NCT05250180

Brief Summary

Children requiring inpatient rehabilitation treatment following acquired brain injury (ABI) are at risk for poor engagement in rehabilitative therapies. A within subject crossover design will be used to determine whether involving dogs in physical and occupational therapies while receiving inpatient rehabilitation improves patient engagement, how involving dogs improves engagement, and identify who is most likely to benefit. This project addresses the critical need to establish an evidence base for animal-assisted therapies in pediatric rehabilitation, incorporates innovative methods, and has the potential to lead to improved clinical care for children and adolescents receiving intensive rehabilitation following ABI.

Trial Health

77
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
90

participants targeted

Target at P50-P75 for not_applicable

Timeline
2mo left

Started Jul 2022

Longer than P75 for not_applicable

Geographic Reach
1 country

1 active site

Status
recruiting

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

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Study Timeline

Key milestones and dates

Study Progress96%
Jul 2022Jun 2026

First Submitted

Initial submission to the registry

January 21, 2022

Completed
1 month until next milestone

First Posted

Study publicly available on registry

February 22, 2022

Completed
5 months until next milestone

Study Start

First participant enrolled

July 22, 2022

Completed
3.7 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

April 1, 2026

Completed
3 months until next milestone

Study Completion

Last participant's last visit for all outcomes

June 30, 2026

Expected
Last Updated

May 8, 2025

Status Verified

May 1, 2025

Enrollment Period

3.7 years

First QC Date

January 21, 2022

Last Update Submit

May 5, 2025

Conditions

Keywords

Pediatric brain injuryAnimal assisted therapyinpatient rehabilitation

Outcome Measures

Primary Outcomes (2)

  • Patient Participation/engagement

    Patient engagement/participation will be assessed via the Pittsburgh Rehabilitation Participation Scale (PRPS) is a 6-item Likert-type, clinician-rated measure that quantifies observed patient participation/engagement in their therapy sessions. Therapists will report their observations regarding patient's completion of exercises, effort applied to exercises, and level of support needed to complete activities.

    throughout study completion - an average of 2 weeks

  • Objective Engagement rating.

    An objective measure of session engagement assessed via behavioral coding of video recorded therapy sessions. Coders will provide an objective measure of engagement by rating the patient in-session engagement based on the PRPS. Behaviors reflective of ratings on the PRPS will be clearly operationalized with anchors for each rating clearly defined.

    throughout study completion - an average of 2 weeks

Secondary Outcomes (5)

  • Patient-reported mood

    throughout study completion - an average of 2 weeks

  • Objective mood assessment

    throughout study completion - an average of 2 weeks

  • Automated mood assessment

    throughout study completion - an average of 2 weeks

  • Physiological distress

    throughout study completion - an average of 2 weeks

  • Salivary Oxytocin

    throughout study completion - an average of 2 weeks

Other Outcomes (2)

  • Anthropomorphism

    throughout study completion - an average of 2 weeks

  • Patient-animal rapport

    throughout study completion - an average of 2 weeks

Study Arms (2)

Intervention

EXPERIMENTAL

animal assisted therapy

Other: Animal Assisted Therapy

Control

ACTIVE COMPARATOR

Treatment as usual

Other: Control

Interventions

Patients enrolled in the study will be randomly scheduled to have a dog be a part of their PT and OT sessions on two days (one in the first week and one in the second week) during their stay. On these days, the therapist will lead the therapy session and integrate the dog at whatever level is appropriate based on the patient's level of functioning and therapy goals.

Also known as: AAT
Intervention
ControlOTHER

treatment as usual as dictated by their treatment team

Also known as: Treatment as usual
Control

Eligibility Criteria

Age4 Years - 24 Years
Sexall
Healthy VolunteersNo
Age GroupsChild (0-17), Adult (18-64)

You may qualify if:

  • Diagnosis: Participants must be admitted to the inpatient rehabilitation unit for treatment of an acquired brain injury (TBI, brain tumor, infection, etc).
  • Consent: The family must provide informed consent by parents or legal guardians.
  • Assent: The child/adolescent must provide a signature indicating assent to participate in the study.
  • Age at the time of screening: 4-21 years old
  • Sex: includes both males and females
  • Responsiveness: Rancho score greater than 2 at the time of enrollment (as noted in the medical chart).

You may not qualify if:

  • Allergies: Patient has a significant allergy to dogs
  • Fear: Patient has a significant fear of dogs
  • Disease: Participant is on contact precautions or has a communicable disease that may pose a risk to the dog or dog handler or has a compromised immune system where interacting with the dog and/or handler would be of significant risk to the patient.
  • Medical History: History of developmental delay prior to ABI.
  • Behavioral History: Participant or family has a history of animal abuse or cruelty.
  • Responsiveness: Rancho score of 2 or less

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

Cincinnati Children's Hospital Medical Center

Cincinnati, Ohio, 45229, United States

RECRUITING

MeSH Terms

Conditions

Brain Injuries

Interventions

Animal Assisted TherapyTherapeutics

Condition Hierarchy (Ancestors)

Brain DiseasesCentral Nervous System DiseasesNervous System DiseasesCraniocerebral TraumaTrauma, Nervous SystemWounds and Injuries

Intervention Hierarchy (Ancestors)

RehabilitationAftercareContinuity of Patient CarePatient CarePhysical Therapy ModalitiesPsychotherapyBehavioral Disciplines and ActivitiesHealth ServicesHealth Care Facilities Workforce and Services

Central Study Contacts

Megan Narad, PhD

CONTACT

Study Design

Study Type
interventional
Phase
not applicable
Allocation
RANDOMIZED
Masking
SINGLE
Who Masked
OUTCOMES ASSESSOR
Purpose
TREATMENT
Intervention Model
CROSSOVER
Sponsor Type
OTHER
Responsible Party
SPONSOR

Study Record Dates

First Submitted

January 21, 2022

First Posted

February 22, 2022

Study Start

July 22, 2022

Primary Completion

April 1, 2026

Study Completion (Estimated)

June 30, 2026

Last Updated

May 8, 2025

Record last verified: 2025-05

Locations