Intensive Psychotherapy for Chronic Depression

NCT05221567 | Completed

• 1 other identifier: ModumBad chronic depression
• Study Type: interventional
• Target: 280
• Locations: 0 countries
• Sites: N/A

Brief Summary

The study evaluates whether Intensive psychotherapy show superior effect on chronic depression over TAU

Conditions

Chronic Depression; Persistent Depressive Disorder; Recurrent Major Depression

Outcome Measures

Primary Outcomes (1)

• Change in Depressive symptoms

  Beck depression inventory II (BDI-II) Self-report instrument for assessing severity of depression. 21 items are scored on Likert scale from 0 to 4 (range 0-63). Scores between 14 and 19 indicate mild depression, 20 to 28 indicate moderate depression, and above 29 indicate major depression.

  Patients were assessed at four time points; assessment, start of therapy (12 weeks after assessment), end of therapy (24 weeks after assessment) and at 1-year follow-up (76 weeks after assessment).

Study Arms (3)

High intensity high dosage inpatient short-term psychodynamic psychotherapy (affect phobia therapy)

ACTIVE COMPARATOR

APT and VITA psychotherapy was carried out in accordance with treatment manuals. In addition to weekly individual sessions the inpatient program at both groups contained two 75 min group sessions each week. In addition, VITA had shorter group meetings each morning (15 minutes). Patients in both treatments participated in two physical exercise sessions per week, weekly psycho-educational lectures and art-therapy groups, and both groups finish each week with end of the week status groups. On average, patients in both treatments received seven sessions of therapeutic activity each week. All treatment components, with the exception of the physical exercises, adhered to the APT or VITA treatments, and thus the two intensive treatments were similar in dose but different in content. Medication was managed by psychiatrists, aiming to optimize the psychotropic medication regime, typically by reducing medication use.

Behavioral: Psychotherapy

Treatment-as-usual

OTHER

TAU through public services locally, either outpatient treatment from a psychologist/psychiatrist and/or treatment/support from their local general practitioner.

Behavioral: Psychotherapy

High intensity high dosage inpatient short-term psychodynamic psychotherapy (VITA)

ACTIVE COMPARATOR

APT and VITA psychotherapy was carried out in accordance with treatment manuals. In addition to weekly individual sessions the inpatient program at both groups contained two 75 min group sessions each week. In addition, VITA had shorter group meetings each morning (15 minutes). Patients in both treatments participated in two physical exercise sessions per week, weekly psycho-educational lectures and art-therapy groups, and both groups finish each week with end of the week status groups. On average, patients in both treatments received seven sessions of therapeutic activity each week. All treatment components, with the exception of the physical exercises, adhered to the APT or VITA treatments, and thus the two intensive treatments were similar in dose but different in content. Medication was managed by psychiatrists, aiming to optimize the psychotropic medication regime, typically by reducing medication use.

Behavioral: Psychotherapy

Interventions

Psychotherapy BEHAVIORAL

Intensive psychotherapy (i.e., greater number of treatment sessions per time unit)

High intensity high dosage inpatient short-term psychodynamic psychotherapy (VITA); High intensity high dosage inpatient short-term psychodynamic psychotherapy (affect phobia therapy); Treatment-as-usual

Eligibility Criteria

• Age: 18 Years - 70 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Persistent depressive disorder as defined by the diagnostic and statistical manual of mental disorders (DSM5)
• Recurrent depressive disorder as defined by the International classification of diseases-10 (ICD-10)

You may not qualify if:

• Not having utilized reasonably available treatment in proximity to their residence
• A psychotic disorder
• Cluster A or B personality disorder
• Bipolar disorder,
• Ongoing substance abuse,
• Physical brain disorder
• Not having access to TAU while on the 12 week wait-list period.

Sponsors & Collaborators

• Modum Bad: lead

Related Publications (1)

• Eielsen M, Ulvenes PG, Rossberg JI, Hostmaelingen A, Soma CS, Wampold BE. The Effectiveness of an Intensive Inpatient Psychotherapy Program for Chronic Depression: A naturalistic comparison with wait list. BMC Psychiatry. 2022 Nov 30;22(1):745. doi: 10.1186/s12888-022-04381-5.

  PMID: 36451114 DERIVED

MeSH Terms

Conditions

Depressive Disorder, Major

Interventions

Psychotherapy

Condition Hierarchy (Ancestors)

Depressive Disorder; Mood Disorders; Mental Disorders

Intervention Hierarchy (Ancestors)

Behavioral Disciplines and Activities

Study Officials

• KariAnne Vrabel, PhD

  Leader Modum Bad Research Institute

  STUDY DIRECTOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NON RANDOMIZED
• Masking: SINGLE
• Who Masked: INVESTIGATOR
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: January 21, 2022
• First Posted: February 3, 2022
• Study Start: January 1, 2012
• Primary Completion: December 31, 2017
• Study Completion: December 31, 2017
• Last Updated: February 3, 2022

Record last verified: 2022-02

Data Sharing

• IPD Sharing: Will not share