NCT05264051

Brief Summary

The purpose of the study is to study the muscle assessment score (MAsS, utilizing MRI, as an objective measure of frailty and muscle composition to serve as a predictor of morbidity and mortality in patients with liver disease.

Trial Health

77
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
1,200

participants targeted

Target at P75+ for all trials

Timeline
10mo left

Started Apr 2022

Longer than P75 for all trials

Geographic Reach
1 country

1 active site

Status
recruiting

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Progress83%
Apr 2022Mar 2027

First Submitted

Initial submission to the registry

February 22, 2022

Completed
9 days until next milestone

First Posted

Study publicly available on registry

March 3, 2022

Completed
2 months until next milestone

Study Start

First participant enrolled

April 18, 2022

Completed
4.9 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

March 1, 2027

Expected
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

March 1, 2027

Last Updated

January 14, 2026

Status Verified

January 1, 2026

Enrollment Period

4.9 years

First QC Date

February 22, 2022

Last Update Submit

January 12, 2026

Conditions

Liver Diseases

Outcome Measures

Primary Outcomes (1)

  • Waitlist Mortality

    Death prior to liver transplant or delisting from enrollment in the study

    Measured up to 10 years out from enrollment

Eligibility Criteria

Age18 Years+
Sexall
Healthy VolunteersNo
Age GroupsAdult (18-64), Older Adult (65+)
Sampling MethodProbability Sample
Study Population

Pts. hospitalized with acute hepatic decompensation Pts. with hepatobiliary neoplasia Pts. undergoing TIPS placement Pts. with chroinic liver disease

You may qualify if:

  • Patients who are already scheduled for an MRI for routine clinical purposes will be evaluated

You may not qualify if:

  • \<18 yrs. of age

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

The University of Chicago

Chicago, Illinois, 60637, United States

RECRUITING

MeSH Terms

Conditions

Liver Diseases

Condition Hierarchy (Ancestors)

Digestive System Diseases

Central Study Contacts

Omar Jamil, MD

CONTACT

847-373-2360Omar.Jamil@uchospitals.edu

Maria Newsome

CONTACT

773-702-2788mnewsome1@bsd.uchicago.edu

Study Design

Study Type
observational
Observational Model
CASE ONLY
Time Perspective
PROSPECTIVE
Sponsor Type
OTHER
Responsible Party
SPONSOR

Study Record Dates

First Submitted

February 22, 2022

First Posted

March 3, 2022

Study Start

April 18, 2022

Primary Completion (Estimated)

March 1, 2027

Study Completion (Estimated)

March 1, 2027

Last Updated

January 14, 2026

Record last verified: 2026-01

Locations

US(1)