Acute Impact of Different Foods and Beverages on Exercise Induced Oxidative Stress and Inflammation

NCT05242978 | Completed

• 1 other identifier: 2021-00743
• Study Type: interventional
• Target: 42
• Locations: 1 country
• Sites: 1

Brief Summary

The aim of this research project is to explore the acute impact of specific foods and beverages, which have been shown to be associated with inflammatory processes, mainly in epidemiological studies, on inflammatory and oxidative stress parameters in healthy humans following a high intensity physical workout.

Conditions

Inflammatory Response; Oxidative Stress; Oxidative Stress Induction

Outcome Measures

Primary Outcomes (2)

• ROS change

  ROS (change from baseline = after overnight fasting to post exercise (=after 2.5 hours)

  change from baseline to 2.5 hours

• IL-6 change

  IL-6 (change from baseline = after overnight fasting to post exercise (=after 2.5 hours)

  change from baseline to 2.5 hours

Secondary Outcomes (8)

• estradiol

  baseline

• DNA damage (comet assay

  change from baseline to 2.5 hours

• MDA change

  change from baseline to 2.5 hours

• hs-CRP change

  change from baseline to 2.5 hours

• FRAP

  change from baseline to 2.5 hours

Study Arms (2)

Impact of GT, coffee, OJ, PGJ, milk, SSB on exercise induced oxidative stress&inflammation

EXPERIMENTAL

single consumption of one cup of green tea (GT), coffee, orange juice (OJ), pomegranate juice (PGJ), milk and sugar sweetened beverage (SSB) 2 hours prior to a 30-min- HIIT resistance circuit exercise in healthy human subjects

Other: Nutrition

Impact of choc, bcc, fl-oil, blueb., r&w bread on exercise induced oxidative stress&inflammation

EXPERIMENTAL

single consumption of one proportion of dark chocolate (choc), broccoli (bcc), flaxseed oil, blueberries, white bread and whole grain bread (r = refined \& w = whole grain) 2 hours prior to a 30-min-HIIT resistance circuit exercise in healthy human subjects

Other: Nutrition

Interventions

Nutrition OTHER

acute single dose nutrition intervention

Impact of GT, coffee, OJ, PGJ, milk, SSB on exercise induced oxidative stress&inflammation; Impact of choc, bcc, fl-oil, blueb., r&w bread on exercise induced oxidative stress&inflammation

Eligibility Criteria

• Age: 18 Years - 40 Years
• Sex: female
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• female human subjects
• aged 18-40 years
• no chronical diseases
• not more than 120 minutes of physical activity per week
• no regular resistance training within the past 6 months
• BMI 18.5 - 24.99 kg/m²
• body fat percentage of at least 20%

You may not qualify if:

• contraindications against physical activity
• anemia
• fructose or lactose intolerance
• smoking
• medications with influence on ROS levels or inflammation
• allergy or intolerance against intervention food/beverages.

Sponsors & Collaborators

• University of Vienna: lead

Study Sites (1)

University of Vienna

Vienna, Austria, 1070, Austria

Location

MeSH Terms

Interventions

Nutritional Status

Intervention Hierarchy (Ancestors)

Nutritional Physiological Phenomena; Diet, Food, and Nutrition; Physiological Phenomena; Health Status; Demography; Population Characteristics

Study Officials

• Markus Gassner, MSc

  University Assistant

  PRINCIPAL INVESTIGATOR

• Daniel König, Univ Prof

  Professor of sports nutrition

  STUDY DIRECTOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: NONE
• Purpose: PREVENTION
• Intervention Model: CROSSOVER
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Principal Investigator

Model Details: acute consumption of anti- and pro- inflammatory foods (n=22) and beverages (n=20) 2 hour prior to intense physical activity in healthy female subjects (in total 42 subjects)

Study Record Dates

• First Submitted: January 26, 2022
• First Posted: February 16, 2022
• Study Start: May 17, 2022
• Primary Completion: April 30, 2024
• Study Completion: April 30, 2024
• Last Updated: July 4, 2025

Record last verified: 2024-11

Data Sharing

• IPD Sharing: Will not share

Locations

AU (1)