The Effects of Miminal Stimulation Protocol on Preimplantation Genetic Screening

NCT05220995 | Unknown DMC

• 1 other identifier: 31.01.2022
• Study Type: observational
• Target: 200
• Locations: 1 country
• Sites: 2

Brief Summary

PGS has been the most effective method for embryo selection in IVF cycles. Euploidy rates decrease significantly with advancing maternal age (AMA). The dosage of gonadotropins also may be increased to recruit an adequate number of follicles in AMA women, minimal Stimulation Protocol (MSP) with the new combination of human menopausal gonadotrophin (hMG) and clomiphene citrate (CC) for controlled ovarian hyperstimulation is defined for poor ovarian response women. The aim of this study is to show minimal stimulation protocol affect euploidy and pregnancy rates in preimplatation genetic screening (PGS) cycles with single embryo transfer.

Conditions

Preimplantation Genetic Screening

Keywords

preimplantation genetic screening; gonadotropin dosage; euploidy rates

Outcome Measures

Primary Outcomes (1)

• euploid rates

  the effects of different stimulation protocols on euploid rates

  3 months

Secondary Outcomes (1)

• pregnancy rates

  3 months

Study Arms (2)

100 patients with minimal

In advancing maternal age (AMA) women, minimal stimulation protocol (MSP) with the new combination of human menopausal gonadotrophin (hMG) and clomiphene citrate (CC) were performed for controlled ovarian hyperstimulation is defined for poor ovarian response women.

Genetic: protocol

100 patients with recombinant FSH antagonist protocol

In advancing maternal age (AMA) women, flexible antagonist protocol with recombinant FSH were performed for controlled ovarian hyperstimulation is defined for poor ovarian response women.

Genetic: protocol

Interventions

protocol GENETIC

ovarian stimulation protocols on euploid rates were compared.

100 patients with minimal; 100 patients with recombinant FSH antagonist protocol

Eligibility Criteria

• Age: 38 Years - 45 Years
• Gender Eligibility Details: more than 38 years old
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)
• Sampling Method: Probability Sample

Study Population

200 advanced maternal aged women

Sponsors & Collaborators

• Gokalp Oner: lead

Study Sites (2)

Gokalp Oner

Kayseri, Gevher Nesibe, 38039, Turkey (Türkiye)

NOT YET RECRUITING

Gokalp Oner

Kayseri, Gevher Nesibe, 38039, Turkey (Türkiye)

RECRUITING

Biospecimen

Retention: SAMPLES WITH DNA

embryo

MeSH Terms

Interventions

Clinical Protocols

Intervention Hierarchy (Ancestors)

Therapeutics; Epidemiologic Study Characteristics; Health Care Evaluation Mechanisms; Quality of Health Care; Health Care Quality, Access, and Evaluation

Study Design

• Study Type: observational
• Observational Model: OTHER
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR INVESTIGATOR
• PI Title: Adem Yavuz

Study Record Dates

• First Submitted: January 31, 2022
• First Posted: February 2, 2022
• Study Start: May 15, 2021
• Primary Completion: January 23, 2022
• Study Completion: January 25, 2022
• Last Updated: February 2, 2022

Record last verified: 2022-01

Data Sharing

• IPD Sharing: Will not share

Locations

TU (2)