NCT00011284

Brief Summary

White blood cells can cause liver damage if they inappropriately accumulate in the liver in large numbers. Such an event can occur if an individual's blood is exposed to endotoxin, a substance released from the cell walls of many species of bacteria. The purpose of this study is to isolate neutrophils, an important white blood cell, from the blood of normal volunteers, and put them in tissue culture with isolated liver cells. The experiments will determine how endotoxin can increase the ability of neutrophils to damage liver cells. All studies supported by this grant will be done with isolated cells in tissue culture. This experimental model will reveal possible mechanisms that can in the future be evaluated in human diseases such as bacterial sepsis.

Trial Health

80
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
50

participants targeted

Target at P25-P50 for all trials

Geographic Reach
1 country

1 active site

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

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Study Timeline

Key milestones and dates

First Submitted

Initial submission to the registry

February 15, 2001

Completed
4 days until next milestone

First Posted

Study publicly available on registry

February 19, 2001

Completed
9 months until next milestone

Study Completion

Last participant's last visit for all outcomes

November 1, 2001

Completed
Last Updated

June 24, 2005

Status Verified

September 1, 2002

First QC Date

February 15, 2001

Last Update Submit

June 23, 2005

Conditions

Liver Diseases

Keywords

LiverInflammationEndotoxinNeutrophilsHepatocytes

Eligibility Criteria

Age21 Years - 65 Years
Sexall
Healthy VolunteersYes
Age GroupsAdult (18-64), Older Adult (65+)
Only blood from normal subjects will be used in the in vitro experiments.

Contact the study team to discuss eligibility requirements. They can help determine if this study is right for you.

Sponsors & Collaborators

Study Sites (1)

Baylor College of Medicine

Houston, Texas, 77030, United States

Location

MeSH Terms

Conditions

Liver DiseasesInflammation

Condition Hierarchy (Ancestors)

Digestive System DiseasesPathologic ProcessesPathological Conditions, Signs and Symptoms

Study Design

Study Type
observational
Observational Model
CASE CONTROL
Time Perspective
OTHER
Sponsor Type
NIH

Study Record Dates

First Submitted

February 15, 2001

First Posted

February 19, 2001

Study Completion

November 1, 2001

Last Updated

June 24, 2005

Record last verified: 2002-09

Locations

US(1)