Better Understand Motor Deficits Associated With Autism Spectrum Disorders: Development of an Assessment Protocol

NCT05236803 | Recruiting

• 1 other identifier: 2021-A02426-35
• Study Type: interventional
• Target: 110
• Locations: 1 country
• Sites: 4

Brief Summary

This research is a case-control study aiming to characterize motor peculiarities (objective quantitative and qualitative measures) and its psycho-physiological correlates of children with ASD.

Conditions

Autism Spectrum Disorder

Keywords

Autisme Spectrum Disorders; Motricity; Cognitive disorders; Behaviour; motor skill differences

Outcome Measures

Primary Outcomes (3)

• Measurement performance of fine motor skills (graphics, pointing task)

  Jointly and in an automated and standardized manner, measure performance in the context of tasks measuring the performance and patterns of general motor skills (postures, walking, overall coordination), fine motor skills (graphics, pointing task) and oculomotricity (visual orientation and control).

  At 3 month

• Measurement performance of general motor skills with biomechanical analysis

  Jointly and in an automated and standardized manner, measure motor patterns in the context of tasks measuring the performance and patterns of general motor skills (postures, walking, overall coordination), fine motor skills (graphics, pointing task) and oculomotricity (visual orientation and control).

  At 3 month

• Measurement of oculomotricity with eye-tracking system (visual orientation and control)

  Jointly and in an automated and standardized manner, motor patterns in the context of tasks measuring the performance and patterns of general motor skills (postures, walking, overall coordination), fine motor skills (graphics, pointing task) and oculomotricity (visual orientation and control).

  At 3 month

Secondary Outcomes (7)

• Motor performance : success, error rate (%)

  At visit 1 and visit 2, an average of 3 months

• Motor performance : task duration (ms), reaction time (ms) and latency (ms)

  At visit 1 and visit 2, an average of 3 months

• IQ as assessed using WISC IV

  At visit 1 and visit 2, an average of 3 months

• Score of socio-communicative skills as assessed using Social Responsiveness Scale

  At visit 1 and visit 2, an average of 3 months

• ADHD as assessed using Conners-3

  At visit 1 and visit 2, an average of 3 months

Study Arms (1)

Epidemiology

OTHER

Recording of participant's performance during eye, fine motor and gross motor tests Passing self and hetero questionnaires.

Behavioral: Testing of general motor skills, fine motor skills and occulomotricity; Behavioral: Questionnaires

Interventions

Questionnaires BEHAVIORAL

Passing self and hetero questionnaires.

Epidemiology

Testing of general motor skills, fine motor skills and occulomotricity BEHAVIORAL

Recording of participant's performance during eye, fine motor and gross motor tests; Children's gross motor skills will be assessed through a biomechanical analysis. Eye movements will be recorded using the eye-tracking system (Tobii Pro TX300). The technique used is the corneal reflection technique.

Epidemiology

Eligibility Criteria

• Age: 6 Years - 11 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Child (0-17)

You may qualify if:

• All participants :
• Be between 6 and 11 years old
• Mastery of the French language
• Be affiliated with a Social Security scheme or benefit from affiliation by a third person
• Both parents (or the holder of legal authority) have read, understood and signed the study consent
• Be affiliated with social security
• Being diagnosed with ASD (DSM-V)

You may not qualify if:

• All participants :
• Refusal to participate in the research on the part of the participant and / or holders of parental authority.
• Be a person benefiting from enhanced protection, namely : persons deprived of their liberty by a judicial or administrative decision, persons staying in a health or social establishment.
• Have uncorrected visual or hearing problems
• To have concomitant psychotropic drug treatments not stabilized, initiated in the last 2 months: antipsychotics, mood stabilizers, anti-epileptics, psychostimulants, antidepressants.
• Have a motor handicap of the upper or lower limbs, fitted or not.
• Have diagnosed neurological or psychiatric disorders, present a general or metabolic pathology having a known impact on the child's motor skills (eg: Epilepsy, Tics and Gilles de la Tourette Syndrome, Intellectual Deficiency, Neuromuscular Syndrome, Metabolic Neurological Syndrome , neoplasms)
• Suspicion of low intellectual efficiency if at least one of the two subtests (Similarities or Matrices) of WISC V (retrieved from the medical file if the TSA participant) presents a result (standard score) strictly lower than 7.
• Participants without ASD :
• Participant with ADHD (Attention Deficit Disorder with or without Hyperactivity) or CDD (Developmental Coordination Disorder)

