Hashtag HPV: HPV Vaccine Twitter Education Program

NCT05204030 | Unknown

• 2 other identifiers: 21083516677R01CA229324-04
• Study Type: interventional
• Target: 600
• Locations: 1 country
• Sites: 1

Brief Summary

Parents use social media as an important parenting tool and source for health information. Using social media data to examine public opinion has had an early impact in public health and in cancer control and prevention efforts, including about the human papillomavirus (HPV) vaccine. A next step in this area of research is to develop and share messages on social media with parents to help inform and educate them about the HPV vaccine - ultimately assisting them with their decision to vaccinate their child. This study will evaluate the efficacy of social media messages through Twitter, using a randomized controlled trial to determine what types of messages resonate with parents. The investigators will examine differences between two types of messages - narrative messages (i.e., stories) and non-narrative messages (i.e., numbers and facts).

Conditions

Human Papilloma Virus; Vaccine-Preventable Diseases

Keywords

Human Papilloma Virus; Human Papilloma Virus Vaccine; Human Papilloma Virus Vaccination; Intervention; Social media; Twitter; Parents; Child health; Cancer prevention; Vaccine acceptance; Narrative engagement; Patient self-report; Intention to vaccinate; community engagement; Public Health; Vaccination

Outcome Measures

Primary Outcomes (2)

• Change in caregiver self-reported HPV vaccination status of child questionnaire

  dependent variable; measure collects date of vaccination and number of vaccine doses to date

  Change in caregiver self-reported HPV vaccination of child at 1-month follow-up from baseline

• Change in caregiver self-reported HPV vaccination status of child questionnaire

  dependent variable; measure collects date of vaccination and number of vaccine doses to date

  Change in caregiver self-reported HPV vaccination of child at 1-year follow-up from 1-month follow-up

Secondary Outcomes (5)

• Caregiver self-reported empathy subscale adapted from Busselle & Bilandzic (2009) and Murphy, Frank, Chatterjee, Baezconde-Garbanati (2013).

  only at 1-month post intervention

• Caregiver self-reported transportation subscale adapted from Murphy, Frank, Chatterjee, Baezconde-Garbanati (2013). Narrative versus Non-narrative: The Role of Identification, Transportation and Emotion in Reducing Health Disparities.

  only at 1-month post intervention

• Caregiver self-reported identification subscale adapted from Murphy, Frank, Chatterjee, Baezconde-Garbanati (2013). Narrative versus Non-narrative: The Role of Identification, Transportation and Emotion in Reducing Health Disparities.

  only at 1-month post intervention

• Change in caregiver self-reported intention to vaccinate their child questionnaire

  Change in caregiver self-reported intention to vaccinate their child at 1-month follow-up from baseline

• Change in caregiver self-reported intention to vaccinate their child questionnaire

  Change in caregiver self-reported intention to vaccinate their child at 1-year follow-up from 1-month follow-up

Study Arms (2)

Narrative

EXPERIMENTAL

The intervention condition will present narrative-focused messages about HPV and the HPV vaccine that includes important parent focused exemplar language and cultural norms on Twitter told through stories and characters (i.e., pseudo-parents).

Other: HPV Twitter Education Program - Narrative

Non-Narrative

ACTIVE COMPARATOR

The non-narrative condition will present scientific-focused messages about HPV and the HPV vaccine that includes important information relayed with numbers and facts.

Other: HPV Twitter Education Program - Non-Narrative

Interventions

HPV Twitter Education Program - Narrative OTHER

This study will evaluate the efficacy of social media messages through Twitter, using a randomized controlled trial to determine what types of messages resonate with parents. The investigators will examine narrative messages (i.e., stories). The central hypothesis is that parents who read narrative-focused messages will be more likely to report narrative engagement, intention to vaccinate their child, and self-reported vaccination compared to parents who read non-narrative messages.

Narrative

HPV Twitter Education Program - Non-Narrative OTHER

This study will evaluate the efficacy of social media messages through Twitter, using a randomized controlled trial to determine what types of messages resonate with parents. The investigators will examine non-narrative messages (i.e., scientific information - numbers and facts). The central hypothesis is that parents who read narrative-focused messages will be more likely to report narrative engagement, intention to vaccinate their child, and self-reported vaccination compared to parents who read non-narrative messages.

Non-Narrative

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Adults 18 years of age and older;
• Utilizes Twitter, a social media platform;
• Has a child aged 9-14;
• Child has not started the 2-dose HPV vaccination series;
• Has no child who has completed any dose HPV vaccination series;
• Has a well-care visit scheduled for their child before December, 2022.

You may not qualify if:

• Any adult who does not have a child 9-14 years of age;
• Any adult who does not indicate some level of participation in Twitter;
• Any adults who indicates a high level of anti-vaccine sentiment (assessed by vaccine hesitancy questions asked in the screener).

Sponsors & Collaborators

• University of Arkansas, Fayetteville: lead
• Thomas Jefferson University: collaborator
• University at Albany: collaborator
• National Cancer Institute (NCI): collaborator
• University of California, Los Angeles: collaborator

Study Sites (1)

University of Arkansas

Fayetteville, Arkansas, 72701, United States

Location

Related Publications (3)

• Massey PM, Kearney MD, Hauer MK, Selvan P, Koku E, Leader AE. Dimensions of Misinformation About the HPV Vaccine on Instagram: Content and Network Analysis of Social Media Characteristics. J Med Internet Res. 2020 Dec 3;22(12):e21451. doi: 10.2196/21451.

  PMID: 33270038 BACKGROUND

• Massey PM, Togo E, Chiang SC, Klassen AC, Rose M, Manganello JA, Leader AE. Identifying HPV vaccine narrative communication needs among parents on social media. Prev Med Rep. 2021 Jul 7;23:101488. doi: 10.1016/j.pmedr.2021.101488. eCollection 2021 Sep.

  PMID: 34295614 BACKGROUND

• Massey PM, Chiang SC, Rose M, Murray RM, Rockett M, Togo E, Klassen AC, Manganello JA, Leader AE. Development of Personas to Communicate Narrative-Based Information About the HPV Vaccine on Twitter. Front Digit Health. 2021 Aug 4;3:682639. doi: 10.3389/fdgth.2021.682639. eCollection 2021.

  PMID: 34713151 BACKGROUND

MeSH Terms

Conditions

Vaccine-Preventable Diseases

Condition Hierarchy (Ancestors)

Infections

Study Officials

• Philip M Massey, PhD, MPH

  University of California, Los Angeles

  STUDY DIRECTOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: SINGLE
• Who Masked: PARTICIPANT
• Purpose: PREVENTION
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Model Details: This 4-year study will evaluate the efficacy of a Twitter-based pilot intervention through a randomized controlled trial that will enroll a total of 600 parents/caregivers of children ages 9-14, whose child(ren) has not started the vaccine series. The intervention will consist of 2 arms and 12 monthly cohorts. After enrollment in the project, 300 participants will be randomized into the intervention arm and 300 participants will be enrolled into the control arm. Participants will be presented the intervention one month before their child's next wellcare visit.

Study Record Dates

• First Submitted: December 9, 2021
• First Posted: January 24, 2022
• Study Start: December 13, 2021
• Primary Completion: August 30, 2023
• Study Completion: August 30, 2023
• Last Updated: January 30, 2023

Record last verified: 2023-01

Data Sharing

• IPD Sharing: Will not share

Locations

US (1)