Total Genotype Score, Growth, Maturation and Loading Exposure as Risk Factors for Injury in Elite Male Youth Football
1 other identifier
observational
95
1 country
2
Brief Summary
A total genotype risk score was generated based on the findings of previous research for non-contact injury, non-contact muscle injury, tendon injury, ligament injury, fracture injury and apophysitis injury. This score was then compared with the incidence of injury between those with high, medium and low risk scores for each injury. The influence of different rates of growth, stages of physical maturation and loading exposure were then also included in the risk model to see if any interaction effects could be observed between genetic risk score and susceptibility to injury in different categories of growth, maturation and loading exposure.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P50-P75 for all trials
Started Dec 2019
2 active sites
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
Study Start
First participant enrolled
December 1, 2019
CompletedPrimary Completion
Last participant's last visit for primary outcome
July 31, 2021
CompletedStudy Completion
Last participant's last visit for all outcomes
July 31, 2021
CompletedFirst Submitted
Initial submission to the registry
January 21, 2022
CompletedFirst Posted
Study publicly available on registry
February 2, 2022
CompletedFebruary 2, 2022
January 1, 2022
1.7 years
January 21, 2022
January 21, 2022
Conditions
Outcome Measures
Primary Outcomes (6)
Fracture Injury Risk
Did the risk of fracture differ between total genotype risk score categories? was this affected by maturation?
8 Years
Non-Contact Injury Risk
Did the risk of non-contact injury differ between total genotype risk score categories? was this affected by maturation, and loading?
8 Years
Non-Contact Muscle Injury Risk
Did the risk of non-contact muscle injury differ between total genotype risk score categories? was this affected by maturation, and loading?
8 Years
Tendon Injury Risk
Did the risk of tendon injury differ between total genotype risk score categories? was this affected by maturation, and loading?
8 Years
Ligament Injury Risk
Did the risk of ligament injury differ between total genotype risk score categories? was this affected by maturation?
8 Years
Apophysitis Injury Risk
Did the risk of ligament injury differ between total genotype risk score categories? was this affected by maturation?
8 Years
Study Arms (1)
Elite male youth footballers
Elite male youth footballers at an English championship / premier league football club
Interventions
A total genotype risk score has been generated based on the results of previously observed genetic association studies
Eligibility Criteria
Elite male football players aged 12-40
You may qualify if:
- Elite male football players
You may not qualify if:
- Female
- non-elite
Contact the study team to confirm eligibility.
Sponsors & Collaborators
- St Mary's University Collegelead
- Fulham Football Clubcollaborator
Study Sites (2)
Fulham Football Club
London, New Malden, KT3 6PT, United Kingdom
St Mary's University, Twickenham
London, Twickenham, TW1 4SX, United Kingdom
MeSH Terms
Conditions
Condition Hierarchy (Ancestors)
Study Design
- Study Type
- observational
- Observational Model
- CASE CONTROL
- Time Perspective
- RETROSPECTIVE
- Sponsor Type
- OTHER
- Responsible Party
- SPONSOR
Study Record Dates
First Submitted
January 21, 2022
First Posted
February 2, 2022
Study Start
December 1, 2019
Primary Completion
July 31, 2021
Study Completion
July 31, 2021
Last Updated
February 2, 2022
Record last verified: 2022-01