Sponsors & Collaborators

• Centre Hospitalier Charles Perrens, Bordeaux: lead

Study Sites (4)

Centre Hospitalier Charles Perrens

Bordeaux, 33076, France

RECRUITING

Centre Hospitalier La Rochelle Re Aunis

La Rochelle, 17019, France

RECRUITING

CHU de LIMOGES

Limoges, 87042, France

RECRUITING

Centre Hospitalier Henri Laborit

Poitiers, 86021, France

RECRUITING

Related Publications (5)

• Biffi E, Costantini C, Ceccarelli SB, Cesareo A, Marzocchi GM, Nobile M, Molteni M, Crippa A. Gait Pattern and Motor Performance During Discrete Gait Perturbation in Children With Autism Spectrum Disorders. Front Psychol. 2018 Dec 11;9:2530. doi: 10.3389/fpsyg.2018.02530. eCollection 2018.

  PMID: 30618953 RESULT

• Cazalets JR, Bestaven E, Doat E, Baudier MP, Gallot C, Amestoy A, Bouvard M, Guillaud E, Guillain I, Grech E, Van-Gils J, Fergelot P, Fraisse S, Taupiac E, Arveiler B, Lacombe D. Evaluation of Motor Skills in Children with Rubinstein-Taybi Syndrome. J Autism Dev Disord. 2017 Nov;47(11):3321-3332. doi: 10.1007/s10803-017-3259-1.

  PMID: 28748333 RESULT

• D'Mello AM, Stoodley CJ. Cerebro-cerebellar circuits in autism spectrum disorder. Front Neurosci. 2015 Nov 5;9:408. doi: 10.3389/fnins.2015.00408. eCollection 2015.

  PMID: 26594140 RESULT

• Eggleston JD, Harry JR, Cereceres PA, Olivas AN, Chavez EA, Boyle JB, Dufek JS. Lesser magnitudes of lower extremity variability during terminal swing characterizes walking patterns in children with autism. Clin Biomech (Bristol). 2020 Jun;76:105031. doi: 10.1016/j.clinbiomech.2020.105031. Epub 2020 May 7.

  PMID: 32408186 RESULT

• Hak L, Houdijk H, Beek PJ, van Dieen JH. Steps to take to enhance gait stability: the effect of stride frequency, stride length, and walking speed on local dynamic stability and margins of stability. PLoS One. 2013 Dec 13;8(12):e82842. doi: 10.1371/journal.pone.0082842. eCollection 2013.

  PMID: 24349379 RESULT

MeSH Terms

Conditions

Autism Spectrum Disorder; Cognitive Dysfunction; Behavior

Interventions

Surveys and Questionnaires

Condition Hierarchy (Ancestors)

Child Development Disorders, Pervasive; Neurodevelopmental Disorders; Mental Disorders; Cognition Disorders; Neurocognitive Disorders

Intervention Hierarchy (Ancestors)

Data Collection; Epidemiologic Methods; Investigative Techniques; Health Care Evaluation Mechanisms; Quality of Health Care; Health Care Quality, Access, and Evaluation; Public Health; Environment and Public Health

Study Officials

• Anouck AMESTOY, MD

  Physician

  STUDY DIRECTOR

Central Study Contacts

Anouck AMESTOY, MD

CONTACT

05 56 56 67 19; aamestoy@ch-perrens.fr

Helen SAVARIEAU

CONTACT

05 56 56 35 56; hsavarieau@ch-perrens.fr

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NA
• Masking: NONE
• Purpose: OTHER
• Intervention Model: SINGLE GROUP
• Sponsor Type: OTHER GOV
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: December 15, 2021
• First Posted: February 11, 2022
• Study Start: February 7, 2022
• Primary Completion (Estimated): October 30, 2026
• Study Completion (Estimated): March 31, 2027
• Last Updated: March 16, 2026

Record last verified: 2026-03

Data Sharing

• IPD Sharing: Will not share

Locations

FR (4)