Non-invasive Brain Mapping of Movement Facilitation in Parkinson's Disease

NCT05179187 | Active Not Recruiting

• 2 other identifiers: 19-0021351K23NS119568
• Study Type: interventional
• Target: 90
• Locations: 1 country
• Sites: 1

Brief Summary

Several strategies or contexts help patients with Parkinson's disease to move more quickly or normally, however the brain mechanisms underlying these phenomena are poorly understood. The proposed studies use complimentary brain mapping techniques to understand the brain mechanisms supporting improved movements elicited by external cues. The central hypothesis is that distinct networks are involved in movement improvement depending on characteristics of the facilitating stimulus. Participants will perform movement tasks during recording of brain activity with EEG and MRI. The identified biomarkers may provide targets for future neuromodulation therapies to improve symptoms that are refractory to current treatments, such as freezing of gait.

Conditions

Parkinson Disease

Keywords

movement; external cueing; brain mapping

Outcome Measures

Primary Outcomes (3)

• EEG recordings

  EEG power in the beta band

  baseline

• BOLD fMRI: functional brain connectivity

  Blood oxygen level dependent (BOLD) resting state network activity as a function of behavioral benefits from external cues

  up to 4 weeks

• Diffusion tractography imaging (MRI): structural brain connectivity

  Diffusion tensor fractional anisotropy as a function of behavioral benefits from external cues

  up to 4 weeks

Study Arms (2)

Parkinson disease patients

EXPERIMENTAL

Participants diagnosed with Parkinson's disease

Behavioral: Movement task

Healthy adults

ACTIVE COMPARATOR

Healthy adult age-matched controls

Behavioral: Movement task

Interventions

Movement task BEHAVIORAL

Computer task with experimental conditions manipulating sensory and motivation cues for movement.

Also known as: Computer task

Healthy adults; Parkinson disease patients

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Diagnosis of Parkinson's disease based on presence of at least 2 cardinal features (tremor, rigidity or bradykinesia) OR healthy adult with no neurologic disease
• Age \> 18 years old

You may not qualify if:

• Dementia as indicated by score on Montreal Cognitive Assessment \< 19
• Active hallucinations or psychosis
• Contraindications to MRI (metal implant, claustrophobia)

Sponsors & Collaborators

• University of California, Los Angeles: lead
• National Institute of Neurological Disorders and Stroke (NINDS): collaborator

Study Sites (1)

University of California Los Angeles

Los Angeles, California, 90095, United States

Location

MeSH Terms

Conditions

Parkinson Disease

Condition Hierarchy (Ancestors)

Parkinsonian Disorders; Basal Ganglia Diseases; Brain Diseases; Central Nervous System Diseases; Nervous System Diseases; Movement Disorders; Synucleinopathies; Neurodegenerative Diseases

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NON RANDOMIZED
• Masking: NONE
• Purpose: BASIC SCIENCE
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Assistant Professor in Residence

Model Details: All participants undergo the same behavioral interventions in which upper extremity movements are made in response to different sensory stimuli.

Study Record Dates

• First Submitted: December 16, 2021
• First Posted: January 5, 2022
• Study Start: July 6, 2022
• Primary Completion (Estimated): September 1, 2026
• Study Completion (Estimated): September 1, 2026
• Last Updated: January 7, 2026

Record last verified: 2026-01

Data Sharing

• IPD Sharing: Will not share

Locations

US (1)