Loading search results
RESPECT
Exploratory Multicentre Clinical Study to Assess Repeatibility, Reproducibility, Acceptability and Clinical Validity of Multiparametric Renal Magnetic Resonance Imaging
Sponsor study identifier
interventional
140
4 countries
4
Study Start
November 25, 2022
Actual (reported)Primary Completion
March 13, 2025
Actual (reported)Study Completion
December 2025
Estimated (date passed)This estimate has passed. The registry has not confirmed an actual date for this milestone.
Chronic kidney disease (CKD) is a global health concern because more than 10% of the world's population have it, its prevalence is increasing, and CKD is an important contributor to morbidity and mortality for this population. The majority of the people with CKD aren't aware and there are not available tools for early CKD detection and for an accurate prediction on these patients. Many CKD patients exhibit progressive renal dysfunction, demonstrating a failure of current, non-specific therapeutic strategies. Better methods are urgently needed for i) early diagnosis of CKD, and prediction of its progression for improved stratification of patients and better targeting of current treatments; and ii) to directly assess structural and functional responses of the kidney to new therapies and identify those patients who respond. Over the past decade, renal Magnetic Resonance Imaging (MRI) has emerged as a promising technique for improved understanding and characterisation of renal pathophysiology. Compared to histopathology, MRI is non-invasive and avoids sampling bias by characterising the entire kidney with high spatial resolution. In spite of a number of single centre studies showing renal MRI feasibility and potential to address a number of key clinical questions, current methodological differences across studies hinder reliable comparisons of the results, which can only be regarded as preliminary. Standardization of acquisition and processing protocols across centres is therefore needed, and this will also lead to the possibility to provide preliminary data of the multiparametric renal MRI clinical validity and utility. The purpose of this study is to standardize, assess the feasibility and provide preliminary evidence of clinical validity and utility of the multiparametric renal MRI. To reach this goal two groups of subjects are involved:
Registry-reported information. Elapsed time and enrollment totals alone do not measure study progress or recruitment pace.
December 2025
Estimated (date passed)This estimate has passed. The registry has not confirmed an actual date for this milestone.
Click on a node to explore related trials.
Some registry-reported names shown below are not yet linked in this graph.
Dates and qualifiers reported by the registry. Estimated dates do not confirm that a milestone has occurred.
January 14, 2022
Actual (reported)February 8, 2022
Actual (reported)November 25, 2022
Actual (reported)March 13, 2025
Actual (reported)December 2025
Estimated (date passed)This estimate has passed. The registry has not confirmed an actual date for this milestone.
GROUP 1: within subject total kidney volume coefficient of variation in few hour time
Within subject coefficient of variation of measures computed by multiparametric renal MRI repeated in few hour time to assess total kidney volume repeatability in the whole group of healthy volunteers
At day 0
GROUP 1: within subject total kidney volume coefficient of variation after 1-2 weeks
Within subject coefficient of variation of measures computed by multiparametric renal MRI repeated after 1-2 weeks to assess total kidney volume reproducibility in the whole group of healthy volunteers
At day 7-14
GROUP 1: within subject renal artery blood flow coefficient of variation in few hour time
Within subject coefficient of variation of measures computed by multiparametric renal MRI repeated in few hour time to assess renal artery blood flow repeatability in the whole group of healthy volunteers
At day 0
GROUP 1 - within subject renal total kidney volume coefficient of variation in few hour time by gender
At day 0
GROUP 1 - within subject renal artery blood flow coefficient of variation in few hour time by gender
At day 0
GROUP 1 - within subject cortical perfusion coefficient of variation in few hour time by gender
At day 0
GROUP 1 - within subject cortical and medullary T1 coefficient of variation in few hour time by gender
At day 0
GROUP 1 - within subject cortical and medullary T2 coefficient of variation in few hour time by gender
At day 0
MRI is performed in a single multiparametric scan session with no need for contrast agents, and to depict changes in tissue microstructure associated with inflammation and fibrosis plus alterations in oxygenation.
Registry-reported names are shown in full. Names without a link have not yet been matched to a Syfrah profile.
