Study of Camrelizumab in Combination With Apatinib Mesylate Plus Albumin-bound Paclitaxel and Cisplatin as the First Line Treatment of Recurrent or Metastatic, UnresectableHead and Neck Squamous Cell Carcinoma

NCT05189184 | Unknown Phase 2

• 1 other identifier: HNSCC-R/M-01
• Study Type: interventional
• Target: 30
• Locations: 0 countries
• Sites: N/A

Brief Summary

This is a prospective, open-labelled study to evaluate the efficacy and safety of Camrelizumab in Combination With Apatinib mesylate Plus Albumin-bound paclitaxel and cisplatin as the First Line Treatment of Metastatic or Recurrent, UnresectableHead and Neck Squamous Cell Carcinoma. The objective response rate (ORR) will be evaluated as the primary endpoints.

Conditions

Head and Neck Squamous Cell Carcinoma

Outcome Measures

Primary Outcomes (1)

• Objective Response Rate (CR+PR)

  Objective response rate (ORR) according to RECIST1.1

  Time Frame: Up to 24 months

Secondary Outcomes (2)

• Overall survival (OS)

  Up to 24 months

• Progression free survival (PFS)

  Up to 24 months

Study Arms (1)

Study group

EXPERIMENTAL

Inductive therapy with Camrelizumab and Apatinib Plus Albumin-bound paclitaxel and cisplatin

Drug: Camrelizumab+Apatinib mesylate+Albumin-bound paclitaxel+cisplatin

Interventions

Camrelizumab+Apatinib mesylate+Albumin-bound paclitaxel+cisplatin DRUG

Camrelizumab in Combination With Apatinib mesylate Plus Albumin-bound paclitaxel and cisplatin as the First Line Treatment of Recurrent or Metastatic , UnresectableHead and Neck Squamous Cell Carcinoma (HNSCC)

Study group

Eligibility Criteria

• Age: 18 Years - 75 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• 、Has fully understood and voluntarily signed an written Informed Consent and agreed to follow the research plan treatment and visiting plan; 2、Aged \>=18 years; 3、Histologically confirmed recurrent or metastatic HNSCC of the oral cavity, oropharynx, hypopharynx, and/or larynx that is considered incurable by local therapies； 4、Eastern Cooperative Oncology Group (ECOG) performance status 0-1; 5、Expected survival period ≥ 3 months； 6、Tumor tissue with PD-L1 detection (paraffin specimens or fresh tumor tissue within 2 years) can be provided or PD-L1 test report of tumor tissue samples issued by a state-approved qualification unit； 7、At least one measurable lesion, according to RECIST 1.1; 8、Toxicity of the subject has been restored to the ≤1 level defined by NCI-CTCAE V5.0 (except hair loss)； 9、Patients must be able to swallow oral drugs and do not have significant affected gastrointestinal abnormalities, such as absorption adverse syndrome or most of the gastrointestinal tract; 10、The main function is normal, the test results at the time of screening must meet the following requirements:
• Blood routine (no blood transfusion, erythropoietin (EPO), granulocyte-colony-stimulating factor (G-CSF) or granulocyte-macrophage-colony-stimulating factor (GM-CSF) within 14 days prior to screening) :
• A.Hemoglobin (HB) ≥ 90 g / L; B.Absolute neutrophil count (ANC) of \>= 1.5\*10\^9/L； C.platelet count of \>= 100\*10\^9/L；
• Biochemical examination needs to meet the following criteria:
• A.TBIL \< 1.5 ULN (Gilbert syndrome patient, \< 3 ULN); B.ALT and AST \< 3 ULN, if there exists hepatic metastases, ALT and AST \< 5 ULN； C.Cr \<=1.5 ULN or CCr ≥50ml/min;
• Echocardiography：LVEF≥50%；
• INR or PT \<= 1.5 ULN, APTT \<=1.5 ULN； 11、Contraception: Women of childbearing age should agree to use effective contraception during the study and for 6 months after the end of the study; Negative serum or urine pregnancy test within 7 days prior to study enrollment and must be non-lactating; Men who agreed to use contraception during the study period and for six months after the end of the study period.

You may not qualify if:

• Those who are allergic to drug treatment;
• Disease that is suitable for local therapy administered with curative intent；
• Accept system chemotherapy, but does not include a circulation of a multi-mode treatment for chemotherapy for local advanced diseases (this treatment end time must be 6 months from the first test for the first test);
• Patients with local advanced head and neck squamous cell carcinoma have completed multi-mode chemotherapy completed within 6 months of disease progression;
• It has received immunotherapy for anti-PD-1, anti-PD-L1, anti-PD-L2, anti-CD137 or anti-CTLA-4 antibody or targeted to T cell common stimulation or immunoction point pathway;
• There have been any malignant tumors in five years, except for other malignant tumors,cervical in situ cancer, non-melanoma skin cancer or other tumors / cancer that passively treats for at least 5 years without disease;
• Anti-blood vessel treatment was received within 6 months before administration;
• According to NCI CTCAEV5.0, there have been peripheral neuropathy ≥ 2;
• Accompanied by known active central nervous system transfer (CNS) and / or cancer meningitis: Previously received brain transfer subjects can participate in research, premise is the clinical stability for at least 2 weeks, no new or expanded brains Transfer evidence, and 14 days before the drug administration, steroids were stopped 14 days. The stable brain transfer in this definition should be determined before the study of drugs for the first time. The invisible brain transfer subject (ie there is no nervous system symptoms, no corticosteroids, no lesions\> 1.5 cm) can participate, but need to periodically perform brain imaging in the disease site;
• It has not been recovered from any acute impact of past surgery, chemotherapy or radiotherapy, ie, the subject of ≤1 (NCI CTCAEV5.0) (except for external hair loss), if the nutritional state is stable, it is allowed to radiotherapy and / or surgery Produced chronic advanced toxicity (pharyngeal / throat, namely oral dry, speech, swallowing abnormal)；
• Within 4 weeks or 4 weeks before the first administration, the anti-tumor drug treatment (such as chemotherapy, hormone therapy, immunotherapy, antibody treatment, radiotherapy, etc.), except for reducing pain on bones, except for bones;
• It has received major surgery within the 4 weeks of the first administration or is expected to carry out major surgery during this study;
• In the first 2 weeks or 2 weeks of the first administration, immunosuppressive drugs is required, and the following is eliminated:
• intranasal, inhalation, external use steroids or local steroid injection (such as joint internal injection);
• physiological doses of systemic corticosteroids (≤10 mg / connone or equivalent dose);

Sponsors & Collaborators

• The First Affiliated Hospital of Zhengzhou University: lead
• Jiangsu HengRui Medicine Co., Ltd.: collaborator

MeSH Terms

Conditions

Squamous Cell Carcinoma of Head and Neck

Condition Hierarchy (Ancestors)

Carcinoma, Squamous Cell; Carcinoma; Neoplasms, Glandular and Epithelial; Neoplasms by Histologic Type; Neoplasms; Head and Neck Neoplasms; Neoplasms by Site

Study Design

• Study Type: interventional
• Phase: phase 2
• Allocation: NA
• Masking: NONE
• Purpose: TREATMENT
• Intervention Model: SINGLE GROUP
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Chief physician

Study Record Dates

• First Submitted: December 29, 2021
• First Posted: January 12, 2022
• Study Start: March 30, 2022
• Primary Completion: March 30, 2025
• Study Completion: March 30, 2025
• Last Updated: January 12, 2022

Record last verified: 2021-12

Data Sharing

• IPD Sharing: Will not share