Modified Shock Index

NCT07479563 | Not Yet Recruiting DMC

• 1 other identifier: Soh-Med-26-2-14MS
• Study Type: observational
• Target: 70
• Locations: 0 countries
• Sites: N/A

Brief Summary

The Emergence of Modified Shock Index (MSI) To further enhance the assessment of hemodynamic stability, the modified shock index (MSI) was developed. The MSI is defined as the ratio of heart rate to mean arterial pressure (MAP) This index takes into account the effect of diastolic blood pressure by replacing SBP with MAP in the calculation . The modified shock index has proven to be a superior predictor of mortality compared to traditional SI . It outperforms heart rate, systolic blood pressure, diastolic blood pressure, and SI as individual predictors

Conditions

Sepsis

Keywords

Modified shock index

Outcome Measures

Primary Outcomes (1)

• Modified Shock Index in patients with sepsis presenting to the Emergency Department

  To assess the Modified Shock Index (MSI), calculated as the ratio of heart rate (beats per minute) to mean arterial pressure (mmHg), in adult patients presenting with sepsis to the Emergency Department, and evaluate its prognostic value.

  At baseline (upon presentation to the Emergency Department)

Secondary Outcomes (1)

• 1. Association between Modified Shock Index and ICU admission 2. Association between Modified Shock Index and vasopressor requirement 3-Association between MSI and need for mechanical ventilation 4_Association between MSI and length of hospital stay

  1_Within 24 hours of Emergency Department presentation. 2_During the first 24 hours of hospital admission. 3_During the first 24 hours of hospital admission. 4_From hospital admission until hospital discharge.

Study Arms (1)

assess the ability of Modified Shock Index (MSI) at Emergency Department presentation to predict in-

evaluate the association between MSI and: * Intensive care unit (ICU) admission * Need for vasopressor support * Need for mechanical ventilation * Length of hospital stay

Other: Chest x-ray; Diagnostic Test: CBC

Interventions

Chest x-ray OTHER

Smear from sputum or urine to identify the site of infection

Also known as: Sputum culture, Urine culture

assess the ability of Modified Shock Index (MSI) at Emergency Department presentation to predict in-

CBC DIAGNOSTIC_TEST

Identify the infection by sepsis markers

Also known as: CRP, ESR, Kidney function tests

assess the ability of Modified Shock Index (MSI) at Emergency Department presentation to predict in-

Eligibility Criteria

• Age: 18 Years - 65 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

People above 18 years old presenting with sepsis

You may qualify if:

• Age ≥ 18 years Presentation to the ED with sepsis(Suspected or confirmed infection plus Evidence of organ dysfunction) (SOFA score ≥ 2 from baseline)

You may not qualify if:

• Pregnancy
• \* poly traumatized patients
• \* Cardiac arrest on arrival
• \* Patients with significant cardiac arrhythmia including atrial fibrillation with rapid ventricular response, or pacemaker-dependent rhythms
• \* Patients transferred from another hospital after initial resuscitation

Sponsors & Collaborators

• Sohag University: lead

MeSH Terms

Conditions

Sepsis

Interventions

X-Rays; Kidney Function Tests

Condition Hierarchy (Ancestors)

Infections; Systemic Inflammatory Response Syndrome; Inflammation; Pathologic Processes; Pathological Conditions, Signs and Symptoms

Intervention Hierarchy (Ancestors)

Electromagnetic Radiation; Electromagnetic Phenomena; Magnetic Phenomena; Physical Phenomena; Radiation; Radiation, Ionizing; Diagnostic Techniques, Urological; Diagnostic Techniques and Procedures; Diagnosis

Study Officials

• Heba M Sadek, Master

  Sohag University

  PRINCIPAL INVESTIGATOR

Central Study Contacts

Heba M Sadek, Master

CONTACT

01022943631; heba05988@gmail.com

Nayel A Zaki, Professor

CONTACT

010 17606718; heba05988@gmail.com

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Target Duration: 1 Day
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Resident

Study Record Dates

• First Submitted: February 27, 2026
• First Posted: March 18, 2026
• Study Start: March 1, 2026
• Primary Completion (Estimated): March 1, 2027
• Study Completion (Estimated): April 1, 2027
• Last Updated: March 18, 2026

Record last verified: 2026-03

Data Sharing

• IPD Sharing: Will not share