Effects of Virtual Reality Based Games in Rehabilitation of Parkinson's Disease

NCT05235880 | Completed

• 1 other identifier: KA-21067
• Study Type: interventional
• Target: 20
• Locations: 1 country
• Sites: 1

Brief Summary

The purpose of this study is to investigate the effects of virtual reality based games on upper extremities, trunk and cognitive functions in patients with Parkinson's Disease.

Conditions

Parkinson Disease

Keywords

parkinson disease; physiotherapy; exergames

Outcome Measures

Primary Outcomes (4)

• Upper extremities performance with 9 hole peg test

  The patient sits with a table in front of him/her and places 9 small wooden sticks on the surface with nine holes on them, takes them out again and lays them on his/her side. He/she is asked to do it as quickly as possible and his/her time is saved

  Change from Baseline at 8 weeks

• Upper extremities performance with Minnesota Manual Dexterity Test

  It involves taking small disc-shaped objects, each of standard size, to different distances on the table in the shortest possible time and placing them in sequence, while the patient is in a sitting position with a table in front of him/her.

  Change from Baseline at 8 weeks

• Cognitive Status with Montreal Cognitive Assessment

  its validity and reliability in Turkish have been established. The total score ranges from 0-30, and a higher score indicates a better cognitive status. Below 21 points indicates cognitive impairment.

  Change from Baseline at 8 weeks

• Trunk Functions with Trunk Impairment Scale

  It is a valid and reliable scale for evaluating the motor disorders and balance of the trunk in Parkinson's patients. The total score in the scale, which consists of 17 items in 3 sections, ranges from 0 to 23. A higher score indicates better trunk function and balance.

  Change from Baseline at 8 weeks

Secondary Outcomes (4)

• Dynamic balance with functional reach test

  Change from Baseline at 8 weeks

• Balance and mobility with Timed Up and Go Test

  Change from Baseline at 8 weeks

• Quality of life with Parkinson's Disease Questionnaire

  Change from Baseline at 8 weeks

• Disease severity and symptoms with Unified Parkinson Disease Rating Scale Part 2 and 3

  Change from Baseline at 8 weeks

Study Arms (2)

study group

EXPERIMENTAL

1 hour physiotherapy session for 3 times a week and 8 weeks in total.

Other: Virtual reality based games

control group

ACTIVE COMPARATOR

1 hour physiotherapy session for 3 times a week and 8 weeks in total.

Other: Conventional exercises

Interventions

Virtual reality based games OTHER

In an hour physiotherapy session first 40 minutes of session includes conventional physiotherapy program tailored to patient's needs. Last 20 minutes of session includes virtual reality based games aiming improvement on upper extremities, trunk and cognitive functions.

study group

Conventional exercises OTHER

In an hour physiotherapy session first 40 minutes of session includes conventional physiotherapy program tailored to patient's needs. Last 20 minutes of session includes conventional physiotherapy approaches aiming improvement on upper extremities, trunk and cognitive functions.

control group

Eligibility Criteria

• Age: 50 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Diagnosed with Parkinson's disease
• years old and over
• Stage 1.5-3 according to the modified Hoehn-Yahr Staging Scale
• Mini mental test score of 24 and above

You may not qualify if:

• Additional neurological disease or symptom other than Parkinson's disease
• Orthopedic disorder that will prevent them from doing exercises
• Severe mental disorders

Sponsors & Collaborators

• Hacettepe University: lead

Study Sites (1)

Hacettepe University

Ankara, Turkey (Türkiye)

Location

Related Publications (6)

• Kalia LV, Lang AE. Parkinson's disease. Lancet. 2015 Aug 29;386(9996):896-912. doi: 10.1016/S0140-6736(14)61393-3. Epub 2015 Apr 19.

  PMID: 25904081 BACKGROUND

• Jankovic J. Parkinson's disease: clinical features and diagnosis. J Neurol Neurosurg Psychiatry. 2008 Apr;79(4):368-76. doi: 10.1136/jnnp.2007.131045.

  PMID: 18344392 BACKGROUND

• Abbruzzese G, Marchese R, Avanzino L, Pelosin E. Rehabilitation for Parkinson's disease: Current outlook and future challenges. Parkinsonism Relat Disord. 2016 Jan;22 Suppl 1:S60-4. doi: 10.1016/j.parkreldis.2015.09.005. Epub 2015 Sep 3.

  PMID: 26360239 BACKGROUND

• Allen NE, Song J, Paul SS, Smith S, O'Duffy J, Schmidt M, Love R, Sherrington C, Canning CG. An interactive videogame for arm and hand exercise in people with Parkinson's disease: A randomized controlled trial. Parkinsonism Relat Disord. 2017 Aug;41:66-72. doi: 10.1016/j.parkreldis.2017.05.011. Epub 2017 May 15.

  PMID: 28528804 BACKGROUND

• Levin MF. Can virtual reality offer enriched environments for rehabilitation? Expert Rev Neurother. 2011 Feb;11(2):153-5. doi: 10.1586/ern.10.201. No abstract available.

  PMID: 21306202 BACKGROUND

• Cetin B, Kilinc M, Cakmakli GY. The effects of exergames on upper extremity performance, trunk mobility, gait, balance, and cognition in Parkinson's disease: a randomized controlled study. Acta Neurol Belg. 2024 Jun;124(3):853-863. doi: 10.1007/s13760-023-02451-3. Epub 2024 Jan 5.

  PMID: 38182919 DERIVED

MeSH Terms

Conditions

Parkinson Disease

Condition Hierarchy (Ancestors)

Parkinsonian Disorders; Basal Ganglia Diseases; Brain Diseases; Central Nervous System Diseases; Nervous System Diseases; Movement Disorders; Synucleinopathies; Neurodegenerative Diseases

Study Officials

• Gül Yalçın Çakmaklı, Assoc. Prof.

  Hacettepe University

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: NONE
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Associate Professor

Study Record Dates

• First Submitted: December 22, 2021
• First Posted: February 11, 2022
• Study Start: April 15, 2022
• Primary Completion: June 15, 2023
• Study Completion: June 15, 2023
• Last Updated: September 21, 2023

Record last verified: 2023-09

Data Sharing

• IPD Sharing: Will not share

Locations

TU (1)