Imbalances of Regional Pulmonary Ventilation in Patients With Post-acute-COVID-19

NCT05238623 | Not Yet Recruiting

• 1 other identifier: KIM-IV-EIT03
• Study Type: observational
• Target: 50
• Locations: 1 country
• Sites: 1

Brief Summary

Investigation of the correlation of CT-morphological changes of the lung compared to regional ventilation distribution on electrical impedance tomography in patients with post-acute-Covid-19 symptoms.

Conditions

COVID-19 Pneumonia; Post-acute COVID-19 Syndrome; Electric Impedance

Keywords

Electric Impedance; CT; Tomography; regional ventilation; post-acute-COVID-19 syndrome; post-COVID-19; EIT; electroimpedance tomography; long-COVID

Outcome Measures

Primary Outcomes (1)

• Correlation between tomography and electroimpedance tomography

  The primary study objective is to match CT morphological changes in regional ventilation in post-COVID patients and/or changes in lung function examination with changes that can be visualized by electroimpedance tomography.

  until May 2022

Secondary Outcomes (1)

• Correlation between lung function testing and electroimpedance tomography

  until May 2022

Study Arms (2)

Control cohort

lung-healthy volunteers get a EIT measurement

Case cohort

Patients who receive standard CT and pulmonary function testing also receive electroimpedance tomography measurement

Diagnostic Test: additional EIT Measurement

Interventions

additional EIT Measurement DIAGNOSTIC_TEST

Patients who receive standard CT and pulmonary function testing also receive electroimpedance tomography measurement. The lunghealthy Patients in the control group only receive a EIT.

Case cohort

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

All patients presenting to the post-COVID-19 outpatient clinic are screened.

You may qualify if:

• all patients undergoing a Chest CT due to suspected post-acute-Covid-19-syndrome
• \>18 years
• informed consent.

You may not qualify if:

• trauma patients and patients with unstable spinal injuries or fractures
• patients with an BMI over 50
• patients with uncontrolled body movements
• Patients with a pacemaker

Sponsors & Collaborators

• Jan-Christoph Lewejohann: lead

Study Sites (1)

Klinik für Notfallmedizin

Jena, Thuringia, 07747, Germany

Location

MeSH Terms

Conditions

Post-Acute COVID-19 Syndrome

Condition Hierarchy (Ancestors)

COVID-19; Pneumonia, Viral; Pneumonia; Respiratory Tract Infections; Infections; Virus Diseases; Coronavirus Infections; Coronaviridae Infections; Nidovirales Infections; RNA Virus Infections; Lung Diseases; Respiratory Tract Diseases; Post-Infectious Disorders; Chronic Disease; Disease Attributes; Pathologic Processes; Pathological Conditions, Signs and Symptoms

Study Officials

• Phillip A Reuken, Dr.

  Jena University Hospital, Klinik für Innere Medizin IV

  STUDY DIRECTOR

Central Study Contacts

Jan-Christoph Lewejohann, Dr.

CONTACT

+49 3641 9 32 20 13; jan-christoph.lewejohann@med.uni-jena.de

Phillip A. Reuken, Dr.

CONTACT

+49 3641 9 32 4504; Philipp.reuken@med.uni-jena.de

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR INVESTIGATOR
• PI Title: Investigator

Study Record Dates

• First Submitted: February 8, 2022
• First Posted: February 14, 2022
• Study Start: October 1, 2025
• Primary Completion (Estimated): June 30, 2026
• Study Completion (Estimated): March 31, 2027
• Last Updated: September 25, 2025

Record last verified: 2025-09

Locations

DE (1)