NCT05186636

Brief Summary

Implementation of an evidence-based and best practices acute RRT pathway aiming to decrease acute RRT program and healthcare systems costs while improving important patient-reported outcomes.

Trial Health

77
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
4,500

participants targeted

Target at P75+ for all trials

Timeline
5mo left

Started Jan 2023

Typical duration for all trials

Geographic Reach
1 country

15 active sites

Status
recruiting

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Progress89%
Jan 2023Sep 2026

First Submitted

Initial submission to the registry

December 9, 2021

Completed
1 month until next milestone

First Posted

Study publicly available on registry

January 11, 2022

Completed
1 year until next milestone

Study Start

First participant enrolled

January 12, 2023

Completed
3.4 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

May 31, 2026

Expected
4 months until next milestone

Study Completion

Last participant's last visit for all outcomes

September 30, 2026

Last Updated

March 16, 2026

Status Verified

March 1, 2026

Enrollment Period

3.4 years

First QC Date

December 9, 2021

Last Update Submit

March 12, 2026

Conditions

Acute Renal Injury

Keywords

evidence based care pathway,critical care medicinequality improvementacute renal replacement therapy

Outcome Measures

Primary Outcomes (2)

  • Key performance indicators (KPI)

    Changes in acute KPIs

    Throughout intervention period up to 3 years

  • Health system costs

    Acute RRT and healthcare systems costs

    3 years

Secondary Outcomes (4)

  • Length of renal replacement therapy

    3 years

  • ICU and hospital lengths of stay

    3 years

  • ICU and 90 day mortality

    3 years

  • Rates of RRT dependence at 90 days

    3 years

Study Arms (1)

ICU patients receiving renal replacement therapy

All patients in participating ICU's receiving CRRT or IRRT during the study period

Other: KPI reportsOther: Prescriber reports

Interventions

KPI reportsOTHER

Quarterly

Also known as: Monitoring, reporting and regular review of acute RRT KPIs
ICU patients receiving renal replacement therapy
Prescriber reportsOTHER

Individualized prescriber reports for acute RRT initiation patterns along with targeted education to ensure that align with best evidence-based practices

ICU patients receiving renal replacement therapy

Eligibility Criteria

Sexall
Healthy VolunteersNo
Age GroupsChild (0-17), Adult (18-64), Older Adult (65+)
Sampling MethodProbability Sample
Study Population

All patients from 15 adult and 3 pediatric Alberta ICUs who receive acute RRT as part of their usual clinical care during the intervention period

You may qualify if:

  • Patient in one of 15 adult and 3 pediatric intensive care units in Alberta Receive acute RRT as part of their usual clinical care during the intervention period

You may not qualify if:

  • none

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (15)

Peter Lougheed Centre

Calgary, Alberta, T1Y 6J4, Canada

RECRUITING

Foothills Medical Centre

Calgary, Alberta, T2N 2T9, Canada

RECRUITING

Rockyview General Hospital

Calgary, Alberta, T2V 1P9, Canada

RECRUITING

Alberta Children's Hospital

Calgary, Alberta, T3B 6A8, Canada

RECRUITING

South Health Campus

Calgary, Alberta, T3M 1M4, Canada

RECRUITING

Royal Alexandra Hospital

Edmonton, Alberta, T5H 3V9, Canada

RECRUITING

Misericordia Community Hospital

Edmonton, Alberta, T5R 4H5, Canada

RECRUITING

Manzankowski Alberta Heart Institute

Edmonton, Alberta, T6G 2B7, Canada

RECRUITING

Stollery Children's Hospital

Edmonton, Alberta, T6G 2B7, Canada

RECRUITING

University of Alberta Hospital

Edmonton, Alberta, T6G-2B7, Canada

RECRUITING

Grey Nuns Community Hospital

Edmonton, Alberta, T6L 5X8, Canada

RECRUITING

Grande Prairie Regional Hospital

Grande Prairie, Alberta, T8V 4B1, Canada

RECRUITING

Chinook Regional Hospital

Lethbridge, Alberta, T1J 1W5, Canada

RECRUITING

Red Deer Regional Hospital Centre

Red Deer, Alberta, T4N 4E7, Canada

RECRUITING

Sturgeon Community Hospital

St. Albert, Alberta, T8N 6C4, Canada

RECRUITING

Related Publications (1)

  • Opgenorth D, Bagshaw SM, Lau V, Graham MM, Fraser N, Klarenbach S, Morrin L, Norris C, Pannu N, Sinnadurai S, Valaire S, Wang X, Rewa OG. A study protocol for improving the delivery of acute kidney replacement therapy (KRT) to critically ill patients in Alberta - DIALYZING WISELY. BMC Nephrol. 2022 Nov 16;23(1):369. doi: 10.1186/s12882-022-02990-6.

    PMID: 36384465DERIVED

MeSH Terms

Conditions

Acute Kidney Injury

Condition Hierarchy (Ancestors)

Renal InsufficiencyKidney DiseasesUrologic DiseasesFemale Urogenital DiseasesFemale Urogenital Diseases and Pregnancy ComplicationsUrogenital DiseasesMale Urogenital Diseases

Study Officials

  • Oleksa Rewa, MD

    University of Alberta

    PRINCIPAL INVESTIGATOR

Central Study Contacts

Dawn Opgenorth, RN

CONTACT

780 492-4698dawno@ualberta.ca

Oleksa Rewa, MD

CONTACT

rewa@ualberta.ca

Study Design

Study Type
observational
Observational Model
OTHER
Time Perspective
PROSPECTIVE
Sponsor Type
OTHER
Responsible Party
SPONSOR

Study Record Dates

First Submitted

December 9, 2021

First Posted

January 11, 2022

Study Start

January 12, 2023

Primary Completion (Estimated)

May 31, 2026

Study Completion (Estimated)

September 30, 2026

Last Updated

March 16, 2026

Record last verified: 2026-03

Locations

CA(15)