Investigation of the Relationship Between Blood Transfusion Volume and Development of Renal Failure in Pediatric Patients Undergoing Cardiovascular Surgery

NCT06889272 | Completed

• 2 other identifiers: Yusuf CELIKMurat IZGI
• Study Type: observational
• Target: 205
• Locations: 1 country
• Sites: 1

Brief Summary

Blood transfusion strategies in cardiac surgery are a research topic that has been studied more for adults. There is not enough data on this subject for children in studies. Investigators aim to examine the renal damage risk level of blood transfusion volume, which is one of the modifiable risk factors that can cause acute kidney injury in pediatric cases undergoing cardiac surgery. The main question it aims to answer is: What is the effect of blood transfusion volume on the risk of renal damage in pediatric cardiovascular surgery? The names of the patients who were operated on by the Department of Cardiovascular Surgery will be accessed from the system records and their files will be reviewed. The patients' demographic information, anesthesia management and postoperative renal function tests will be scanned.

Conditions

Congenital Cardiac Defect; Acute Renal Injury; Blood Transfusion Complication

Outcome Measures

Primary Outcomes (1)

• postoperative acute renal failure

  From registration to the end of the second postoperative day

Study Arms (2)

patients with acute kidney injury

blood transfusion during surgery

Other: blood transfusion

patients without acute kidney injury

blood transfusion during surgery

Other: blood transfusion

Interventions

blood transfusion OTHER

Red blood cell suspension replacement during surgery

patients with acute kidney injury; patients without acute kidney injury

Eligibility Criteria

• Age: Up to 18 Years
• Sex: all
• Age Groups: Child (0-17), Adult (18-64)
• Sampling Method: Non-Probability Sample

Study Population

Pediatric patients who applied to Hacettepe University Faculty of Medicine (HÜTF) Hospital and underwent cardiac surgery by the Department of Cardiovascular Surgery between January 1, 2013 and December 31, 2023 will be included in the study.

You may qualify if:

• pediatric patients undergoing cardiovascular surgery

You may not qualify if:

• Being over 18 years old Weighting over 30 kg Preoperative acute kidney injury

Sponsors & Collaborators

• Hacettepe University: lead

Study Sites (1)

Hacettepe University Anesthesiology and Reanimation

Ankara, Turkey (Türkiye)

Location

MeSH Terms

Conditions

Heart Defects, Congenital; Acute Kidney Injury; Transfusion Reaction

Interventions

Blood Transfusion

Condition Hierarchy (Ancestors)

Cardiovascular Abnormalities; Cardiovascular Diseases; Heart Diseases; Congenital Abnormalities; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Renal Insufficiency; Kidney Diseases; Urologic Diseases; Female Urogenital Diseases; Female Urogenital Diseases and Pregnancy Complications; Urogenital Diseases; Male Urogenital Diseases; Hematologic Diseases; Hemic and Lymphatic Diseases; Immune System Diseases

Intervention Hierarchy (Ancestors)

Biological Therapy; Therapeutics

Study Officials

• Murat Izgi

  Assistant professor

  STUDY DIRECTOR

Study Design

• Study Type: observational
• Observational Model: CASE CONTROL
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Assistant Professor

Study Record Dates

• First Submitted: February 18, 2025
• First Posted: March 21, 2025
• Study Start: January 31, 2024
• Primary Completion: April 1, 2024
• Study Completion: June 30, 2024
• Last Updated: March 21, 2025

Record last verified: 2025-03

Locations

TU (1)