LGG Supplementation in Patients With AUD and ALD

You may not qualify if:

• Current (last 12 months) DSM V diagnosis of dependence on any psychoactive substance other than alcohol or nicotine,
• Positive urine drug screen at baseline for any illegal substance other than marijuana,
• History of hospitalization for alcohol intoxication delirium, alcohol withdrawal delirium or seizure,
• Participation in any research study for alcoholism treatment within 3 months prior to signing the informed consent,
• Pharmacological treatment with naltrexone, acamprosate, topiramate, or disulfiram within 1 month prior to randomization,
• Lifetime diagnosis based on DSM-V criteria of schizophrenia, bipolar disorder, or other psychosis, eating disorders; current or past year diagnosis of major depression
• In the investigators' opinion, moderate to severe risk of suicide (e.g., active plan, or recent attempt in last 6 months),
• Current use of psychotropic medications that cannot be discontinued,
• Clinically significant medical abnormalities (apart from moderate ALD, MELD≤19),
• Clinical Institute Withdrawal Assessment for Alcohol revised (CIWA-Ar) \>10, at screening for more than 3 days,
• Serious medical diseases, such as cancer, liver cirrhosis, pancreatitis, severe alcohol associated hepatitis, heart chronic failure, chronic kidney failure, chronic intestinal diseases (e.g., Crohn's disease), chronic neurological disorders (e.g., tardive dyskinesia, epilepsy, Parkinson's disease)
• History of clinically significant hypotension (e.g., history of lipotimia and/or syncopal episodes)
• History of adverse reactions to needle puncture,
• Obesity (BMI ≥ 33.0 kg/m2),
• Pregnancy; incarceration; inability to provide consent
• +2 more criteria