Effect and Mechanism of Dopamine on Ulcerative Colitis

NCT05214404 | Completed

• 1 other identifier: Dopamine-UC
• Study Type: observational
• Target: 60
• Locations: 1 country
• Sites: 1

Brief Summary

Increased evidence suggests that dopamine acts as an important regulator of immune function. A substantial amount of dopamine exists in the gastrointestinal tract, especially in colonic lumen. Decreased dopamine level has been reported in the colonic mucosa of ulcerative colitis patients. Therefore, the investigators suppose that colonic dopamine could involve in the ulcerative colitis and play an important role. This study aims to explore the role of dopamine in ulcerative colitis and underlying mechanism, which will provide a rationale for diagnosis and treatment of the ulcerative colitis.

Conditions

Dopamine Dysregulation Syndrome; Ulcerative Colitis

Keywords

Dopamine; Ulcerative Colitis

Outcome Measures

Primary Outcomes (2)

• Comparison of the levels of inflammatory factors in colonic mucosa

  The levels of inflammatory factors in colonic mucosa of ulcerative colitis group and non-ulcerative colitis control group were detected by Elisa to evaluate the degree of inflammation.

  1 day

• Comparison of dopamine content in colonic mucosa

  HPLC-ECD was used to detect and compare the content of dopamine in colonic mucosa between ulcerative colitis group and non-ulcerative colitis group.

  1 day

Study Arms (2)

Ulcerative colitis group

Patients with ulcerative colitis as observation group

Other: Patients diagnosed with ulcerative colitis

Non-ulcerative colitis group

Non-ulcerative colitis as control group

Interventions

Patients diagnosed with ulcerative colitis OTHER

Patients with ulcerative colitis diagnosed by endoscopy and histopathology

Ulcerative colitis group

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

Patients with oulcerative colitis diagnosed by endoscopy and histopathology

You may qualify if:

• Patients with or without ulcerative colitis diagnosed by endoscopy and histopathology
• Negative bacterial culture in stool
• Written informed consent

You may not qualify if:

• Patients with cardiovascular and cerebrovascular diseases, or patients with severe impairment of liver, kidney and hematopoietic system
• Mental patients
• Hemorrhagic diseases
• Platelet count \< 50 × 10 \^ 9 / L
• Allergic constitution
• unable to tolerate or cooperate with endoscopy
• Patients with serious complications, such as intestinal obstruction, intestinal perforation, toxic colonic dilatation, colorectal cancer, etc.
• Pregnant or lactating women

Sponsors & Collaborators

• Affiliated Hospital to Academy of Military Medical Sciences: lead

Study Sites (1)

The Fifth Medical Center of Chinese PLA General Hosptial

Beijing, Beijing Municipality, 100039, China

Location

Biospecimen

Retention: SAMPLES WITH DNA

Endoscopic biopsy specimens of colorectal mucosa

MeSH Terms

Conditions

Colitis, Ulcerative

Condition Hierarchy (Ancestors)

Colitis; Gastroenteritis; Gastrointestinal Diseases; Digestive System Diseases; Inflammatory Bowel Diseases; Colonic Diseases; Intestinal Diseases

Study Officials

• Yan Liu, MD

  Beijing 302 Hospital

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: CASE CONTROL
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: January 5, 2022
• First Posted: January 28, 2022
• Study Start: February 16, 2022
• Primary Completion: August 30, 2022
• Study Completion: September 20, 2022
• Last Updated: September 26, 2022

Record last verified: 2022-09

Data Sharing

• IPD Sharing: Will not share

Locations

CN (1)