a phone-based provider-moderated group discussion, a provider-moderated group text chat, and referral to care as needed. Individuals are enrolled into groups of 20, have two intervention sessions prenatally and then have weekly meetings through six months postpartum for a total of 26 sessions. This model will be tested against the standard of care (3 postnatal visits in the first 7 days postpartum).
Sponsor Type
OTHER
Responsible Party
SPONSOR

Study Record Dates

First Submitted

February 24, 2022

First Posted

March 7, 2022

Study Start

January 20, 2025

Primary Completion (Estimated)

May 31, 2027

Study Completion (Estimated)

May 31, 2027

Last Updated

April 1, 2026

Record last verified: 2026-03

Data Sharing

IPD Sharing
Will share

After study completion, de-identified data will be made available to other researchers upon reasonable request and completion of a data sharing agreement.

Shared Documents
STUDY PROTOCOL, SAP
Time Frame
On study completion
Access Criteria
Request of study team.

Locations