NCT05216211

Brief Summary

Caudal epidural block has been a widely used regional anesthesia method, especially in pediatric surgery, to provide intraoperative and postoperative analgesia. Studies on non-invasive methods used for intracranial pressure measurement have shown that optic nerve sheath diameter is related to intracranial pressure. Optic nerve sheath diameter measurement has high diagnostic accuracy for detecting increased intracranial pressure in children. The aim of the study is to investigate the effect of the caudal block on optic nerve sheath diameter in pediatric patients.

Trial Health

87
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
60

participants targeted

Target at P25-P50 for not_applicable postoperative-pain

Timeline
Completed

Started Dec 2021

Geographic Reach
1 country

1 active site

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

First Submitted

Initial submission to the registry

December 9, 2021

Completed
Same day until next milestone

Study Start

First participant enrolled

December 9, 2021

Completed
2 months until next milestone

First Posted

Study publicly available on registry

January 31, 2022

Completed
7 months until next milestone

Primary Completion

Last participant's last visit for primary outcome

September 1, 2022

Completed
2 months until next milestone

Study Completion

Last participant's last visit for all outcomes

October 30, 2022

Completed
Last Updated

December 23, 2022

Status Verified

December 1, 2022

Enrollment Period

9 months

First QC Date

December 9, 2021

Last Update Submit

December 22, 2022

Conditions

Outcome Measures

Primary Outcomes (4)

  • Optic Nerve Diameter

    Consecutive Optic Nerve Sheath Diameter Measurement from Both Eyes

    First minute

  • Optic Nerve Diameter

    Consecutive Optic Nerve Sheath Diameter Measurement from Both Eyes

    5th minutes

  • Optic Nerve Diameter

    Consecutive Optic Nerve Sheath Diameter Measurement from Both Eyes

    15th minutes

  • Optic Nerve Diameter

    Consecutive Optic Nerve Sheath Diameter Measurement from Both Eyes

    30th minutes

Study Arms (2)

Group Caudal

ACTIVE COMPARATOR

Caudal block with 1 ml / kg, % 0.25 bupivacaine

Drug: Bupivacaine Hydrochloride

Group Control

NO INTERVENTION

No intervention

Interventions

1 ml / kg, % 0.25 bupivacaine

Group Caudal

Eligibility Criteria

Age1 Year - 7 Years
Sexall
Healthy VolunteersNo
Age GroupsChild (0-17)

You may qualify if:

  • circumcision,
  • inguinal hernia,
  • undescended testis,
  • hydrocele operation

You may not qualify if:

  • neurological or spinal anomaly,
  • coagulopathy
  • allergy to local anesthetics,
  • local infection in the area to be intervention,
  • with increased intracranial pressure
  • children with any ophthalmic pathology

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

Ataturk University School of Medicine

Erzurum, Yakutiye, 25100, Turkey (Türkiye)

Location

MeSH Terms

Conditions

Pain, PostoperativeIntracranial Hypertension

Interventions

Bupivacaine

Condition Hierarchy (Ancestors)

Postoperative ComplicationsPathologic ProcessesPathological Conditions, Signs and SymptomsPainNeurologic ManifestationsSigns and SymptomsBrain DiseasesCentral Nervous System DiseasesNervous System Diseases

Intervention Hierarchy (Ancestors)

AnilidesAmidesOrganic ChemicalsAniline CompoundsAmines

Study Design

Study Type
interventional
Phase
not applicable
Allocation
RANDOMIZED
Masking
SINGLE
Who Masked
OUTCOMES ASSESSOR
Purpose
DIAGNOSTIC
Intervention Model
PARALLEL
Sponsor Type
OTHER
Responsible Party
PRINCIPAL INVESTIGATOR
PI Title
Principal Investigator

Study Record Dates

First Submitted

December 9, 2021

First Posted

January 31, 2022

Study Start

December 9, 2021

Primary Completion

September 1, 2022

Study Completion

October 30, 2022

Last Updated

December 23, 2022

Record last verified: 2022-12

Locations