Atrial Fibrillation Patients Treated With Catheter Ablation

NCT05266144 | Recruiting

• 1 other identifier: PUMCH-AF
• Study Type: observational
• Target: 300
• Locations: 1 country
• Sites: 1

Brief Summary

This is a single-center prospective observational cohort study of atrial fibrillation patients treated with radiofrequency ablation.

Conditions

Atrial Fibrillation; Atrial Fibrillation Recurrent

Outcome Measures

Primary Outcomes (2)

• Recurrence assessed by ECG, Holter reports and outpatient physicians

  Recurrence includes atrial fibrillation and atrial flutter. Recurrence features including pattern, duration, burden, etc. will be recorded.

  at 1-year follow-up after ablation

• All-cause mortality assessed by telephone follow-up or medical records

  Time and cause of death will be recorded.

  at 1-year follow-up after ablation

Secondary Outcomes (4)

• Improvement in life quality assessed by QOLSF36 Questionnaire

  at 1-year follow-up after ablation

• Improvement in left atrial function assessed by echocardiography

  at 1-year follow-up after ablation

• Embolic events assessed by physicians and further examinations like ultrasound, MRI

  at 1-year follow-up after ablation

• Hospitalization for heart failure, atrial fibrillation or atrial flutter

  at 1-year follow-up after ablation

Study Arms (1)

atrial fibrillation

Atrial fibrillation patients who underwent radiofrequency ablation in Peking Union Medical College Hospital.

Procedure: radiofrequency ablation

Interventions

radiofrequency ablation PROCEDURE

Bilateral pulmonary vein isolation, a kind of radiofrequency ablation, is performed in atrial fibrillation patients for atrial arrhythmia therapy.

atrial fibrillation

Eligibility Criteria

• Age: 18 Years - 80 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Consecutive atrial fibrillation patients, who underwent catheter ablation in Peking Union Medical College Hospital, were enrolled. All patients went through bilateral pulmonary vein isolation under general or local anesthesia, and were regularly followed up at 3-month and 1-year after ablation.

You may qualify if:

• Non-valvular atrial fibrillation, including paroxysmal atrial fibrillation and persistent atrial fibrillation
• years old
• The anteroposterior diameter of the left atrium is less than 50mm via TTE
• Patient meets the intervention criteria for bilateral pulmonary vein isolation after evaluation by electrophysiological specialists
• Patient consents to ablation treatment

You may not qualify if:

• Intra-atrial thrombus detected by TEE
• Hyperthyroidism
• Previous radiofrequency ablation for atrial fibrillation

Sponsors & Collaborators

• Peking Union Medical College Hospital: lead

Study Sites (1)

Peking Union Medical College Hospital

Beijing, Beijing Municipality, 100005, China

RECRUITING

Related Publications (1)

• Sun K, Qin X, Zhang D, Fang F, Wan R, Wang J, Yu J, Lai J, Yang D, Fan J, Cheng Z, Cheng K, Gao P, Zhang L, Deng H, Fang Q, Chen T, Liu Y. HFpEF correlated with better improvement of left atrial function in post-ablation patients with paroxysmal atrial fibrillation. Int J Cardiovasc Imaging. 2025 Apr;41(4):721-732. doi: 10.1007/s10554-025-03359-0. Epub 2025 Mar 1.

  PMID: 40025277 DERIVED

Biospecimen

Retention: SAMPLES WITH DNA

Samples will be used for biochemical parameter analysis, and atrial fibrillation patients with ventricular fibrosis will be selected for gene sequencing to explore the existence of underlying cardiomyopathy.

MeSH Terms

Conditions

Atrial Fibrillation

Interventions

Radiofrequency Ablation

Condition Hierarchy (Ancestors)

Arrhythmias, Cardiac; Heart Diseases; Cardiovascular Diseases; Pathologic Processes; Pathological Conditions, Signs and Symptoms

Intervention Hierarchy (Ancestors)

Radiofrequency Therapy; Therapeutics; Ablation Techniques; Surgical Procedures, Operative

Study Officials

• Quan Fang, M.D.

  Peking Union Medical College Hospital

  STUDY CHAIR

• Yongtai Liu, M.D.

  Peking Union Medical College Hospital

  PRINCIPAL INVESTIGATOR

Central Study Contacts

Yongtai Liu, M.D.

CONTACT

+86-1069155068; ataiever@163.com

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: February 13, 2022
• First Posted: March 4, 2022
• Study Start: September 4, 2020
• Primary Completion: October 1, 2025
• Study Completion: December 31, 2025
• Last Updated: June 5, 2025

Record last verified: 2025-02

Locations

CN (1)