Retrospective Analysis of Chest X-ray Severity Scoring System of COVID-19 Pneumonia

NCT05181696 | Recruiting

• 1 other identifier: OsijekUH-RC
• Study Type: observational
• Target: 200
• Locations: 1 country
• Sites: 1

Brief Summary

The research will be retrospective, and will include all patients who were admitted during 2020 and 2021 in the COVID-19 ICU of University Hospital Center Osijek due to pneumonia caused by the Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The association of chest x-ray infiltrate evolution with changes in laboratory inflammatory parameters and respiratory function parameters will be examined.

Conditions

COVID-19 Pneumonia; Sepsis; SARS-CoV-2 Acute Respiratory Disease; Pneumonia; Multiorgan Failure

Keywords

COVID-19; Acute respiratory distress syndrome (ARDS); Sepsis; Multiorgan Failure; Chest X-ray; Inflammation

Outcome Measures

Primary Outcomes (2)

• Chest x-ray severity score

  The influence of the dynamics of radiographic changes quantified by Brixia score on the outcome of COVID-19 patients will be examined

  21 days

• Inflammatory markers

  The influence of serum levels of inflammatory parameters, and clinical and laboratory indicators of organic failure on chest x-ray severity score will be examined

  21 days

Study Arms (1)

COVID-19 pneumonia patients

Patients treated at the University Hospital Osijek Respiratory Center with pneumonia caused by SARS-CoV-2

Diagnostic Test: Chest X-ray

Interventions

Chest X-ray DIAGNOSTIC_TEST

Retrospective analysis of chest x-rays of patients with COVID-19

COVID-19 pneumonia patients

Eligibility Criteria

• Age: 18 Years - 90 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

All patients treated in ICU COVID-19 with a diagnosis of pneumonia will be analyzed retrospectively.

You may qualify if:

• Pneumonia caused by SARS-CoV-2 virus
• Admission to the ICU COVID-19 unit

You may not qualify if:

• \- Patients with lung tumors or history of lung resection

Sponsors & Collaborators

• Osijek University Hospital: lead

Study Sites (1)

University hospital Osijek

Osijek, 31000, Croatia

RECRUITING

Related Publications (5)

• Booth A, Reed AB, Ponzo S, Yassaee A, Aral M, Plans D, Labrique A, Mohan D. Population risk factors for severe disease and mortality in COVID-19: A global systematic review and meta-analysis. PLoS One. 2021 Mar 4;16(3):e0247461. doi: 10.1371/journal.pone.0247461. eCollection 2021.

  PMID: 33661992 BACKGROUND

• Wolff D, Nee S, Hickey NS, Marschollek M. Risk factors for Covid-19 severity and fatality: a structured literature review. Infection. 2021 Feb;49(1):15-28. doi: 10.1007/s15010-020-01509-1. Epub 2020 Aug 28.

  PMID: 32860214 BACKGROUND

• Mahat RK, Panda S, Rathore V, Swain S, Yadav L, Sah SP. The dynamics of inflammatory markers in coronavirus disease-2019 (COVID-19) patients: A systematic review and meta-analysis. Clin Epidemiol Glob Health. 2021 Jul-Sep;11:100727. doi: 10.1016/j.cegh.2021.100727. Epub 2021 Mar 20.

  PMID: 33778183 BACKGROUND

• Borghesi A, Maroldi R. COVID-19 outbreak in Italy: experimental chest X-ray scoring system for quantifying and monitoring disease progression. Radiol Med. 2020 May;125(5):509-513. doi: 10.1007/s11547-020-01200-3. Epub 2020 May 1.

  PMID: 32358689 BACKGROUND

• Borghesi A, Zigliani A, Masciullo R, Golemi S, Maculotti P, Farina D, Maroldi R. Radiographic severity index in COVID-19 pneumonia: relationship to age and sex in 783 Italian patients. Radiol Med. 2020 May;125(5):461-464. doi: 10.1007/s11547-020-01202-1. Epub 2020 May 1.

  PMID: 32358691 BACKGROUND

MeSH Terms

Conditions

Sepsis; Pneumonia; Multiple Organ Failure; COVID-19; Respiratory Distress Syndrome; Inflammation

Interventions

Diagnostic Imaging

Condition Hierarchy (Ancestors)

Infections; Systemic Inflammatory Response Syndrome; Pathologic Processes; Pathological Conditions, Signs and Symptoms; Respiratory Tract Infections; Lung Diseases; Respiratory Tract Diseases; Shock; Pneumonia, Viral; Virus Diseases; Coronavirus Infections; Coronaviridae Infections; Nidovirales Infections; RNA Virus Infections; Respiration Disorders

Intervention Hierarchy (Ancestors)

Diagnostic Techniques and Procedures; Diagnosis

Study Officials

• Nenad Nešković, PhD

  University Hospital Osijek

  PRINCIPAL INVESTIGATOR

Central Study Contacts

Nenad Nešković, PhD

CONTACT

+395996787250; nneskov@gmail.com

Ivana Haršanji Drenjančević, PhD

CONTACT

+385915108941; ihdrenjan@gmail.com

Study Design

• Study Type: observational
• Observational Model: CASE CONTROL
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: January 4, 2022
• First Posted: January 6, 2022
• Study Start: January 1, 2020
• Primary Completion: May 1, 2025
• Study Completion: May 1, 2025
• Last Updated: September 19, 2024

Record last verified: 2024-07

Locations

CR (1)