Neural Correlates of Compulsivity

NCT05195476 | Completed

• 1 other identifier: 7867
• Study Type: observational
• Target: 41
• Locations: 1 country
• Sites: 1

Brief Summary

This study aims to collect data from individuals with obsessive-compulsive disorder (OCD) and healthy controls in order to clarify how learning strategies are employed differently by individuals with compulsive psychopathology and healthy individuals. Behavioral and electroencephalogram (EEG) data will be collected during one experimental reinforcement learning tasks from participants diagnosed with OCD (n = 30) and healthy controls (n = 30). Computational modeling, an advanced data analytic approach that can directly link neural measures with behavior, will be used to quantify learning processes. These parameters then will be related to measures of neural events obtained using EEG, a neuroimaging method that has high temporal resolution, to test for evidence of neurocognitive alterations.

Conditions

Obsessive-Compulsive Disorder

Keywords

Compulsivity; Obsessive-Compulsive Disorder; Exposure and Response Prevention; Electroencephalogram

Outcome Measures

Primary Outcomes (1)

• Neural Activity

  EEG will be recorded while participants complete computerized reinforcement learning tasks at one study visit

  One-time study visit

Study Arms (2)

Individuals diagnosed with OCD

Individuals diagnosed with OCD

Healthy controls

Individuals who have not been diagnosed with any psychiatric disorders

Eligibility Criteria

• Age: 18 Years - 50 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)
• Sampling Method: Non-Probability Sample

Study Population

Individuals diagnosed with OCD and healthy controls

You may qualify if:

• Between 18-50 years of age
• English-speaking
• Capacity to provide informed consent
• Primary diagnosis of OCD with at least moderate severity

You may not qualify if:

• Current or lifetime history of psychiatric disorders other than OCD that may increase the risk of participation
• History of any significant medical condition that may increase the risk of participation
• Alcohol or substance use disorder in the past year
• Exposure and response prevention for OCD within the last six weeks
• Currently taking psychotropic medication

Sponsors & Collaborators

• Columbia University: lead
• International OCD Foundation: collaborator

Study Sites (1)

New York State Psychiatric Institute

New York, New York, 10032, United States

Location

MeSH Terms

Conditions

Obsessive-Compulsive Disorder

Condition Hierarchy (Ancestors)

Anxiety Disorders; Mental Disorders

Study Officials

• Amy Rapp, PhD

  Columbia University

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: CASE CONTROL
• Time Perspective: CROSS SECTIONAL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Assistant Professor of Clinical Medical Psychology (in Psychiatry)

Study Record Dates

• First Submitted: January 4, 2022
• First Posted: January 19, 2022
• Study Start: December 17, 2021
• Primary Completion: February 28, 2024
• Study Completion: February 28, 2024
• Last Updated: May 6, 2024

Record last verified: 2024-05

Locations

US (1)