Disconnection and Unilateral Spatial Neglect

NCT05268159 | Completed

• 1 other identifier: HLJ_2022_02
• Study Type: observational
• Target: 300
• Locations: 1 country
• Sites: 1

Brief Summary

Retrospective cohort study of consecutive patients investigated in a neurorehabilitation ward after a first hemispheric stroke. Unilateral spatial Neglect (USN) and other cognitive impairments (including attention, executive functions, memory) have been assessed in routine care at the subacute phase (\<6 months). MRI scans have also been done in routine care. The study aims at linking lesion characteristics, disconnections induced and expression of the different modalities of USN

Conditions

Stroke

Keywords

Stroke; Unilateral spatial neglect; MRI; Disconnectome,; Cognition

Outcome Measures

Primary Outcomes (1)

• Assessment of peripersonal Unilateral Neglect with the BEN (Batterie d'évaluation de la negligence, Battery of tests for the quantitative assessment of unilateral neglect)

  One assessment, during the subacute phase after stroke (3 weeks to 6 months)

Secondary Outcomes (16)

• Assessment of personal Unilateral Spatial Neglect with the Fluff Test

  One assessment, during the subacute phase after stroke (3 weeks to 6 months)

• Assessment of personal Unilateral Spatial Neglect with the Comb and Razor Test

  One assessment, during the subacute phase after stroke (3 weeks to 6 months)

• Assessment of Attention with the Test of Attentional Performance

  One assessment, during the subacute phase after stroke (3 weeks to 6 months)

• Assessment of Executive Functions with the Stroop Test

  One assessment, during the subacute phase after stroke (3 weeks to 6 months)

• Assessment of Executive Functions with the Trail Making Test

  One assessment, during the subacute phase after stroke (3 weeks to 6 months)

Study Arms (1)

Stroke patients

Stroke patients admitted to the Lille Neurological rehabilitation unit after a first-ever hemispheric stroke, assessed at the subacute phase (\< 6months)

Other: Cognitive assessment

Interventions

Cognitive assessment OTHER

Assessment of unilateral spatial neglect, attention, executive functions and memory

Stroke patients

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Consecutive patients admitted in neurorehabilitation ward after first hemispheric stroke

You may qualify if:

• First hemispheric adult stroke patient
• Confirmed by MRI
• Assessment of cognitive functions during the subacute phase (3 weeks to 6 months after stroke onset

You may not qualify if:

• History of previous stroke or neurological disorders
• Inability to perform cognitive assessment due to severe comprehension, cognitive or psychiatric disorder
• Uncorrected severe loss of visual acuity
• Contra-indications to MRI

Sponsors & Collaborators

• University Hospital, Lille: lead

Study Sites (1)

Hop Swynghedauw

Lille, 59000, France

Location

MeSH Terms

Conditions

Stroke

Interventions

Mental Status and Dementia Tests

Condition Hierarchy (Ancestors)

Cerebrovascular Disorders; Brain Diseases; Central Nervous System Diseases; Nervous System Diseases; Vascular Diseases; Cardiovascular Diseases

Intervention Hierarchy (Ancestors)

Neuropsychological Tests; Psychological Tests; Behavioral Disciplines and Activities

Study Officials

• Etienne Allart, MD

  University Hospital, Lille

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: CASE ONLY
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: February 24, 2022
• First Posted: March 7, 2022
• Study Start: June 1, 2011
• Primary Completion: December 31, 2021
• Study Completion: December 31, 2021
• Last Updated: May 18, 2022

Record last verified: 2022-02

Locations

FR (1)