Aarhus University Hospital, Department of Renal Medicine
Århus N, Århus N, 8200, Denmark
University Medical Center Mannheim, Medical Faculty Mannheim, Heidelberg University
Heidelberg, Mannheim, Germany
Centro di Ricerche Cliniche per le Malattie Rare "Aldo e Cele Daccò"
Ranica, BG, 24020, Italy
Clínica Universidad de Navarra
Pamplona, Navarre, 31008, Spain
Giuseppe Remuzzi, MD
Istituto Di Ricerche Farmacologiche Mario Negri
First Submitted
January 14, 2022
First Posted
February 8, 2022
Study Start
November 25, 2022
Actual (reported)Primary Completion
GROUP 1: within subject renal artery blood flow coefficient of variation after 1-2 weeks
Within subject coefficient of variation of measures computed by multiparametric renal MRI repeated after 1-2 weeks to assess renal artery blood flow reproducibility in the whole group of healthy volunteers
At day 7-14
GROUP 1: within subject cortical perfusion coefficient of variation in few hour time
Within subject coefficient of variation of measures computed by multiparametric renal MRI repeated in few hour time to assess cortical perfusion repeatability in the whole group of healthy volunteers
At day 0
GROUP 1: within subject cortical perfusion coefficient of variation after 1-2 weeks
Within subject coefficient of variation of measures computed by multiparametric renal MRI repeated after 1-2 weeks to assess cortical perfusion reproducibility in the whole group of healthy volunteers
At day 7-14
GROUP 1: within subject cortical and medullary T1 coefficient of variation in few hour time
Within subject coefficient of variation of measures computed by multiparametric renal MRI repeated in few hour time to assess cortical and medullary T1 repeatability in the whole group of healthy volunteers
At day 0
GROUP 1: within subject cortical and medullary T1 coefficient of variation after 1-2 weeks
Within subject coefficient of variation of measures computed by multiparametric renal MRI repeated after 1-2 weeks to assess cortical and medullary T1 reproducibility in the whole group of healthy volunteers
At day 7-14
GROUP 1: within subject cortical and medullary T2 coefficient of variation in few hour time
Within subject coefficient of variation of measures computed by multiparametric renal MRI repeated in few hour time to assess cortical and medullary T2 repeatability in the whole group of healthy volunteers
At day 0
GROUP 1: within subject cortical and medullary T2 coefficient of variation after 1-2 weeks
Within subject coefficient of variation of measures computed by multiparametric renal MRI repeated after 1-2 weeks to assess cortical and medullary T2 reproducibility in the whole group of healthy volunteers
At day 7-14
GROUP 1: within subject cortical and medullary R2* coefficient of variation in few hour time
Within subject coefficient of variation of measures computed by multiparametric renal MRI repeated in few hour time to assess cortical and medullary R2\* repeatability in the whole group of healthy volunteers
At day 0
GROUP 1: within subject cortical and medullary R2* coefficient of variation after 1-2 weeks
Within subject coefficient of variation of measures computed by multiparametric renal MRI repeated after 1-2 weeks to assess cortical and medullary R2\* reproducibility in the whole group of healthy volunteers
At day 7-14
GROUP 1: within subject cortical and medullary ADC coefficient of variation in few hour time
Within subject coefficient of variation of measures computed by multiparametric renal MRI repeated in few hour time to assess cortical and medullary ADC repeatability in the whole group of healthy volunteers
At day 0
GROUP 1: within subject cortical and medullary ADC coefficient of variation after 1-2 weeks
Within subject coefficient of variation of measures computed by multiparametric renal MRI repeated after 1-2 weeks to assess cortical and medullary ADC reproducibility in the whole group of healthy volunteers
At day 7-14
GROUP 2 - Percentage of complete renal MRI data collection and analysis
Percentage of complete renal MRI data acquired and generated by MRI data processing in the whole group of CKD patients, to assess feasibility of multiparametric renal MRI in CKD patients
At day 0
Contact the study team to confirm eligibility.
March 13, 2025
Study Completion
December 2025
Estimated (date passed)This estimate has passed. The registry has not confirmed an actual date for this milestone.
Last Updated
March 26, 2025
Record last verified: 2025-03
Download the complete ClinicalTrials.gov record imported by Syfrah, including fields not shown in this page. The registry may contain a newer revision.
Source: ClinicalTrials.gov.
JSON downloads include source attribution and retrieval details alongside the unchanged original record or the separately normalized values.
Source retrieved: