Ankle Pain and Orientation After High Tibial Osteotomy as a Treatment of Medial Compartment Knee Osteoarthritis

NCT05183750 | Completed

• 1 other identifier: Soh-Med-21-12-18
• Study Type: interventional
• Target: 20
• Locations: 1 country
• Sites: 1

Brief Summary

Changes in demographics and physical activities of the young population have increased the number of patients with medial unicompartmental knee osteoarthritis (OA) requiring surgical intervention. High tibial osteotomy (HTO) have shown good clinical results in restoring lower extremity alignment, reducing pain, and improving knee function in patients with moderate-to-severe knee osteoarthritis and genu varum deformity. The aim of this study is to evaluate the relation between correction of the malalignment of the knee and ankle pain and orientation in patient of medial compartment knee osteoarthritis using high tibial osteotomy by recent reports concerning the indications, functional outcomes and complication.

Conditions

Investigate the Change in the Weight-bearing-line (WBL) Ratio of the Ankle Joint and Ankle Joint Line Orientation After HTO

Outcome Measures

Primary Outcomes (3)

• Ankle pain (visual analogue score)

  The visual analog scale (VAS) is a validated, subjective measure for acute and chronic pain. Scores represents a continuum between no pain 0 and worst pain 10.

  1year post operative follow up

• Coronal alignment of the ankle

  Tibial plafond inclination (TPI) (2) Talar inclination (TI) (3) Talar tilt (TT)and (4) Lateral distal tibial angle (LDTA)

  1year post operative follow up

• coronal plane correction

  hip-knee-ankle (HKA) angle, medial proximal tibial angle (MPTA), and knee-tibial plafond angle (KTPA)

  1year post operative follow up

Study Arms (1)

Adult with isolated medial compartmental knee osteoarthtitis

OTHER

Procedure: High tibial osteotomy

Interventions

High tibial osteotomy PROCEDURE

Opening wedge high tibial osteotomy will be done according to the measurement preoperatively and fixation will be by plate and screws.

Adult with isolated medial compartmental knee osteoarthtitis

Eligibility Criteria

• Age: 18 Years - 55 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64)

You may qualify if:

• Symptomatic medial unicompartment knee arthritis
• Active patients younger than 55 years
• Good range of motion (ROM) .
• Intact lateral compartment

You may not qualify if:

• Combined medial and lateral arthrosis.
• Markedly decreased knee range of motion (arc of motion 10°).
• Ligamentous instability.
• Severe joint destruction (≥Ahlback grade III).
• ≥55 years of age.
• Advanced patellofemoral arthritis.
• Rheumatoid arthritis.
• Structural lower extremity deformities.
• Previous operation at knee joint.

Sponsors & Collaborators

• Sohag University: lead

Study Sites (1)

Sohag univeristy- Faculty of medicine

Sohag, 82511, Egypt

Location

Related Publications (6)

• Kijowski R, Blankenbaker D, Stanton P, Fine J, De Smet A. Arthroscopic validation of radiographic grading scales of osteoarthritis of the tibiofemoral joint. AJR Am J Roentgenol. 2006 Sep;187(3):794-9. doi: 10.2214/AJR.05.1123.

  PMID: 16928947 BACKGROUND

• Lee JH, Jeong BO. Radiologic changes of ankle joint after total knee arthroplasty. Foot Ankle Int. 2012 Dec;33(12):1087-92. doi: 10.3113/FAI.2012.1087.

  PMID: 23199858 BACKGROUND

• Ducat A, Sariali E, Lebel B, Mertl P, Hernigou P, Flecher X, Zayni R, Bonnin M, Jalil R, Amzallag J, Rosset P, Servien E, Gaudot F, Judet T, Catonne Y. Posterior tibial slope changes after opening- and closing-wedge high tibial osteotomy: a comparative prospective multicenter study. Orthop Traumatol Surg Res. 2012 Feb;98(1):68-74. doi: 10.1016/j.otsr.2011.08.013. Epub 2012 Jan 12.

  PMID: 22244250 BACKGROUND

• Gaasbeek R, Welsing R, Barink M, Verdonschot N, van Kampen A. The influence of open and closed high tibial osteotomy on dynamic patellar tracking: a biomechanical study. Knee Surg Sports Traumatol Arthrosc. 2007 Aug;15(8):978-84. doi: 10.1007/s00167-007-0305-0. Epub 2007 May 5.

  PMID: 17483931 BACKGROUND

• JACKSON JP, WAUGH W. Tibial osteotomy for osteoarthritis of the knee. J Bone Joint Surg Br. 1961 Nov;43-B:746-51. doi: 10.1302/0301-620X.43B4.746. No abstract available.

  PMID: 14036496 BACKGROUND

• Lustig S, Scholes CJ, Costa AJ, Coolican MJ, Parker DA. Different changes in slope between the medial and lateral tibial plateau after open-wedge high tibial osteotomy. Knee Surg Sports Traumatol Arthrosc. 2013 Jan;21(1):32-8. doi: 10.1007/s00167-012-2229-6. Epub 2012 Oct 4.

  PMID: 23052121 BACKGROUND

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NA
• Masking: NONE
• Purpose: TREATMENT
• Intervention Model: SINGLE GROUP
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Specialist of Orthopedic and Trauma Surgery

Study Record Dates

• First Submitted: December 17, 2021
• First Posted: January 11, 2022
• Study Start: December 15, 2021
• Primary Completion: September 10, 2025
• Study Completion: September 15, 2025
• Last Updated: September 23, 2025

Record last verified: 2025-09

Locations

EG (1)